List of works - Alexander Dietrich

A (+)-larixol congener with high affinity and subtype selectivity towards TRPC6.

scientific article published on 9 March 2018

A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy

scientific article published on 01 May 2021

A role for brain-derived neurotrophic factor in B cell development

scientific article published on 9 April 2005

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.

scientific article published on 31 January 2012

Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain.

scholarly article

Another TRP to Endothelial Dysfunction

Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels

scientific article published on 27 June 2013

Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice

scientific journal article

Caspase-11 controls interleukin-1β release through degradation of TRPC1.

scientific article

Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells.

scientific article published on 13 July 2006

Chemosensory TRP channels in the respiratory tract: role in toxic lung injury and potential as "sweet spots" for targeted therapies

scientific article published on January 2013

Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension.

scientific article

Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

scholarly article

Defective diacylglycerol-induced Ca2+entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets

article

Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.

scientific article published on 21 June 2009

Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.

scientific article published on 4 February 2011

Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.

scientific article published in November 2002

Evidence for a supportive role of classical transient receptor potential 6 (TRPC6) in the exploration behavior of mice.

scientific article

Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.

scientific article

Highly homologous loci on the X and Y chromosomes are hot-spots for ectopic recombinations leading to XX maleness.

scientific article published in July 1994

In vivo TRPC functions in the cardiopulmonary vasculature.

scientific article published on 11 April 2007

Increased vascular smooth muscle contractility in TRPC6-/- mice

scientific article

Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation

scientific article published on 5 May 2016

Loss of classical transient receptor potential 6 channel reduces allergic airway response.

scientific article published on 9 July 2008

Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6.

scientific article published in January 2012

Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease

scientific article published on 01 February 2019

N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity.

scientific article published on 11 September 2003

NADPH oxidases-do they play a role in TRPC regulation under hypoxia?

scientific article published on October 2015

Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.

scientific article

Orai1-induced store-operated Ca2+entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets

scientific article published on 01 April 2014

Pathways of Ca²⁺ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle

scientific article

Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head

scientific journal article

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

scientific article

Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

scientific article published on 27 August 2010

Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel

scientific article published on 28 December 2006

Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.

scientific article

Role of TRPC1 channel in skeletal muscle function

scientific article

Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.

scientific article

Small Fluorescein Arsenical Hairpin-Based Förster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6

scientific article published on 01 July 2019

Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.

scientific article

Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1

scientific article published on 11 June 2008

Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.

scientific article

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

scientific article

TRP channels in the cardiopulmonary vasculature.

scientific article published on January 2011

TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia

scientific article published on 12 May 2018

TRPC channels in vascular cell function

scientific article published on 13 November 2009

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons

scientific article published on 18 February 2020

TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons

scientific article

TRPC3 channels are required for synaptic transmission and motor coordination

scientific article published on August 2008

TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils.

scientific article published on May 2013

TRPC6: physiological function and pathophysiological relevance

scientific article published on January 2014

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature

scientific article

The antiviral cytokines IFN-α and IFN-β modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration.

scientific article published on 5 June 2013

The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance.

scientific article

The role of classical transient receptor potential channels in the regulation of hypoxic pulmonary vasoconstriction.

scientific article published on January 2010

Transient Receptor Potential (TRP) Channels in Health and Disease

scientific article published on 04 May 2019

Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.

scientific article

Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration.

scientific article published on 6 March 2012

List of works by Alexander Dietrich

A (+)-larixol congener with high affinity and subtype selectivity towards TRPC6.

A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy

A role for brain-derived neurotrophic factor in B cell development

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.

Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain.

Another TRP to Endothelial Dysfunction

Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels

Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice

Caspase-11 controls interleukin-1β release through degradation of TRPC1.

Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells.

Chemosensory TRP channels in the respiratory tract: role in toxic lung injury and potential as "sweet spots" for targeted therapies

Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension.

Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

Defective diacylglycerol-induced Ca2+entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets

Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.

Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.

Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.

Evidence for a supportive role of classical transient receptor potential 6 (TRPC6) in the exploration behavior of mice.

Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.

Highly homologous loci on the X and Y chromosomes are hot-spots for ectopic recombinations leading to XX maleness.

In vivo TRPC functions in the cardiopulmonary vasculature.

Increased vascular smooth muscle contractility in TRPC6-/- mice

Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation

Loss of classical transient receptor potential 6 channel reduces allergic airway response.

Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6.

Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease

N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity.

NADPH oxidases-do they play a role in TRPC regulation under hypoxia?

Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.

Orai1-induced store-operated Ca2+entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets

Pathways of Ca²⁺ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle

Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel

Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.

Role of TRPC1 channel in skeletal muscle function

Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.

Small Fluorescein Arsenical Hairpin-Based Förster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6

Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.

Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1

Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

TRP channels in the cardiopulmonary vasculature.

TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia

TRPC channels in vascular cell function

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons

TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons

TRPC3 channels are required for synaptic transmission and motor coordination

TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils.

TRPC6: physiological function and pathophysiological relevance

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature

The antiviral cytokines IFN-α and IFN-β modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration.

The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance.

The role of classical transient receptor potential channels in the regulation of hypoxic pulmonary vasoconstriction.

Transient Receptor Potential (TRP) Channels in Health and Disease

Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.

Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration.