List of works - Jun Sun

16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

scientific article

A human gut ecosystem protects against C. difficile disease by targeting TcdA.

scientific article published on 21 June 2016

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis

scientific article published on 01 January 2021

Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy.

scientific article

Administration of defined microbiota is protective in a murine Salmonella infection model.

scientific article published on 4 November 2015

Alcohol Injury Damages Intestinal Stem Cells

scientific article published on 14 February 2017

Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation

scientific article published on 28 April 2018

Artificial sweeteners are not sweet to the gut microbiome

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells

scientific article

Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function

scientific article published on October 2009

Bacterial activation of beta-catenin signaling in human epithelia

scientific article published on 5 February 2004

Bacterial protein AvrA stabilizes intestinal epithelial tight junctions via blockage of the C-Jun N-terminal kinase pathway

scientific article

Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences

scientific article published on 07 February 2017

Bio-printing cell-laden Matrigel-agarose constructs

scientific article published on 16 September 2016

CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia.

scientific article

Chronic Salmonella infected mouse model

scientific article

Chronic effects of a Salmonella type III secretion effector protein AvrA in vivo

scientific article

Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells

scientific article published on 03 June 2016

Clinicopathologic characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma.

scientific article

Consistent activation of the β-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine

scientific article

Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells

scientific article published on 24 March 2005

Cryptosporidium parvum disrupts intestinal epithelial barrier function via altering expression of key tight junction and adherens junction proteins

scientific article published on 14 February 2018

Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women

scientific article published in Scientific Reports

Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo

scientific article published on 10 June 2019

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation

scientific article

Developmentally regulated tumor necrosis factor-alpha induced nuclear factor-kappaB activation in intestinal epithelium

scientific article published on 15 February 2007

Dietary vitamin D, vitamin D receptor, and microbiome

Differential expression of 26S proteasome subunits and functional activity during neonatal development

scientific article

Dirty environment for adult life: The bad, the good, the unknown

Does the gut drive amyotrophic lateral sclerosis progress?

scientific article published on 19 October 2015

Editorial [Hot topic: Microbiota, Innate Immune and Anti-Inflammation (Guest Editor: Jun Sun)]

Enteric Bacteria and Cancer Stem Cells ⬇️

scientific article published on January 1, 2010

Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway

scientific article

Environmental immune disruptors, inflammation and cancer risk

scientific article

Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis

scientific article

Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis

scientific article

Eukaryotic signaling pathways targeted by Salmonella effector protein AvrA in intestinal infection in vivo

scientific article

Evaporation-based microfluidic production of oil-free cell-containing hydrogel particles

scientific article published on 27 March 2015

Exploring gut microbes in human health and disease: Pushing the envelope

scientific article

Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium

scientific article published on 17 January 2008

Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells.

scientific article published on 30 November 2006

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

scientific article

Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Gut inflammation and dysbiosis in human motor neuron disease

scientific article published on September 2017

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

scientific article published on 08 July 2020

Gut microbiota, inflammation and colorectal cancer

scientific article

HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice.

scientific article

HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice

scientific article published on 3 April 2014

Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection

scientific article published on 12 December 2017

High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5.

scientific article

High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7

scientific article published on 9 July 2015

Host-microbiota interaction and intestinal stem cells in chronic inflammation and colorectal cancer

scientific article

Hypothesis Testing and Statistical Analysis of Microbiome

Imbalance of the intestinal virome and altered viral-bacterial interactions caused by a conditional deletion of the vitamin D receptor

scientific article published on 01 January 2021

Immunogenicity and protective efficacy of a Salmonella Enteritidis sptP mutant as a live attenuated vaccine candidate

scientific article

Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor

scientific article

Infection in Chronic Inflammation and Gastrointestinal Cancer

scientific article published on 10 March 2019

Infection with enteric pathogens Salmonella typhimurium and Citrobacter rodentium modulate TGF-beta/Smad Signaling Pathways in the Intestine

scientific article published on 30 January 2018

Inflammation and intestinal leakiness in older HIV+ individuals with fish oil treatment

article

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

scientific article published on 03 October 2019

Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation

scientific article published on 31 March 2017

Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates

scientific article published on 14 March 2018

Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy

scientific article published on 09 April 2019

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

scientific article

Intestinal organoid as an in vitro model in studying host-microbial interactions

article

Involvement of the vitamin D receptor in the regulation of NF-kappaB activity in fibroblasts

scientific article published on 23 December 2006

Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome

scientific article published on May 2015

Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses

article

Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic pigs

scientific article published on December 2013

Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model

scientific article published on April 2015

Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells

scientific article published on 25 April 2008

Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion

scientific article

Novel Regulatory Roles of Wnt1 in Infection-Associated Colorectal Cancer

scientific article published on 4 April 2018

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

scientific article published on 25 October 2007

Nutritional Correlates of Human Oral Microbiome

scientific article

Oral administration of transforming growth factor-β1 (TGF-β1) protects the immature gut from injury via Smad protein-dependent suppression of epithelial nuclear factor κB (NF-κB) signaling and proinflammatory cytokine production

scientific article published on 15 October 2013

Oral microbiome and history of smoking and colorectal cancer

scientific article published on October 2016

Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host

scientific article published on September 2009

Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells

scientific article published on 13 March 2008

Presence of Salmonella AvrA in colorectal tumor and its precursor lesions in mouse intestine and human specimens

scientific article published on 6 July 2017

Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model

scientific article

Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine

scientific article published on 07 August 2013

Probiotics, nuclear receptor signaling, and anti-inflammatory pathways

scientific article

Pulmonary permeability assessed by fluorescent-labeled dextran instilled intranasally into mice with LPS-induced acute lung injury

scientific article

Rebooting the microbiome

scientific article published on 13 May 2016

STAT3 activation in infection and infection-associated cancer

scientific article published on 18 February 2017

Salmonella Protein AvrA Activates the STAT3 Signaling Pathway in Colon Cancer

scientific article published on May 2016

Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination

scientific article

Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway

scientific article published on 15 November 2016

Salmonella infection upregulates the leaky protein claudin-2 in intestinal epithelial cells

scientific article

Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathway

scientific article

Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells

scientific article

Salmonella typhimurium infection increases p53 acetylation in intestinal epithelial cells

scientific article

Salmonella-infected crypt-derived intestinal organoid culture system for host-bacterial interactions

scientific article published on 11 September 2014

Signature-tagged mutagenesis screening revealed a novel smooth-to-rough transition determinant of Salmonella enterica serovar Enteritidis.

scientific article

Signature-tagged mutagenesis screening revealed the role of lipopolysaccharide biosynthesis gene rfbH in smooth-to-rough transition in Salmonella Enteritidis

article

Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells

scientific article published on March 2013

Study Bacteria-Host Interactions Using Intestinal Organoids

scientific article published on 19 August 2016

Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression

scientific article

Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis-like intestinal injury

scientific article

Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral Sclerosis

scientific article published on 24 January 2017

The Gli1-Snail axis contributes to Salmonella Typhimurium-induced disruption of intercellular junctions of intestinal epithelial cells

scientific article published on 23 April 2020

The Role of Vitamin D and Vitamin D Receptors in Colon Cancer

scientific article

The Vitamin D Receptor, Inflammatory Bowel Diseases, and Colon Cancer

scientific article published on March 2012

The inflammatory cytokine tumor necrosis factor modulates the expression of Salmonella typhimurium effector proteins

scientific article

The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart

scientific article published on 13 November 2017

Tight junction CLDN2 gene is a direct target of the vitamin D receptor

scientific article

Toll-like receptor signalling cross-activates the autophagic pathway to restrict Salmonella Typhimurium growth in macrophages

scientific article published on 26 August 2019

Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium

scientific article published on 19 January 2018

VDR/vitamin D receptor regulates autophagic activity through ATG16L1.

scientific article published on 28 July 2015

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

scientific article published on 31 December 2020

Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs

Vitamin D and mucosal immune function

scientific article

Vitamin D receptor deletion leads to reduced level of IkappaBalpha protein through protein translation, protein-protein interaction, and post-translational modification

scientific article

Vitamin D receptor is a novel transcriptional regulator for Axin1.

scientific article published on 3 September 2016

Vitamin D receptor is highly expressed in precancerous lesions and esophageal adenocarcinoma with significant sex difference

scientific article published on 15 May 2014

Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine

scientific article

Vitamin D receptor pathway is required for probiotic protection in colitis

scientific article published on 9 July 2015

Vitamin D receptor promotes healthy microbial metabolites and microbiome

scientific article published on 30 April 2020

Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases

scientific article

Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells

scientific article published on 8 September 2011

Wnt2 inhibits enteric bacterial-induced inflammation in intestinal epithelial cells

scientific article published on 14 June 2011

beta-Catenin activity negatively regulates bacteria-induced inflammation

scientific article published on 26 March 2007

tRNA Queuosine Modification Enzyme Modulates the Growth and Microbiome Recruitment to Breast Tumors

scientific article published on 09 March 2020

List of works by Jun Sun

16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

A human gut ecosystem protects against C. difficile disease by targeting TcdA.

Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis

Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy.

Administration of defined microbiota is protective in a murine Salmonella infection model.

Alcohol Injury Damages Intestinal Stem Cells

Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation

Artificial sweeteners are not sweet to the gut microbiome

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells

Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function

Bacterial activation of beta-catenin signaling in human epithelia

Bacterial protein AvrA stabilizes intestinal epithelial tight junctions via blockage of the C-Jun N-terminal kinase pathway

Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences

Bio-printing cell-laden Matrigel-agarose constructs

CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia.

Chronic Salmonella infected mouse model

Chronic effects of a Salmonella type III secretion effector protein AvrA in vivo

Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells

Clinicopathologic characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma.

Consistent activation of the β-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine

Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells

Cryptosporidium parvum disrupts intestinal epithelial barrier function via altering expression of key tight junction and adherens junction proteins

Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women

Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation

Developmentally regulated tumor necrosis factor-alpha induced nuclear factor-kappaB activation in intestinal epithelium

Dietary vitamin D, vitamin D receptor, and microbiome

Differential expression of 26S proteasome subunits and functional activity during neonatal development

Dirty environment for adult life: The bad, the good, the unknown

Does the gut drive amyotrophic lateral sclerosis progress?

Editorial [Hot topic: Microbiota, Innate Immune and Anti-Inflammation (Guest Editor: Jun Sun)]

Enteric Bacteria and Cancer Stem Cells ⬇️

Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway

Environmental immune disruptors, inflammation and cancer risk

Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis

Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis

Eukaryotic signaling pathways targeted by Salmonella effector protein AvrA in intestinal infection in vivo

Evaporation-based microfluidic production of oil-free cell-containing hydrogel particles

Exploring gut microbes in human health and disease: Pushing the envelope

Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium

Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells.

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Gut inflammation and dysbiosis in human motor neuron disease

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

Gut microbiota, inflammation and colorectal cancer

HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice.

HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice

Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection

High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5.

High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7

Host-microbiota interaction and intestinal stem cells in chronic inflammation and colorectal cancer

Hypothesis Testing and Statistical Analysis of Microbiome

Imbalance of the intestinal virome and altered viral-bacterial interactions caused by a conditional deletion of the vitamin D receptor

Immunogenicity and protective efficacy of a Salmonella Enteritidis sptP mutant as a live attenuated vaccine candidate

Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor

Infection in Chronic Inflammation and Gastrointestinal Cancer

Infection with enteric pathogens Salmonella typhimurium and Citrobacter rodentium modulate TGF-beta/Smad Signaling Pathways in the Intestine

Inflammation and intestinal leakiness in older HIV+ individuals with fish oil treatment

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation

Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates

Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

Intestinal organoid as an in vitro model in studying host-microbial interactions

Involvement of the vitamin D receptor in the regulation of NF-kappaB activity in fibroblasts

Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome

Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses

Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic pigs

Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model

Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells

Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion

Novel Regulatory Roles of Wnt1 in Infection-Associated Colorectal Cancer

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

Nutritional Correlates of Human Oral Microbiome

Oral administration of transforming growth factor-β1 (TGF-β1) protects the immature gut from injury via Smad protein-dependent suppression of epithelial nuclear factor κB (NF-κB) signaling and proinflammatory cytokine production

Oral microbiome and history of smoking and colorectal cancer