List of works - Rik J Lories

A Notch in the joint that exacerbates osteoarthritis

scientific article published on 01 October 2018

A comparative study on culture conditions and routine expansion of amniotic fluid-derived mesenchymal progenitor cells.

scientific article

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis

scientific article published on 22 August 2016

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone

scientific article published on 01 September 2018

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice

scientific article

Advances in understanding the pathophysiology of spondyloarthritis

scientific article published on 01 June 2018

Animal models of spondyloarthritis.

scientific article published on July 2006

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice

scientific article published on 01 December 2007

Autoimmune Diseases: Early Diagnosis and New Treatment Strategies

scientific article published on 03 July 2012

Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo.

scientific article published on 25 November 2011

Bone Disease in Axial Spondyloarthritis.

scientific article published on 31 October 2017

Bone formation in axial spondyloarthritis.

scientific article published on October 2014

Bone morphogenetic protein signaling and arthritis.

scientific article published on October 2009

CD248 and its cytoplasmic domain: a therapeutic target for arthritis

scientific article

CD248 facilitates tumor growth via its cytoplasmic domain. ⬇️

scientific article

CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis.

scientific article published on 14 January 2016

Changing the outcome of osteoarthritis: still a challenge for cyclooxygenase 2 inhibitors

scientific article published on 01 January 2012

Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression

scientific article published on 01 April 2013

Comorbidities Associated with Psoriatic Arthritis Compared with Non-psoriatic Spondyloarthritis: A Cross-sectional Study

scientific article published on 15 December 2015

Contemporary concepts of inflammation, damage and repair in rheumatic diseases.

scientific article published on October 2006

Cushioning the cartilage: a canonical Wnt restricting matter

scientific article published on 12 October 2017

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.

scientific article

Deletion of frizzled-related protein reduces voluntary running exercise performance in mice.

scientific article published on 26 September 2008

Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis.

scientific article published on 14 February 2008

Effect of Gut Involvement in Patients with High Probability of Early Spondyloarthritis: Data from the DESIR Cohort

scientific article published on 01 June 2019

Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis

scientific article published on 15 March 2015

Etoricoxib and the treatment of ankylosing spondylitis

scientific article

European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update

scientific article

Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter--Determining Validation Requirements.

scientific article published on June 2015

Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis

scientific article published on 15 November 2005

Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis

scientific article published on 01 February 2007

Evolution of psoriatic arthritis study patient population characteristics in the era of biological treatments

scientific article published on 22 January 2019

Fibrogenesis, novel lessons from animal models

scientific article published on 04 July 2015

Forced expiration measurements in mouse models of obstructive and restrictive lung diseases.

scientific article

Full thickness abdominal wall defect in growing rats as a model for congenital diaphragmatic hernia prosthetic repair.

scientific article published on 10 February 2014

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

scientific article published on 30 August 2010

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis.

scientific article published on 31 July 2012

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

scientific article published in August 2010

Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis

scientific article published on 13 June 2014

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

scientific journal article

IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis. Response to: 'Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut o

scientific article published on 29 July 2014

Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus.

scientific article published on May 2007

Inflammation and ankylosis: still an enigmatic relationship in spondyloarthritis

scientific article published on 01 March 2012

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

scientific article

International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphos

scientific article

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

scientific article published on June 2009

Longitudinal in vivo microcomputed tomography of mouse lungs: No evidence for radiotoxicity

scientific article published on 29 May 2015

Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume

scientific article published on 12 November 2015

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis

scientific article published on 30 October 2014

MAIT cells: not just another brick in the wall

scientific article published on 29 July 2016

Magnetic resonance imaging for noninvasive assessment of lung fibrosis onset and progression: cross-validation and comparison of different magnetic resonance imaging protocols with micro-computed tomography and histology in the bleomycin-induced mou

scientific article published in November 2014

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

scientific article published in Nature Communications

Mechanisms of pathologic new bone formation.

scientific article published on October 2006

Mechanisms, impact and prevention of pathological bone regeneration in spondyloarthritis

scientific article published on April 2017

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

scientific article

Microtrauma: no longer to be ignored in spondyloarthritis?

scientific article

Moving forward from drug-centred to patient-centred research: A white paper initiated by EORTC and developed together with the BioMed Alliance members

scientific article published on 21 February 2019

No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis

scientific article

No evidence for a direct role of HLA-B27 in pathological bone formation in axial SpA.

scientific article published on 29 June 2017

Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism

scientific article

Orthopaedic interventions in patients with psoriatic arthritis: a descriptive report from the SPAR cohort.

scientific article

Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain

scientific article published on 29 February 2016

Osteoimmunology: Wnt antagonists: for better or worse?

scientific article published in August 2009

Osteoporosis: a paradox in ankylosing spondylitis.

scientific article published on September 2011

Osteoprotegerin and osteoprotegerin-ligand balance: a new paradigm in bone metabolism providing new therapeutic targets.

scientific article

Perception and knowledge about stem cell and tissue engineering research: a survey amongst researchers and medical practitioners in perinatology.

scientific article published on August 2014

Polyclonal immunoglobulins for intravenous use induce interleukin 10 release in vivo and in vitro.

scientific article published in June 2004

Polymyalgia rheumatica/arteritis temporalis and acquired factor VIII inhibitor.

scientific article published on 11 January 2008

Preface

Primed for inflammation: enthesis-resident T cells

article published in 2012

Progress towards a molecular basis for joint surface repair

scientific article published on 18 March 2009

Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats

scientific article published on 01 January 2012

Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes.

scientific article published in July 2014

Pyoderma gangrenosum developing during therapy with TNF-alpha antagonists in a patient with rheumatoid arthritis

scientific article published on 18 September 2007

Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography

scientific article

Remission in psoriatic arthritis

scientific article published on 01 August 2008

Remission in psoriatic arthritis-where are we now? ⬇️

scientific article published on 16 October 2017

Review: animal models as a tool to dissect pivotal pathways driving spondyloarthritis.

scientific article published on 20 July 2015

Routine isolation and expansion late mid trimester amniotic fluid derived mesenchymal stem cells in a cohort of fetuses with congenital diaphragmatic hernia.

scientific article published on 19 April 2014

Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops

scientific article published on 30 March 2019

SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.

scientific article published on 13 June 2018

Safe and effective cryopreservation methods for long-term storage of human-amniotic-fluid-derived stem cells.

scientific article

Safety and Efficacy of Biological Disease-Modifying Antirheumatic Drugs in Older Rheumatoid Arthritis Patients: Staying the Distance

scientific article published on 6 May 2016

Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.

scientific article

Structural Disease Progression in Axial Spondyloarthritis: Still a Cause for Concern?

scientific article published on March 2017

Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo.

scientific article published on 30 November 2017

Targets, models and challenges in osteoarthritis research

scientific article

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis

scientific article

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

scientific article

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress

scientific article published on 30 December 2014

The influence of ageing on the development and management of rheumatoid arthritis

scientific article published on 18 June 2013

The kaleidoscopic presentation of the spondyloarthritis concept in a female patient

scientific article published on 23 June 2011

The pathogenesis of pulmonary fibrosis: a moving target

scientific article published on 25 October 2012

The role of bone morphogenetic proteins in ankylosing spondylitis.

scientific article published on August 2012

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

scientific article

Translation of clinical problems in osteoarthritis into pathophysiological research goals

scientific article published on 26 May 2016

Tumour necrosis factor inhibitors in the treatment of psoriatic arthritis: a view on effectiveness, clinical practice and toxicity

scientific article

Unusual cervical spine involvement in psoriatic arthritis: a case series.

scientific article published on 8 August 2009

Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women.

scientific article

WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician?

scientific article published on February 2009

List of works by Rik J Lories

A Notch in the joint that exacerbates osteoarthritis

A comparative study on culture conditions and routine expansion of amniotic fluid-derived mesenchymal progenitor cells.

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice

Advances in understanding the pathophysiology of spondyloarthritis

Animal models of spondyloarthritis.

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice

Autoimmune Diseases: Early Diagnosis and New Treatment Strategies

Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo.

Bone Disease in Axial Spondyloarthritis.

Bone formation in axial spondyloarthritis.

Bone morphogenetic protein signaling and arthritis.

CD248 and its cytoplasmic domain: a therapeutic target for arthritis

CD248 facilitates tumor growth via its cytoplasmic domain. ⬇️

CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis.

Changing the outcome of osteoarthritis: still a challenge for cyclooxygenase 2 inhibitors

Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression

Comorbidities Associated with Psoriatic Arthritis Compared with Non-psoriatic Spondyloarthritis: A Cross-sectional Study

Contemporary concepts of inflammation, damage and repair in rheumatic diseases.

Cushioning the cartilage: a canonical Wnt restricting matter

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.

Deletion of frizzled-related protein reduces voluntary running exercise performance in mice.

Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis.

Effect of Gut Involvement in Patients with High Probability of Early Spondyloarthritis: Data from the DESIR Cohort

Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis

Etoricoxib and the treatment of ankylosing spondylitis

European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update

Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter--Determining Validation Requirements.

Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis

Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis

Evolution of psoriatic arthritis study patient population characteristics in the era of biological treatments

Fibrogenesis, novel lessons from animal models

Forced expiration measurements in mouse models of obstructive and restrictive lung diseases.

Full thickness abdominal wall defect in growing rats as a model for congenital diaphragmatic hernia prosthetic repair.

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis.

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis. Response to: 'Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut o

Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus.

Inflammation and ankylosis: still an enigmatic relationship in spondyloarthritis

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphos

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

Longitudinal in vivo microcomputed tomography of mouse lungs: No evidence for radiotoxicity

Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis

MAIT cells: not just another brick in the wall

Magnetic resonance imaging for noninvasive assessment of lung fibrosis onset and progression: cross-validation and comparison of different magnetic resonance imaging protocols with micro-computed tomography and histology in the bleomycin-induced mou

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

Mechanisms of pathologic new bone formation.

Mechanisms, impact and prevention of pathological bone regeneration in spondyloarthritis

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Microtrauma: no longer to be ignored in spondyloarthritis?

Moving forward from drug-centred to patient-centred research: A white paper initiated by EORTC and developed together with the BioMed Alliance members

No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis

No evidence for a direct role of HLA-B27 in pathological bone formation in axial SpA.

Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism

Orthopaedic interventions in patients with psoriatic arthritis: a descriptive report from the SPAR cohort.

Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain

Osteoimmunology: Wnt antagonists: for better or worse?

Osteoporosis: a paradox in ankylosing spondylitis.

Osteoprotegerin and osteoprotegerin-ligand balance: a new paradigm in bone metabolism providing new therapeutic targets.

Perception and knowledge about stem cell and tissue engineering research: a survey amongst researchers and medical practitioners in perinatology.

Polyclonal immunoglobulins for intravenous use induce interleukin 10 release in vivo and in vitro.

Polymyalgia rheumatica/arteritis temporalis and acquired factor VIII inhibitor.

Preface

Primed for inflammation: enthesis-resident T cells

Progress towards a molecular basis for joint surface repair

Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats

Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes.

Pyoderma gangrenosum developing during therapy with TNF-alpha antagonists in a patient with rheumatoid arthritis

Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography

Remission in psoriatic arthritis

Remission in psoriatic arthritis-where are we now? ⬇️

Review: animal models as a tool to dissect pivotal pathways driving spondyloarthritis.

Routine isolation and expansion late mid trimester amniotic fluid derived mesenchymal stem cells in a cohort of fetuses with congenital diaphragmatic hernia.