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List of works by Aleksi Tornio

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

scientific article

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

scientific article published on 22 September 2009

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel

scientific article published on 20 August 2018

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

scientific article

Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation.

scientific article

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .

scientific article

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin

article

Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel

scientific article published on 09 August 2018

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

scientific article

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

scientific article published on 10 January 2019

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

scientific article published on 24 November 2017

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics

scientific article published on 23 September 2017

Cytochrome P450 in Pharmacogenetics: An Update

scientific article published on 01 January 2018

Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications ⬇️

scientific article published on 02 April 2012

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

scientific article

Effect of grapefruit juice on the bioactivation of prasugrel

scientific article published in June 2015

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

scientific article published on 8 October 2017

Enantiospecific Pharmacogenomics of Fluvastatin

scientific article published on 14 May 2019

Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.

scientific article published on 8 May 2013

Genome‐Wide Association Study of Atorvastatin Pharmacokinetics: Associations With <i>SLCO1B1</i>, <i>UGT1A3</i>, and <i>LPP</i>

scientific article published on 17 March 2024

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

scientific article published on 27 June 2014

Grapefruit juice inhibits the metabolic activation of clopidogrel

scientific article published on 25 September 2013

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

scientific article published on June 2013

High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population.

scientific article published on 2 April 2016

Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide

scientific article

Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records.

scientific article published on 27 June 2017

Itraconazole Increases Ibrutinib Exposure 10-Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug-Drug Interaction

scientific article published on 29 November 2019

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

article published in 2006

Placental transporter-mediated drug interactions and offspring congenital anomalies

scientific article published on 20 January 2020

Posaconazole‐ibrutinib interaction cannot be avoided by staggered dosing: How to optimize ibrutinib dose during posaconazole treatment

scientific article published on 13 November 2023

Response to "Influence of Diabetes on Antiplatelet Drug Efficacy"

scientific article published on 22 February 2018

Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?"

scientific article published on 17 September 2018

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

scientific article

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen

The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone

scientific article published on 11 July 2006

The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo

scientific article published on 26 March 2008

Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone

scientific article published on 3 October 2007

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