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List of works by Benoit Coulombe

A Human RNA Polymerase II-containing Complex Associated with Factors Necessary for Spliceosome Assembly ⬇️

scientific article published on December 31, 2001

A Web Resource for Improved Analysis of AP-MS Protein Interaction Data

scientific article published in May 2013

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

scientific article

A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts

scientific article published on 11 March 2015

Abnormal expression of RNA polymerase II-associated proteins in muscle of patients with myofibrillar myopathies

scientific article published on 17 April 2015

Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation

scientific article

Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4

scientific article

Analysis of the SARS-CoV-2-host protein interaction network reveals new biology and drug candidates: focus on the spike surface glycoprotein and RNA polymerase ⬇️

journal article from 'Expert Opinion on Drug Discovery' published in 2021

Basal expression of the gene (TIMP) encoding the murine tissue inhibitor of metalloproteinases is mediated through AP1- and CCAAT-binding factors ⬇️

scientific article published on July 15, 1992

Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy

scientific article published on 15 March 2018

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

scientific article

Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse

scientific article

Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase

scientific article

DNA bending and wrapping around RNA polymerase: a "revolutionary" model describing transcriptional mechanisms.

scientific article

DNA wrapping in transcription initiation by RNA polymerase II

scientific article

De novo variants in POLR3B cause ataxia, spasticity, and demyelinating neuropathy

scientific article published on 01 January 2021

Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity ⬇️

scientific article published on April 15, 1991

Defining protein interactions that regulate disease progression

scientific article published on 01 January 2009

Detection of locally over-represented GO terms in protein-protein interaction networks

scientific article

Discovery of Antivirals Using Phage Display ⬇️

journal article from 'Viruses' published in 2021

Discovery of cell compartment specific protein-protein interactions using affinity purification combined with tandem mass spectrometry

scientific article published on 4 December 2012

Expression of a synthetic human interferon-alpha 1 gene with modified nucleotide sequence in mammalian cells

scientific article published in January 1986

Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection

scientific article published on July 1996

Focus on RNA polymerase II

scientific article published on 15 February 2002

Functional 5' UTR motif discovery with LESMoN: Local Enrichment of Sequence Motifs in biological Networks

scientific article

Functional dissection of the catalytic mechanism of mammalian RNA polymerase II.

scientific article

Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression

scientific article published on 10 April 2006

Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription

scientific article

High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes

scientific article published on 18 May 2009

How do our cells build their protein interactome?

scientific article published in Nature Communications

Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes

scientific article

Identification of three mammalian proteins that bind to the yeast TATA box protein TFIID.

scientific article

In vitro synthesis of the active tissue inhibitor of metalloproteinases encoded by a complementary DNA from virus-infected murine fibroblasts.

scholarly article

Increased subcutaneous adipose tissue expression of genes involved in glycerolipid-fatty acid cycling in obese insulin-resistant versus -sensitive individuals

scientific article

Inhibitors of Multisubunit RNA Polymerases as Tools to Study Transcriptional Mechanisms in Prokaryotes and Eukaryotes

article

Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome

scientific article published on 22 June 2004

Interaction of RNA Polymerase II Fork Loop 2 with Downstream Non-template DNA Regulates Transcription Elongation ⬇️

scientific article published on July 5, 2011

Interactions of a DNA-bound transcriptional activator with the TBP-TFIIA-TFIIB-promoter quaternary complex

scientific article published on 21 January 2003

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein

scientific article published on 22 July 2021

Introduction for the Special Issue of METHODS on Detection and quantification of proteins in clinical samples by mass spectrometry

scientific article published on 01 June 2015

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

scientific article

Leukodystrophy-associated mutations down-regulate the RNA polymerase III transcript and important regulatory RNA

scientific article published on 21 March 2019

Localization of subunits of transcription factors IIE and IIF immediately upstream of the transcriptional initiation site of the adenovirus major late promoter

scientific article

Mapping the Disease Protein Interactome: Toward a Molecular Medicine GPS to Accelerate Drug and Biomarker Discovery ⬇️

scientific article published on November 15, 2010

Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking

scientific article

Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.

scientific article published on 16 October 2013

Modeling contaminants in AP-MS/MS experiments

scientific article published on 31 December 2010

Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase ⬇️

scientific article published on June 7, 2012

New insights into the biogenesis of nuclear RNA polymerases?

scientific article published in April 2010

Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2

scientific article published on 30 May 2013

Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors

scientific article published on 23 February 2004

PReMod: a database of genome-wide mammalian cis-regulatory module predictions

scientific article published on 5 December 2006

Photo-cross-linking of a purified preinitiation complex reveals central roles for the RNA polymerase II mobile clamp and TFIIE in initiation mechanisms.

scientific article published on February 2004

Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics

scientific article published on 3 April 2018

Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene

scientific article published on August 1988

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein

scientific article published on 31 May 2017

RAP74 induces promoter contacts by RNA polymerase II upstream and downstream of a DNA bend centered on the TATA box.

scientific article published on July 1997

RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits

scientific article

Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum

scientific article published on 08 January 2013

Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.

scientific article published on 7 July 2015

Recombinant TBP, transcription factor IIB, and RAP30 are sufficient for promoter recognition by mammalian RNA polymerase II ⬇️

scientific article published on May 15, 1992

Regulation of interferon gene expression: mechanism of action of the If-1 locus

scientific article published on April 1988

Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code ⬇️

scientific article published on February 28, 2013

Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease

article

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)

scientific article published on 05 September 2019

Site-directed mutagenesis, purification and assay of Saccharomyces cerevisiae RNA polymerase II.

scientific article published on 28 June 2009

Site-specific protein-DNA photocross-linking of purified complexes: topology of the RNA polymerase II transcription initiation complex

scientific article published on January 2003

Steps towards a repertoire of comprehensive maps of human protein interaction networks: the Human Proteotheque Initiative (HuPI)

scientific article published on April 2008

Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II.

scientific article

Structural perspective on mutations affecting the function of multisubunit RNA polymerases

scientific article

Structure and function of murine TIMP gene

scientific article published on January 1, 1992

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

scientific article

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

scientific article

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation

scientific article published in December 2017

The RPB2 Flap Loop of Human RNA Polymerase II Is Dispensable for Transcription Initiation and Elongation ⬇️

scientific article published on June 13, 2011

The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II.

scientific article

The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis.

scientific article published on 20 June 2019

The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II

scientific article published on 20 September 2010

Topological localization of the carboxyl-terminal domain of RNA polymerase II in the initiation complex

scientific article published on July 1999

Topological localization of the human transcription factors IIA, IIB, TATA box-binding protein, and RNA polymerase II-associated protein 30 on a class II promoter

scientific article published in August 1994

Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

scientific article published on 2 December 2010

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

scientific article

Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome

scientific article published on 25 November 2019

Use of site-specific protein-DNA photocrosslinking of purified complexes to analyze the topology of the RNA polymerase II transcription initiation complex

scientific article published on January 2009

Use of site-specific protein-DNA photocrosslinking to analyze the molecular organization of the RNA polymerase II initiation complex

scientific article published on January 2001

Wrapping of promoter DNA around the RNA polymerase II initiation complex induced by TFIIF.

scientific article published on September 1998

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