List of works - Carmen Blanco-Aparicio

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

scientific article published on 17 February 2022

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

scientific article

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

scientific article

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

scientific article

Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma

scientific article published on 01 January 2020

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia

scientific article

Correction: Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia.

scientific article

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

scientific article published on 19 February 2019

Disruptive chemicals, senescence and immortality

scientific article

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

scientific article published on 19 May 2011

ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

scientific article published on 13 February 2016

Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

scientific article published on 27 March 2018

Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

scientific article

Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53

scientific article published on 01 February 2007

Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.

scientific article

Genetic modelling of the PTEN/AKT pathway in cancer research

scientific article published on October 2008

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

scientific article published on 28 September 2020

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

scientific article

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

scientific article

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

scientific article published on 04 July 2020

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

scientific article published on 22 July 2017

Inhibiting PI3K as a therapeutic strategy against cancer

scientific article published on September 2009

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

scientific article published in November 2017

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

scientific article published on October 2005

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

scientific article

Levels of p27(kip1) determine Aplidin sensitivity

scientific article published on April 2007

Lysosomal trapping of palbociclib and its functional implications

scientific article published on 28 January 2019

MAP17 enhances the malignant behavior of tumor cells through ROS increase

scientific article

MAP17 overexpression is a common characteristic of carcinomas

scientific article

Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker

scientific article

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

Modulation of telomere protection by the PI3K/AKT pathway

scientific article published on 2 November 2017

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

scientific article published on 19 March 2007

Multiple cancer pathways regulate telomere protection

scientific article published on 13 June 2019

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

scientific article published on 24 October 2014

PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

scientific article

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

scientific article published on 21 September 2011

PTEN, more than the AKT pathway

scientific article published on 6 March 2007

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

scientific article published on 3 November 2010

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities ⬇️

scientific article published on 05 October 2012

Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth ⬇️

scientific article published on May 15, 1998

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

scientific article published on 10 February 2020

Protein similarities beyond disulphide bridge topology

scientific article published on 01 December 1998

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

scientific article

Regulation of MAPK cascades by protein tyrosine phosphatases.

scientific article published on January 2004

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

scientific article published on 19 August 2008

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

scientific article published on 20 September 2019

Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.

scientific article

Spinophilin loss contributes to tumorigenesis in vivo

scientific article published on 15 June 2011

The PIM family of serine/threonine kinases in cancer

scientific article published on 10 April 2013

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

scientific article published on May 2008

The essential role of PIM kinases in sarcoma growth and bone invasion

scientific article published on 22 May 2012

The mTOR pathway is necessary for survival of mice with short telomeres

scientific article published on 03 March 2020

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

scientific article (publication date: 30 November 2016)

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

scientific article published on 28 November 2019

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

scientific article published on 13 May 2015

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

scientific article

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

scientific article

p38α limits the contribution of MAP17 to cancer progression in breast tumors

scientific article published on 23 January 2012

List of works by Carmen Blanco-Aparicio

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia

Correction: Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia.

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

Disruptive chemicals, senescence and immortality

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53

Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.

Genetic modelling of the PTEN/AKT pathway in cancer research

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

Inhibiting PI3K as a therapeutic strategy against cancer

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

Levels of p27(kip1) determine Aplidin sensitivity

Lysosomal trapping of palbociclib and its functional implications

MAP17 enhances the malignant behavior of tumor cells through ROS increase

MAP17 overexpression is a common characteristic of carcinomas

Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

Modulation of telomere protection by the PI3K/AKT pathway

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

Multiple cancer pathways regulate telomere protection

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

PTEN, more than the AKT pathway

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities ⬇️

Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth ⬇️

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

Protein similarities beyond disulphide bridge topology

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

Regulation of MAPK cascades by protein tyrosine phosphatases.

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.

Spinophilin loss contributes to tumorigenesis in vivo

The PIM family of serine/threonine kinases in cancer

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

The essential role of PIM kinases in sarcoma growth and bone invasion

The mTOR pathway is necessary for survival of mice with short telomeres

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

p38α limits the contribution of MAP17 to cancer progression in breast tumors