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List of works by Kim Orth

A MAM7 peptide-based inhibitor of Staphylococcus aureus adhesion does not interfere with in vitro host cell function

scientific article

A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis

scientific article published on 17 December 2019

A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity.

scientific article published on 19 August 2010

A chemical reporter for protein AMPylation

scientific article published on 7 October 2011

A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

scientific article published on 18 May 2020

A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption.

scientific article

A newly discovered post-translational modification--the acetylation of serine and threonine residues

scientific article published on 6 April 2007

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability

article

AMPylation is a new post-translational modiFICation.

scientific article published in June 2009

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling

scientific article

AMPylation of Rho GTPases subverts multiple host signaling processes

scientific article

AMPylation: Something Old is New Again

scientific article

Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus.

scientific article published on 10 October 2008

Acute Hepatopancreatic Necrosis Disease-Causing Vibrio parahaemolyticus Strains Maintain an Antibacterial Type VI Secretion System with Versatile Effector Repertoires

scientific article published on 21 April 2017

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

scientific article published on 17 July 2018

An interview with Kim Orth.

scientific article published on 12 June 2013

AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway

scientific article published in September 2006

Arp2/3-independent assembly of actin by Vibrio type III effector VopL.

scientific article

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

scientific article published in Journal of Biological Chemistry

Bile salt receptor complex activates a pathogenic type III secretion system

scientific article

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus.

scientific article

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

scientific article published on 01 April 2020

Cancer cell exosomes can initiate malignant cell transformation

Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry.

scientific article published on 24 February 2011

Characterization of a rabbit polyclonal antibody against threonine-AMPylation

scientific article

Cleavage of focal adhesion kinase by caspases during apoptosis

scientific journal article

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade ⬇️

scientific article published on March 1, 1998

Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria

scientific article published on 01 June 2022

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor ⬇️

scientific article published on August 15, 1992

Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays

scientific article

Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.

scientific article published on September 2002

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

article

De-AMPylation unmasked: modulation of host membrane trafficking

scientific article published on 11 October 2011

Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.

scientific article

ERK7 is an autoactivated member of the MAPK family

scientific journal article

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides

scientific article published on January 2013

Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection

scientific article published in 2022

Enzymes Involved in AMPylation and deAMPylation

scientific article published on 18 August 2017

Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies

scientific article published on 2 February 2018

Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.

scientific article published on 31 October 2017

Fido, a novel AMPylation domain common to fic, doc, and AvrB.

scientific article

Function of the Yersinia effector YopJ.

scientific article

Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands.

scientific article published on 20 September 2011

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

scientific article published on February 1991

Genetic instability in human ovarian cancer cell lines.

scientific article published on September 1994

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

scientific article published in October 1997

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1.

scientific article published on July 2014

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse.

scientific article published on 3 June 2009

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

scientific article published on 02 May 2019

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

scientific article published on November 2002

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

scientific article published on 28 May 2019

In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax

scientific article published on 26 January 2008

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel.

scientific article published on 22 June 2012

Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.

scientific article

Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus

scientific article

Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells

scientific article

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

scientific journal article

Lost after translation: post-translational modifications by bacterial type III effectors

scientific article published on April 2013

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance

scientific article published in Journal of Biological Chemistry

Manipulation of host membranes by bacterial effectors

scientific article published on 18 July 2011

Manipulation of kinase signaling by bacterial pathogens

scientific article published on 28 November 2011

Marker for type VI secretion system effectors

scientific article

Microbiology. A protein pupylation paradigm

scientific article

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.

scientific article published on August 1996

My winding trail while fulfilling my love for science and family.

scientific article published on 11 April 2018

Natural transformation of Vibrio parahaemolyticus: A rapid method to create genetic deletions

scientific article published on 19 March 2018

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

scientific article published in Journal of Biological Chemistry

Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death.

scientific article published on 25 January 2009

Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens.

scientific article

Ovarian Tumors Display Persistent Microsatellite Instability Caused by Mutation in the Mismatch Repair Gene hMSH-2 ⬇️

scientific article published on January 1, 1994

Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: a potential early step in drug resistance ⬇️

scientific article published on October 15, 1998

Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding

article

Proteolysis of Poly(ADP-Ribose) Polymerase by Caspase 3: Kinetics of Cleavage of Mono(ADP-Ribosyl)ated and DNA-Bound Substrates

scientific article published on July 1, 1998

Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus.

scientific article published on 26 July 2016

Purification of the Death Substrate Poly(ADP-ribose) Polymerase

article

Regulation of the Unfolded Protein Response by BiP AMPylation protects photoreceptors from light-dependent degeneration

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth.

scientific article published on 23 January 2018

Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses

scientific article published in April 2008

Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells.

scientific article published on 16 May 2017

Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum.

scientific article

Signaling network of paclitaxel-induced apoptosis in the LNCaP prostate cancer cell line.

scientific article published on October 1999

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

scientific article

Structural and antigenic conservation of the P2 porin protein among strains of Haemophilus influenzae type b.

scientific article

Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence

scientific article published on 31 October 2014

Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways

scientific article

Subversion of Cell Signaling by Pathogens ⬇️

scientific article published on September 1, 2012

Subversion of the cytoskeleton by intracellular bacteria: lessons from Listeria, Salmonella and Vibrio

scientific article published on 8 January 2015

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.

scientific article

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

scientific article

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

scientific journal article

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury

scientific article published on 20 December 2016

The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues.

scientific article published on 16 January 2018

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

scientific journal article

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

scientific article published on 16 May 2017

The elusive activity of the Yersinia protein kinase A kinase domain is revealed.

scientific article published on 24 October 2007

The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells

scientific article

The pore-forming bacterial effector, VopQ, halts autophagic turnover

scientific article

The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity ⬇️

scientific article published on November 4, 2012

Tipping the balance by manipulating post-translational modifications.

scientific article

Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent.

scientific article

Type III effector VopC mediates invasion for Vibrio species. ⬇️

scientific article

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

scientific article published on 25 August 2015

Type VI secretion system

scientific article published on 01 March 2015

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities.

scientific article published on 14 September 2017

Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor ⬇️

scientific article published on May 15, 1992

Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis.

scientific article

Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis

scientific article published on 14 July 2009

Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes

scientific article

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

scientific article published on 24 June 2013

Vibrio parahaemolyticus cell biology and pathogenicity determinants

scientific article

Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis.

scholarly article

Vibrio parahaemolyticus type VI secretion system 1 is activated in marine conditions to target bacteria, and is differentially regulated from system 2.

scientific article

Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins

scientific article

Virulence determinants for Vibrio parahaemolyticus infection.

scientific article published on 22 February 2013

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections.

scientific article published on June 2012

VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases

scientific article

What pathogens have taught us about posttranslational modifications

scientific article published on September 2013

Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta.

scientific article published in October 2003

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

scientific article

Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism.

scientific article published on 13 November 2002

Yersinia outer proteins: Yops

scientific article published on 11 December 2007

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