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List of works by Dominik Sturm

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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article (publication date: 29 January 2012)
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

scientific article published in October 2012
Dissecting the genomic complexity underlying medulloblastoma

scientific article
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

scientific article
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

scientific article
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

scientific article published on February 2014
DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article
The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

scientific article
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

scientific article published on 23 June 2013
Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

scientific article published on 24 October 2013
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

scientific article
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

scientific article published on 16 February 2013
Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

scientific article published on 10 March 2015
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

scientific article
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

scientific article published on 14 March 2017
Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

scientific article published on 10 July 2014
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

scientific article published on 17 May 2010
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

scientific article
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma

scientific article
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

scientific article published on 15 December 2015
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

scientific article
Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail

scientific article published on March 1, 2013
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015
Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

scientific article published on 4 August 2017
Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles

scientific article published on 15 December 2014
Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management.

scientific article
Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.

scientific article
Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics

scientific article published on 20 July 2013
Evidence of H3 K27M mutations in posterior fossa ependymomas

scientific article
Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

scientific article published on 19 October 2015
Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries

scientific article
H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

scientific article published on 11 April 2017
Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

scientific article published on 21 January 2017
Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group.

scientific article
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations

scientific article
Integrated molecular characterization of IDH-mutant glioblastomas

scientific article published on 15 November 2018
Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

scientific article
Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases

scientific article
No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.

scientific article published on April 2016
The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

scientific article published on April 2017
Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis

scientific article published on 2 September 2013
Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

scientific article published on 4 May 2017
Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018
Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article published in Nature

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