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List of works by Benjamin Cravatt

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

scientific article published on 21 December 2017

(P2) Activity-Based Proteomics–Applications for Enzyme and Inhibitor Discovery

(−)‐FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase‐1 ⬇️

scientific article published on November 17, 2003

3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling

scientific article published on 20 March 2020

A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex

scientific article published on 11 February 2020

A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex

scientific article published in 2020

A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

scientific article

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.

scientific article published on June 2015

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

scientific article published on 01 March 2019

A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A.

scientific article published on 9 March 2017

A brain detoxifying enzyme for organophosphorus nerve poisons

scientific article

A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

scientific article published on 11 July 2016

A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

scientific article published on 18 January 2016

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

scientific article published on December 2013

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

scientific article

A fluopol-ABPP HTS assay to identify PAD inhibitors ⬇️

scientific article published on August 25, 2010

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases

scientific article published on 13 July 2007

A masked zinger to block GPX4

scientific article published on 30 March 2020

A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

scientific article

A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis

scientific article published on April 2011

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

scientific article

A second fatty acid amide hydrolase with variable distribution among placental mammals

scientific article

A small molecule accelerates neuronal differentiation in the adult rat.

scientific article

A streamlined platform for high-content functional proteomics of primary human specimens

scientific article published in September 2005

A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors

scientific article

A suite of activity-based probes for human cytochrome P450 enzymes

scientific article published on August 2009

A tandem orthogonal proteolysis strategy for high-content chemical proteomics

scientific article published on July 2005

ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease

scientific article published on 04 May 2020

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

scientific journal article

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

scientific article published on 29 April 2021

ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system

scientific article published on 8 April 2015

ABHD4-dependent developmental anoikis safeguards the embryonic brain

scientific article published on 31 August 2020

ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice

scientific article

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

scientific article (publication date: May 2016)

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

scientific article

Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos

scientific article

Activation of the endocannabinoid system by organophosphorus nerve agents

scientific article

Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry

scientific article published on January 2009

Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer

scientific article

Activity-based labeling of matrix metalloproteinases in living vertebrate embryos

scientific article

Activity-based probes for monitoring postproline protease activity

scientific article

Activity-based probes for proteomic profiling of histone deacetylase complexes

scholarly article

Activity-based probes for the proteomic profiling of metalloproteases

scholarly article

Activity-based probes that target functional subclasses of phospholipases in proteomes

scientific article

Activity-based protein profiling for biochemical pathway discovery in cancer

scientific article

Activity-based protein profiling for the functional annotation of enzymes

scientific article published on October 2007

Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation

scientific article published on 12 April 2006

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

scientific article published in April 2003

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

scientific article

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

scientific article published on January 2008

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

scientific article

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article

Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice ⬇️

scientific article published on September 21, 2011

An Activity‐Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363 ⬇️

scientific article published on December 7, 2011

An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus

scientific article

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

scientific article

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase

scientific article

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

scientific article published in October 2006

An in vivo multiplexed small-molecule screening platform

scientific article

An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis

scientific article published on November 2009

Analytical platforms for activity-based protein profiling--exploiting the versatility of chemistry for functional proteomics

scientific article

Anandamide Externally Added to Lipid Vesicles Containing-Trapped Fatty Acid Amide Hydrolase (FAAH) Is Readily Hydrolyzed in a Sterol-Modulated Fashion ⬇️

scientific article published on January 18, 2012

Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain

scientific article published on 27 January 2008

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum

scientific article

Application of activity-based protein profiling to study enzyme function in adipocytes

scientific article published on January 2014

Architecture of cannabinoid signaling in mouse retina

scientific article

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

scientific article published on 18 May 2016

Assessing enzyme activities using stable isotope labeling and mass spectrometry

scientific article

Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors

scientific article

Assignment of endogenous substrates to enzymes by global metabolite profiling

scientific article

Assignment of protein function in the postgenomic era.

scientific article

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells

scientific article

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice

scientific article published on 16 October 2007

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

scientific article published on 24 March 2009

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

scientific article

Biomarkers of endocannabinoid system activation in severe obesity

scientific article

Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling

scientific article published on 07 August 2009

Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity

scientific article published on 27 August 2014

Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice

scientific article

Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells

scientific article published on 20 March 2020

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

scientific article

Breast cancer cell lines grown in vivo: what goes in isn't always the same as what comes out.

scientific article

Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis

scientific article published on 05 April 2011

Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo

scholarly article

Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation

scientific article

Cell-Based Ligand Discovery for the ENL YEATS Domain

scientific article published on 19 March 2020

Challenges for the 'chemical-systems' biologist

scientific article published in November 2008

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

scientific article

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism

scientific article

Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study

scientific article

Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase

scientific article published in August 2004

Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases

scientific article

ChemInform Abstract: Click Chemistry-Led Advances in High Content Functional Proteomics

scientific article published in 2008

ChemInform Abstract: Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

Chemical Proteomic Profiling of Human Methyltransferases

scientific article (publication date: 12 October 2016)

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

scientific article published on 27 September 2017

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

scientific article published on 6 December 2017

Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferases ⬇️

scientific article published on April 18, 2013

Chemical biology meets biological chemistry minireview series

scientific article (publication date: 9 April 2010)

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

scientific article

Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells

scientific article (publication date: 13 September 2016)

Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo

scientific article

Chemical strategies for activity-based proteomics

scientific article published on January 2004

Chemical strategies for functional proteomics

scientific article

Chemoproteomic profiling and discovery of protein electrophiles in human cells

scientific article published on 31 October 2016

Chemoselective probes for metabolite enrichment and profiling

scientific article published on 8 April 2007

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system ⬇️

scientific article published on August 22, 2010

Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.

scientific article published in November 2004

Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling

scientific article published on 01 April 2005

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

scientific article

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

scientific article

Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase

scientific journal article

Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide

scientific article published on 29 August 2005

Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

scientific article

Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases

scientific article

Comparative assessment of large-scale proteomic studies of apoptotic proteolysis

scientific article (publication date: 19 June 2009)

Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake

scientific article

Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition

scientific article published on 8 March 2012

Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

scientific article

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

scientific article

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system

scientific article (publication date: 9 September 2005)

Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase

scientific article published on 24 October 2016

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase

scientific article published on 28 June 2008

Covalent Modulators of the Vacuolar ATPase.

scientific article

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

scientific article

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

scientific article

DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells ⬇️

scientific article published on November 11, 2011

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase

scientific article

Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

scientific article published on 01 August 2018

Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor.

scientific article published on 12 May 2017

Design of activated serine–containing catalytic triads with atomic-level accuracy

scientific article

Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

scientific article published on 26 September 2019

Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton

scientific article published on 21 March 2019

Design, synthesis, and biological evaluation of a biyouyanagin compound library

scientific article

Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase

scientific article published on 23 January 2014

Determining target engagement in living systems ⬇️

scientific article published on April 1, 2013

Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis

scientific article published on 23 October 2013

Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure

scientific article published on 11 January 2016

Diced electrophoresis gel assay for screening enzymes with specified activities

scientific article published on 16 April 2013

Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice

scientific article

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

scientific article published on 28 November 2006

Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes

scientific article published in 2018

Discovering disease-associated enzymes by proteome reactivity profiling

scientific article published in November 2004

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes ⬇️

scientific article published on May 12, 2003

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

scientific article

Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12)

scientific article published on 05 February 2019

Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1 ⬇️

scientific article published on June 30, 2011

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)

scientific article published on 23 October 2013

Discovery metabolite profiling--forging functional connections between the proteome and metabolome

scientific article published in August 2005

Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture

scientific article published on 9 September 2016

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

scientific article

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

scientific article

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

scientific article published on 11 May 2020

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

scientific article published on March 2005

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

scientific article published in March 2005

Discovery of small-molecule enzyme activators by activity-based protein profiling

scientific article published on 08 June 2020

Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice

scientific article published on 15 June 2016

Disparate proteome reactivity profiles of carbon electrophiles

scientific article published on 18 May 2008

Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana

scientific article published on 11 January 2009

Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats

scientific article published on 9 December 2015

Dual Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Blockade Produces THC-Like Morris Water Maze Deficits in Mice ⬇️

scientific article published on January 27, 2012

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

scientific article

Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice

scientific article published on 3 January 2013

Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification

scientific article published on 3 December 2007

Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus

scientific article published on 3 August 2014

Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats

scientific article published on 12 November 2015

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

scientific article published on 17 June 2019

Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model

scientific article published on April 2016

Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis ⬇️

scientific article

Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge

scientific article published on 27 February 2015

Endocannabinoid Overload: Fig. 1 ⬇️

scientific article published on October 15, 2010

Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway

scientific article published on 3 July 2006

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

scientific article published on 20 October 2011

Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines

scientific article published in September 2006

Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus

scientific article published on 23 January 2009

Endocannabinoid regulation of amyloid-induced neuroinflammation.

scientific article published on 15 August 2015

Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex

scientific article

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling

scientific article

Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies.

scientific article published on 24 April 2015

Endogenous Molecules Stimulating N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) ⬇️

scientific article published on January 27, 2012

Enrichment tags for enhanced-resolution profiling of the polar metabolome

scientific article published on 5 December 2007

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

scientific article

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

scientific article

Enzyme inhibitor discovery by activity-based protein profiling

scientific article

Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors

scientific article published on 17 June 2013

Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice

scientific article published on 8 March 2018

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

scientific article

Evaluation of fatty acid amides in the carrageenan-induced paw edema model

scientific article

Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase

scientific journal article

Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

scientific article published on 28 October 2019

Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

scientific article published on 28 June 2008

FAAH genetic variation enhances fronto-amygdala function in mouse and human

scientific article

FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration

scientific article

Facile synthesis of borofragments and their evaluation in activity-based protein profiling

scientific article published in February 2015

Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task

scientific article

Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens

scientific article

Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain

scientific article

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

scientific article

Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

scientific article

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

scientific article

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice ⬇️

scientific article published on June 29, 2011

Fatty acid amide hydrolase deficiency limits early pregnancy events

scientific article

Fatty acid amide hydrolase determines anandamide-induced cell death in the liver

scientific article published on 17 January 2006

Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat.

scientific article published in November 2004

Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury

scientific article

Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice

scientific article

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

scientific article

Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis

scientific article published on 3 January 2006

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase ⬇️

scientific article published on February 28, 2011

Food for thought: endocannabinoid modulation of lipogenesis

scientific article

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

scientific article

Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice

scientific article

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification ⬇️

scientific article published on June 13, 2012

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

scientific article

Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes † ‡

scientific article

Functional disassociation of the central and peripheral fatty acid amide signaling systems

scientific article

Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome

scientific article published on July 2012

Functional lysine modification by an intrinsically reactive primary glycolytic metabolite

scientific article published on August 2013

Genetic deletion of monoacylglycerol lipase alters endocannabinoid‐mediated retrograde synaptic depression in the cerebellum ⬇️

scientific article published on September 12, 2011

Genetic loss of Faah compromises male fertility in mice

scientific article

Genomics and proteomics

scientific article (publication date: February 2007)

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474

scientific article published on 31 January 2019

Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in Cancer ⬇️

scientific article published on October 11, 2012

Global mapping of the topography and magnitude of proteolytic events in apoptosis

scientific article

Global profiling of dynamic protein palmitoylation

scientific article

Global profiling of lysine reactivity and ligandability in the human proteome.

scientific article published on 31 July 2017

Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte ⬇️

scientific article

Global strategies to integrate the proteome and metabolome

scientific article

Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans ⬇️

scientific article published on October 15, 2012

Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase

scientific article

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons

scientific article published on July 2015

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

scientific article

How Chemoproteomics Can Enable Drug Discovery and Development ⬇️

scientific article published on January 27, 2012

How many human proteoforms are there?

scientific article published in February 2018

Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.

scientific article

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

scientific article

Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells

scientific article published on February 2012

Identification of protein pheromones that promote aggressive behaviour

scientific article

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

scientific article

Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells

scientific article

Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei

scientific article

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

scientific article

In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies

scientific article published on 26 February 2018

In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics

scientific article

Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids

scientific article

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase ⬇️

scientific article published on May 1, 2003

Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice

scientific article published on 30 January 2006

Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice ⬇️

scientific article published on June 9, 2011

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay ⬇️

scientific article published on December 8, 2010

Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task

scientific article

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2‐arachidonoyl glycerol attenuates nausea in rats ⬇️

scientific article published on April 1, 2012

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice

scientific article published on 30 June 2017

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects

scientific article

Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice

scientific article published on 09 May 2009

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

scientific article

Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity

scientific article published on 23 January 2020

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

scientific article published on 27 January 2016

Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model

scientific article published on 2 October 2017

Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice

scientific article published on August 2016

Kinase chemical genomics--a new rule for the exceptions

scientific article published on 01 June 2005

LDL Receptor-Related Protein 1 Regulates the Abundance of Diverse Cell-Signaling Proteins in the Plasma Membrane Proteome ⬇️

scientific article published on October 28, 2010

Large-scale profiling of protein palmitoylation in mammalian cells

scientific article published on 11 January 2009

Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

scientific article

Ligands in crystal structures that aid in functional characterization ⬇️

scientific article published on September 30, 2010

Lipid metabolism in cancer

scientific article published on 3 August 2013

Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor

scientific article published on 29 August 2003

Live chemical reports from the cell surface

scientific article

Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules

scientific article

Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.

scientific article published in March 2009

Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics

scientific article published on 20 September 2017

Mapping enzyme active sites in complex proteomes

scientific article published in February 2004

Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells

scientific article

Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk

scientific article published on 24 July 2007

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

scientific article

Mechanism-based profiling of enzyme families

scientific article published on August 2006

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain ⬇️

scientific article published on April 19, 2011

Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides

scientific article

Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling

scientific article published on 9 December 2013

Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH.

scientific article published on February 2014

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action

scientific article published on 23 July 2015

Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors

scientific article (publication date: 14 December 2016)

Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

scientific article published in November 2011

Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium

scientific article

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

scientific article

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

scientific article published on 11 November 2016

Microarray platform for profiling enzyme activities in complex proteomes

scientific article published in December 2004

Molecular medicine and neurodegenerative diseases

scientific article

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer ⬇️

scientific article published on July 29, 2011

Monoacylglycerol Lipase Regulates Fever Response

scientific article published on 19 August 2015

Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice

scientific article published on 4 January 2013

Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling

scientific article

Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy

scientific article published on 14 March 2018

Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons

scientific article published on 18 September 2009

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

scientific article

Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors.

scientific article published on 24 November 2017

Multiplexed proteomic profiling of cysteine reactivity and ligandability in human T cells

scientific article published on 08 April 2021

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

scientific article

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink ⬇️

scientific article published on March 3, 2013

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

scientific article

Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum

scientific article published on 12 May 2016

Novel Inhibitors for PRMT1 Discovered by High-Throughput Screening Using Activity-Based Fluorescence Polarization ⬇️

scientific article published on April 20, 2012

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

scientific article

O-Hydroxyacetamide Carbamates as a Highly Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors ⬇️

scientific article published on October 10, 2011

Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.

scientific article published on 9 October 2017

Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes

scientific article published on 25 January 2008

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

scientific article published on March 2008

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).

scientific article

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

scientific article published on 13 August 2018

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

scientific article published on June 2016

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

scientific article published in September 2017

Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo

scientific article

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

scientific article published on 25 March 2019

Phosphatidylinositol 3,4,5-Trisphosphate Activity Probes for the Labeling and Proteomic Characterization of Protein Binding Partners ⬇️

scientific article published on November 30, 2011

Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development

scientific article published on 30 December 2020

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase

scientific article published on 6 February 2007

Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance ⬇️

scientific article published on September 27, 2011

Practical 4'-phosphopantetheine active site discovery from proteomic samples

scientific article

Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition

scientific article published on 27 April 2010

Profiling enzyme activities in vivo using click chemistry methods

scientific article published on April 2004

Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice

scientific article

Protein-reactive natural products

scientific article

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

scientific article

Proteome-wide covalent ligand discovery in native biological systems

scientific article

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa.

scientific article

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

scientific article published on 10 February 2013

Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria

scientific article published on March 2013

Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition

scientific article published on 23 May 2013

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

scientific article

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

scientific article published on 26 March 2006

Proteomics--advances, applications and the challenges that remain

scientific article published on 01 December 2002

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

scientific article

Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites

scientific article

Quantitative reactivity profiling predicts functional cysteines in proteomes

scientific article

RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia

scientific article

Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study

scientific article published on 08 March 2008

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

scientific article

Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9

scientific article published on 20 August 2012

Rational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residues

scientific article

Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis

scientific article published on 30 August 2018

Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA.

scientific article published on December 2003

Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.

scientific article published on 14 July 2004

Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

scientific article published on 3 July 2017

Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase

scientific article

Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor

scientific article published on 27 March 2008

Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone

scientific article published on 04 February 2014

Repeated Low-Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains Cannabinoid Receptor Type 1–Mediated Antinociceptive and Gastroprotective Effects ⬇️

scientific article published on February 14, 2013

Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli ⬇️

scientific article published on October 31, 2011

Retrograde endocannabinoid signaling in the cerebellar cortex

scientific article published on January 2006

Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics ⬇️

scientific article published on March 23, 2011

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

scientific article

Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain

scientific article published on 07 August 2016

Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase

scientific article

Role of the satiety factor oleoylethanolamide in alcoholism

scientific article

Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.

scientific article published on 26 May 2018

Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases

scientific article published on 25 June 2015

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

scientific article

Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo

article

Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.

scientific article published on 18 July 2011

Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival

scientific article

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)

scientific article published on 2 December 2012

Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice

scientific article published on 11 March 2015

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

scientific article

Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions

scientific article published on September 2006

Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation

scientific article published on 02 December 2013

Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Δ9-tetrahydrocannabinol in mice

scientific article published on 24 February 2015

Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate ⬇️

scientific article published on May 19, 2013

Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa

scientific article

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

scientific article

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex

scientific article published on 6 October 2017

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

scientific article

Structural commonalities among integral membrane enzymes

scientific article published on June 2004

Structure and function of fatty acid amide hydrolase

scientific article

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase

scientific article published on 9 June 2007

Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids

scientific article published in August 2006

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

scientific article

Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes

scientific article published on 01 November 2006

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

scientific article

Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala

scientific article

Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception

scientific article published on 31 December 2008

Synthesis and Sulfur Electrophilicity of theNupharThiaspirane Pharmacophore

scientific article

Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes

scientific article

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes

scientific article

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

scientific article published on 2 October 2005

Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis

scientific article

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

scientific article

Tetrahedron young investigator award 2008.

scientific article published on November 2008

The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain

scientific article published on 13 February 2020

The Endocannabinoid System: From Basic Research toTranslational Opportunity.

scientific article published on 16 May 2012

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease ⬇️

scientific article published on June 23, 2011

The Proteome-Wide Potential for Reversible Covalency at Cysteine

scientific article published on 05 July 2019

The RON‐receptor regulates pancreatic cancer cell migration through phosphorylation‐dependent breakdown of the hemidesmosome ⬇️

scientific article published on March 8, 2012

The Scripps Molecular Screening Center and Translational Research Institute

scientific article published on 25 January 2019

The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model

scientific article

The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase

scientific article published on 17 September 2018

The biological impact of mass-spectrometry-based proteomics

scientific article published on December 2007

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine

scientific article published on 30 June 2009

The development and application of methods for activity-based protein profiling

scientific article published on February 2004

The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways

scientific article (publication date: 21 May 2009)

The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice

scientific article published on 24 November 2016

The endogenous cannabinoid system and its role in nociceptive behavior

scientific article

The endogenous cannabinoid system protects against colonic inflammation

scientific article published on April 2004

The enzymatic inactivation of the fatty acid amide class of signaling lipids

scientific article

The expanding role of mass spectrometry in metabolite profiling and characterization

scientific article

The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice ⬇️

scientific article published on April 1, 2012

The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice

scientific article published on August 2010

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

scientific journal article

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

scientific article published on 28 June 2012

The pharmacological landscape and therapeutic potential of serine hydrolases ⬇️

scientific article published on January 3, 2012

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

scientific article published in December 2004

The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases

scientific article

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

scientific article

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH) ⬇️

scientific article published on May 8, 2012

ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue

scientific article

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

scientific article

Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes

scientific article (publication date: October 2002)

Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects

scientific article published on 02 October 2013

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

scientific article

Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice

scientific article

β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors

scientific article published on June 2012

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