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List of works by Miguel A. Castanho

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood-Brain Barrier Model.

scientific article published on 18 October 2017

A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography.

scientific article

A focus on glucose-mediated drug delivery to the central nervous system.

scientific article published on April 2012

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion

scientific article published in 2013

A photophysical study of the polyene antibiotic filipin. Self-aggregation and filipin--ergosterol interaction.

scientific article

Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol

scientific article published on 01 January 1992

Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

scientific article

An insight on the leading HIV entry inhibitors.

scientific article published on January 2006

An overview of the biophysical applications of atomic force microscopy.

scientific article published on February 2004

Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein

scientific article published on 15 December 2020

Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes.

scientific article published in February 2011

Antibody Approaches To Treat Brain Diseases

Anticancer Peptides: Prospective Innovation in Cancer Therapy

article

Anticancer peptide SVS-1: efficacy precedes membrane neutralization

scientific article

Antimicrobial peptide rBPI21: a translational overview from bench to clinical studies

scientific article published in November 2012

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations.

scientific article published in March 2009

Antimicrobial protein rBPI21-induced surface changes on Gram-negative and Gram-positive bacteria

scientific article published on 18 November 2013

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

scientific article

Arginine-rich self-assembling peptides as potent antibacterial gels

scientific article

Biomedical applications of dipeptides and tripeptides.

scientific article published on January 2012

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

scientific article published on 21 September 2016

Biophysics meets membrane-active peptides

scientific article published on 01 April 2008

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides.

scientific article published on 08 March 2017

Brownian dynamics simulation of the unsaturated lipidic molecules oleic and docosahexaenoic acid confined in a cellular membrane

scientific article published in September 2002

Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties

scientific article published on 21 August 2019

Cell-penetrating peptides and antimicrobial peptides: how different are they?

scientific article published on October 2006

Cell-penetrating peptides: A tool for effective delivery in gene-targeted therapies

scientific article published on 23 March 2014

Challenging metastatic breast cancer with the natural defensin PvD1.

scientific article published on 27 October 2017

Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia.

scientific article

Chiral Recognition ofD-Kyotorphin by Lipidic Membranes: Relevance Toward Improved Analgesic Efficiency

article

Conformation and dynamic properties of a saturated hydrocarbon chain confined in a model membrane: a Brownian dynamics simulation

scientific article published on 01 January 2000

Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-membrane interactions potentiating its action

scientific article

Consequences of Nonlytic Membrane Perturbation to the Translocation of the Cell Penetrating Peptide Pep-1 in Lipidic Vesicles†

scientific article published on 01 August 2004

Continuous particle size distribution analysis with dynamic light scattering. MAXAMPER: a regularization method using the maximum amplitude for the average error and the Lagrange's multipliers method.

scientific article published in June 1998

Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives.

scientific article published in January 2015

DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier

scientific article published on 12 February 2020

Decoding distinct membrane interactions of HIV-1 fusion inhibitors using a combined atomic force and fluorescence microscopy approach ⬇️

scientific article published on March 15, 2013

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

scientific article

Dengue Virus Capsid Protein Interacts Specifically with Very Low-Density Lipoproteins

scientific article published in January 2014

Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins

scientific article published on 30 November 2011

Dengue virus capsid protein interacts specifically with very low-density lipoproteins

scientific article published on 20 June 2013

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria.

scientific article

Developing students' awareness of public understanding of science: A matter of survival?

scientific article

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

scientific article

Does aliphatic chain length influence carbocyanines' orientation in supported lipid multilayers?

scientific article published in May 2004

Dps from Deinococcus radiodurans: oligomeric forms of Dps1 with distinct cellular functions and Dps2 involved in metal storage.

scientific article published on 20 August 2015

Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane

scientific article published on 14 September 2018

Effects of Diabetes on Microcirculation and Leukostasis in Retinal and Non-Ocular Tissues: Implications for Diabetic Retinopathy

scientific article published on 21 November 2020

Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture

scientific article published on 17 March 2015

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation.

scientific article published on 31 May 2016

Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1

scientific article published on 01 July 2007

Enfuvirtide effects on human erythrocytes and lymphocytes functional properties.

scientific article published in April 2008

Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells

scientific article published on 19 December 2019

Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR

scientific article published on 21 June 2010

Evaluation of lipopolysaccharide aggregation by light scattering spectroscopy.

scientific article published on January 2003

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

scientific article published on August 2012

Fast NMR method to probe solvent accessibility and disordered regions in proteins

scientific article published in Scientific Reports

Fast membrane association is a crucial factor in the peptide pep-1 translocation mechanism: a kinetic study followed by surface plasmon resonance

scientific article published in January 2010

Filipin and its interaction with cholesterol in aqueous media studied using static and dynamic light scattering

scientific article published on 01 April 1994

Filipin fluorescence quenching by spin-labeled probes: studies in aqueous solution and in a membrane model system

scientific article published on July 1995

Filipin orientation revealed by linear dichroism. Implication for a model of action.

scientific article published in May 2004

Filipin-induced lesions in planar phospholipid bilayers imaged by atomic force microscopy

scientific article

Fluorescence quenching data interpretation in biological systems. The use of microscopic models for data analysis and interpretation of complex systems

scientific article

Fluorescence study of a derivatized diacylglycerol incorporated in model membranes

scientific article published on 01 January 1994

Fold-unfold transitions in the selectivity and mechanism of action of the N-terminal fragment of the bactericidal/permeability-increasing protein (rBPI(21)).

scientific article published on February 2009

From antimicrobial to anticancer peptides. A review

scientific article published on October 2013

Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide

scientific article published on 15 June 2016

Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates.

scientific article published on 5 August 2016

HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes

scientific article

Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2.

scientific article

How to address CPP and AMP translocation? Methods to detect and quantify peptide internalization in vitro and in vivo (Review).

scientific article

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure.

scientific article published on 23 January 2014

In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence

scientific article published on 12 October 2016

In vitro blood-brain barrier models--latest advances and therapeutic applications in a chronological perspective.

scientific article published on March 2010

Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

scientific article published on July 2011

Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering

scientific article

Interaction of antimicrobial peptides, BP100 and pepR, with model membrane systems as explored by Brownian dynamics simulations on a coarse-grained model

scientific article published on 01 January 2012

Interaction of the Dengue virus fusion peptide with membranes assessed by NMR: The essential role of the envelope protein Trp101 for membrane fusion

scientific article published on 17 July 2009

Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein

scientific article

Is PrP(106-126) fragment involved in the membrane activity of the Prion protein?

scientific article published on August 2010

Joint determination by Brownian dynamics and fluorescence quenching of the in-depth location profile of biomolecules in membranes

scientific article published in August 2002

Lipid membrane-induced optimization for ligand-receptor docking: recent tools and insights for the "membrane catalysis" model.

scientific article

Lipidic membranes are potential "catalysts" in the ligand activity of the multifunctional pentapeptide neokyotorphin.

scientific article

Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX.

scientific article published on 27 March 2017

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15-34), antimicrobial peptides from rattlesnake venom

scientific article published on 18 December 2017

Meeting Report â Biochemical Education at the University Level, Lisbon, Portugal, October 30â 31, 1999

article

Molecular interaction studies of peptides using steady-state fluorescence intensity. Static (de)quenching revisited.

scientific article published on April 2008

Monitoring antibacterial permeabilization in real time using time-resolved flow cytometry

scientific article published on 10 November 2014

N-terminal AH2 segment of protein NS4B from hepatitis C virus. Binding to and interaction with model biomembranes.

scientific article published on 29 April 2013

Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer's Disease Patients: Potential Diagnostic and Pharmacological Implications.

scientific article published on 30 October 2013

Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action.

scientific article published on 4 May 2017

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

scientific article published on 4 May 2017

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood-Brain Barrier through a Receptor-Free Mechanism

scientific article published on 6 March 2017

Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action

scientific article published on 28 November 2013

Omiganan interaction with bacterial membranes and cell wall models. Assigning a biological role to saturation

scientific article published on 17 February 2007

Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides

scientific article published on June 2006

Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy

scientific article published on 04 July 2019

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

scientific article published on 22 April 2021

Peptibodies: An elegant solution for a long-standing problem.

scientific article published on 21 December 2017

Peptide Drug Discovery and Development

article

Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid

scientific article published on July 2013

Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives.

scientific article published on January 2016

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

scientific article

Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes

scientific article published on 03 December 2019

PrP(106-126) does not interact with membranes under physiological conditions

scientific article

Prediction of antibacterial activity from physicochemical properties of antimicrobial peptides.

scientific article

Preface: The invitation of the CERC3 to organize a "Young Chemists' Workshop"

scientific article published on 01 January 2006

Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level

scientific article published on January 2004

Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods.

scientific article

Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems

scientific article published on 16 January 2013

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

scientific article published on 30 March 2017

Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies.

scientific article published on 18 July 2010

Receptors and routes of dengue virus entry into the host cells

scientific article published on 22 December 2014

Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection

scientific article published on 11 April 2015

Rod-like cholesterol micelles in aqueous solution studied using polarized and depolarized dynamic light scattering

scientific article

Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

scientific article

Shiga toxin B-subunit sequential binding to its natural receptor in lipid membranes

scientific article published on 23 December 2006

Sifuvirtide screens rigid membrane surfaces. establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides.

scientific article published on 15 April 2008

Simulation of the distribution and diffusion of a rigid amphipathic particle embedded in a model membrane

scientific article published on 01 May 1999

Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors

scientific article

Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

scientific article published on 13 June 2016

Structural characterization of organized systems of polysaccharides and phospholipids by light scattering spectroscopy and electron microscopy

article by Nuno C. Santos et al published May 1997 in Carbohydrate Research

Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

scientific article published on 24 September 2018

Synergistic effects of the membrane actions of cecropin-melittin antimicrobial hybrid peptide BP100

scientific article

Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity

scientific article published on 26 June 2019

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates

scientific article published in 2022

Teaching light scattering spectroscopy: the dimension and shape of tobacco mosaic virus

scientific article

The Application of Biophysical Techniques to Study Antimicrobial Peptides

article published in 2012

The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization

scientific article published on 17 November 2020

The Mechanism of Action of Antimicrobial Peptides: Lipid Vesicles vs. Bacteria

scientific article published on 2 August 2012

The Use of Visual Analog Scales to Compare Pain Between Patients With Alzheimer's Disease and Patients Without Any Known Neurodegenerative Disease and Their Caregivers

scientific article

The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism.

scientific article published on 7 September 2015

The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability

scientific article

The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif

scientific article

The influence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers

article

The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

scientific article published on 01 September 2019

The mechanisms and quantification of the selective permeability in transport across biological barriers: the example of kyotorphin.

scientific article published on February 2014

The membranes' role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation.

scientific article published on 24 February 2006

The pentaene macrolide antibiotic filipin prefers more rigid DPPC bilayers: a fluorescence pressure dependence study

scientific article published on 01 June 1999

The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide

article

The toxicity of prion protein fragment PrP(106-126) is not mediated by membrane permeabilization as shown by a M112W substitution

scientific article published in May 2009

The transverse location of the fluorescent probe trans-parinaric acid in lipid bilayers

scientific article published on 01 March 1996

Translocating the blood-brain barrier using electrostatics

scientific article published on 11 October 2012

Translocation or membrane disintegration? Implication of peptide-membrane interactions in pep-1 activity

scientific article published on April 2008

Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets

scientific article published on 10 July 2015

Understanding dengue virus capsid protein disordered N-Terminus and pep14-23-based inhibition

scientific article published on 20 November 2014

Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes.

scientific article published on 11 February 2010

Using zeta-potential measurements to quantify peptide partition to lipid membranes

scientific article published on 13 January 2011

What can light scattering spectroscopy do for membrane-active peptide studies?

scientific article published on April 2008

Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions.

scientific article

rBPI(21) promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes

scientific article

rBPI21 interacts with negative membranes endothermically promoting the formation of rigid multilamellar structures.

scientific article published on 18 June 2013

siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model.

scientific article published on 24 November 2016

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