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List of works by Holger Heyn

A Comprehensive DNA Methylation Profile of Epithelial-to-Mesenchymal Transition

scientific article published on 08 August 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

scientific article (publication date: 3 April 2014)

A DNA methylation map of human cancer at single base-pair resolution.

scientific article published on 05 June 2017

A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

article

A landscape of pharmacogenomic interactions in cancer.

scientific article published on 05 July 2016

A symbiotic liaison between the genetic and epigenetic code

scientific article published on May 2014

Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome ⬇️

scientific article published on December 20, 2012

Abstract 3883: Clonal evolution of a lethal prostate cancer: Integrated whole genome analysis case study

An Adenine Code for DNA: A Second Life for N6-Methyladenine

scientific article published on 30 April 2015

Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers

scientific article

Benchmarking single-cell RNA-sequencing protocols for cell atlas projects

scientific article published on 06 April 2020

Building a high-quality Human Cell Atlas ⬇️

journal article from 'Nature Biotechnology' published in 2021

Cancer network activity associated with therapeutic response and synergism

scientific article published on 24 August 2016

Comparative Analysis of Single-Cell RNA Sequencing Methods.

scientific article published on February 2017

Comparison of single-cell whole-genome amplification strategies

Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

scientific article published on 7 September 2017

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

scientific article published on 2 November 2016

CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer

scientific article published on 23 May 2012

DNA methylation contributes to natural human variation

scientific article published on August 2013

DNA methylation dynamics in human carotid plaques after cerebrovascular events

scientific article published on 18 June 2015

DNA methylation map of human atherosclerosis

scientific article published on 4 August 2014

DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker

scientific article

DNA methylation profiling in the clinic: applications and challenges ⬇️

scientific article published on 04 September 2012

DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia

scientific article

Distinct DNA methylomes of newborns and centenarians

scientific article

Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).

scientific article published in October 2017

Dynamics of DNA methylation in recent human and great ape evolution

scientific article

EZH2: an epigenetic gatekeeper promoting lymphomagenesis

scientific article published in May 2013

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

scientific article published on June 2015

Epigenetic disruption of the PIWI pathway in human spermatogenic disorders

scientific article

Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer

scientific article

Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs

scientific article published on 27 November 2015

Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis

scientific article published on 18 November 2013

Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia.

scientific article published on 27 March 2017

Epigenetic profiling joins personalized cancer medicine

scientific article published on June 2013

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

scientific article published on 26 August 2016

Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer.

scientific article published on 26 January 2016

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

scientific article published on 08 August 2019

Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia

scientific article published on 30 October 2012

Global epigenomic reconfiguration during mammalian brain development

scientific article (publication date: 9 August 2013)

Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.

scientific article published on 19 January 2016

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

scientific article published on 08 November 2018

Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment

scientific article published on 08 March 2021

Impaired DICER1 function promotes stemness and metastasis in colon cancer.

scientific article published on 7 October 2013

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

scientific article published on 24 July 2015

Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

scientific article published in April 2018

Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines

scientific article

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

scientific article published on 8 March 2017

MicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer development

scientific article published on 25 May 2011

MicroRNA miR-548d is a superior regulator in pancreatic cancer

scientific article published on March 2012

Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease

scientific article published on 08 December 2020

Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response

scientific article published on 21 March 2006

Novel insights into DNA methylation features in spermatozoa: stability and peculiarities

scientific article

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

scientific article published on 07 May 2018

Personalized Therapy—Epigenetic Profiling as Predictors of Prognosis and Response

article published in 2015

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease

scientific article

Quantitative Trait Loci Identify Functional Noncoding Variation in Cancer

scientific article

RANKL/RANK control Brca1 mutation-driven mammary tumors

scientific article published on 31 May 2016

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

scientific article published on 12 February 2020

Sampling artifacts in single-cell genomics cohort studies ⬇️

journal article from 'bioRxiv' published in 2020

Sampling time-dependent artifacts in single-cell genomics studies

scientific article published on 11 May 2020

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

scientific article published on 12 March 2019

Single cell expression analysis uncouples transdifferentiation and reprogramming

Single human oocyte transcriptome analysis reveals distinct maturation stage-dependent pathways impacted by age

scientific article published on 28 April 2021

Single-Cell Genomics Unravels Brain Cell-Type Complexity

scientific article published in January 2017

Single-Cell Transcriptomics Unveils Gene Regulatory Network Plasticity

article

Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

scientific article published on 01 April 2022

Single-cell transcriptome conservation in cryopreserved cells and tissues

scientific article published on March 2017

Single-cell transcriptomics unveils gene regulatory network plasticity.

scientific article published on 4 June 2019

Systematic benchmarking of single-cell ATAC-sequencing protocols

scientific article published in 2023

TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes

scientific article published on 28 November 2017

The DNA methylation drift of the atherosclerotic aorta increases with lesion progression

scientific article published on 27 February 2015

The NCI-60 Methylome and Its Integration into CellMiner

scientific article

The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation

scientific article published on 05 August 2020

The Role of the Genetic Code in the DNA Methylation Landscape Formation

The interplay between DNA methylation and sequence divergence in recent human evolution.

scientific article

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis

scientific article published on 01 July 2019

Tutorial: guidelines for the experimental design of single-cell RNA sequencing studies

scientific article published on 01 December 2018

Use of patient derived orthotopic xenograft models for real-time therapy guidance in a pediatric sporadic malignant peripheral nerve sheath tumor

scientific article published on 03 July 2020

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

scientific article published on June 2011

Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex.

scientific article published on 20 January 2017

Whole-genome bisulfite DNA sequencing of a DNMT3B mutant patient

scientific article

Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development

scientific article published in May 2017

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

scientific article published on 10 May 2020

bigSCale: an analytical framework for big-scale single-cell data.

scientific article

matchSCore: Matching Single-Cell Phenotypes Across Tools and Experiments

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