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List of works by Helena Karlström

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

scientific article

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

scientific article

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations

scientific article published on July 2003

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy

scientific article published in November 2012

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene

scientific article published in January 2012

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

scientific article

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

scientific article published on April 2004

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

scientific article published on 13 March 2018

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

scientific article published on 29 March 2004

Generalized potential of adult neural stem cells

scientific article (publication date: 2 June 2000)

Generation and phenotypic characterization of a galanin overexpressing mouse

scientific article published on 01 January 2005

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype

scientific article published in January 2005

Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain

scientific article published on 10 December 2010

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing

scientific article published on 18 July 2011

No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis

scientific article published in August 2007

Notch receptor cleavage depends on but is not directly executed by presenilins

scientific article

Presenilin dependence of phospholipase C and protein kinase C signaling.

scientific article

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production

scientific article

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.

scientific article published on November 2010

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing

scientific article

Variable phenotype of Alzheimer's disease with spastic paraparesis

scientific article published on 6 November 2007

Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase

scientific article

gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes

scientific article

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio

scientific article published on October 2011

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