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List of works by Norihito Shintani

15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells.

scientific article published on 16 April 2010

A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells.

scientific article

Altered behavioral response to centrally acting drugs in mice lacking PACAP

scientific article

Altered higher brain function in PACAP-knockout mice

scientific article published in April 2004

An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice

scientific article

An enriched environment ameliorates memory impairments in PACAP-deficient mice

scientific article

Behavioral characterization of mice overexpressing human dysbindin-1.

scientific article

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice

scientific article published on 16 February 2015

Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model.

scientific article published on February 2014

Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner

scientific article published on 27 February 2013

Cerulein-induced acute pancreatitis in PACAP knockout mice

scientific article published on 22 June 2010

Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice.

scientific article published on 24 June 2015

Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice

scientific article published on 13 April 2010

Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells

scientific article published on 03 April 2012

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

scientific article

De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.

scientific article

Defects in reproductive functions in PACAP-deficient female mice.

scientific article published in November 2002

Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone.

scientific article

Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells.

scientific article published on March 2005

Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.

scientific article published on 27 October 2016

Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues.

scientific article

Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain

scientific article published in January 2010

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice.

scientific article published on 6 February 2010

First screening for behavioral phenotype of gene-engineered mice

scientific article published in October 2007

Functional roles of the neuropeptide PACAP in brain and pancreas.

scientific article

High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

scientific article published on December 2016

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

scientific article

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.

scientific article published on 23 January 2015

Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice ⬇️

scientific article published on November 14, 2003

In vivo functional analysis of the neuropeptide PACAP using gene-targeted mice ⬇️

scientific article published on November 1, 2003

Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice

scientific article

Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice.

scientific article published on 26 November 2009

Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations

scientific article

Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells

scientific article published on 01 July 2006

Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons

scientific article

Involvement of intracellular Ca2+ elevation but not cyclic AMP in PACAP-induced p38 MAP kinase activation in PC12 cells.

scientific article published in November 2002

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism

scientific article published on 25 January 2018

Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice

scientific article published on 01 July 2006

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

scientific article published on 08 October 2020

Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala.

scientific article published on 24 December 2011

Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo

scientific article published on 30 June 2011

Neuroprotective action of endogenous PACAP in cultured rat cortical neurons.

scientific article published in March 2005

New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice

scientific article published in July 2006

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

scientific article

Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice

scientific article published in August 2009

Overexpression of PACAP in the pancreas failed to rescue early postnatal mortality in PACAP-null mice.

scientific article published on December 2004

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.

scientific article published in May 2003

Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice.

scientific article published on 23 January 2004

PAC1 receptor-mediated relaxation of longitudinal muscle of the mouse proximal colon.

scientific article published in September 2002

PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density

scientific article published on 11 March 2013

PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells.

scientific article published in April 2004

PACAP centrally mediates emotional stress-induced corticosterone responses in mice.

scientific article published on 27 March 2011

PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.

scientific article published in November 2004

PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF.

scientific article published on 25 March 2015

PACAP is Implicated in the Stress Axes ⬇️

scientific article published on January 1, 2011

PACAP suppresses dry eye signs by stimulating tear secretion

scientific article

PACAP- and PHI-mediated sustained relaxation in circular muscle of gastric fundus: findings obtained in PACAP knockout mice.

scientific article published on 17 October 2005

PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset

scientific article

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

scientific article published on 26 February 2020

Phenotypic characterization of transgenic mice overexpressing neuregulin-1

scientific article

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation

scientific article published on 18 March 2019

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

scholarly article

Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.

scientific article

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

scientific article published on 13 November 2009

Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.

scientific article published on 29 July 2016

Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice

scientific article published on 01 May 2006

Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor.

scientific article published on 13 April 2010

Retardation of retinal vascular development in apelin-deficient mice

scientific article

Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: lessons from PACAP-deficient mice

scientific article

Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders.

scientific article published on 29 July 2012

Simultaneous neuron- and astrocyte-specific fluorescent marking.

scientific article published on 24 February 2015

The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide

scientific article published on 01 February 2011

The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation

scientific article

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide.

scientific article published in February 2013

Trophic effects of PACAP on pancreatic islets: a mini-review.

scientific article published on 20 July 2010

Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response.

scientific article published on 24 November 2017

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.

scientific article published on 19 November 2015

[Neuropeptide PACAP and neuropsychological function: unexpected insights from mouse mutants]

scientific article published on 01 April 2007

[Translational research for mental disorder -schizophrenia]

scientific article published on 01 February 2011

p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice

scientific journal article

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

scientific article

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