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List of works by Carmen Blanco-Aparicio

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The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

scientific article published on May 2008
PTEN, more than the AKT pathway

scientific article published on 6 March 2007
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

scientific article
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

scientific article
The PIM family of serine/threonine kinases in cancer

scientific article published on 10 April 2013
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article
Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities

scientific article published on 05 October 2012
PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

scientific article published on 21 September 2011
Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53

scientific article published on 01 February 2007
Levels of p27(kip1) determine Aplidin sensitivity

scientific article published on April 2007
Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth

scientific article published on May 15, 1998
Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

scientific article
S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

scientific article published on 19 August 2008
Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

scientific article published on 13 May 2015
Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

scientific article
Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

scientific article published on 3 November 2010
MAP17 overexpression is a common characteristic of carcinomas

scientific article
MAP17 enhances the malignant behavior of tumor cells through ROS increase

scientific article
Protein similarities beyond disulphide bridge topology

scientific article published on 01 December 1998
Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

scientific article
Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.

scientific article
The essential role of PIM kinases in sarcoma growth and bone invasion

scientific article published on 22 May 2012
p38α limits the contribution of MAP17 to cancer progression in breast tumors

scientific article published on 23 January 2012
Genetic modelling of the PTEN/AKT pathway in cancer research

scientific article published on October 2008
Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

scientific article
Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia

scientific article
A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

scientific article
Inhibiting PI3K as a therapeutic strategy against cancer

scientific article published on September 2009
Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.

scientific article
Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

scientific article published in November 2017
Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

scientific article published on 27 March 2018
Modulation of telomere protection by the PI3K/AKT pathway

scientific article published on 2 November 2017
Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

scientific article published on 19 March 2007
Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

scientific article published on 19 May 2011
Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

scientific article published on 24 October 2014
Disruptive chemicals, senescence and immortality

scientific article
Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker

scientific article
Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

scientific article published on October 2005
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

scientific article
PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

scientific article
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

scientific article
Spinophilin loss contributes to tumorigenesis in vivo

scientific article published on 15 June 2011
The role of PIM1/PIM2 kinases in tumors of the male reproductive system

scientific article (publication date: 30 November 2016)
Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

scientific article published on 22 July 2017
ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

scientific article published on 13 February 2016
Multiple cancer pathways regulate telomere protection

scientific article published on 13 June 2019
Lysosomal trapping of palbociclib and its functional implications

scientific article published on 28 January 2019
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

scientific article published on 28 September 2020
Correction: Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia.

scientific article

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