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List of works by Heather C Whalley

248. Neuroimaging Biomarkers Predicting Disorder in Those at High Familial Risk of Schizophrenia or Bipolar Disorder

393. Reduced Inhibitory Influence of Insula Cortex upon the Limbic System in Individuals at High Familial Risk of Mood Disorder with Depression

article published in 2017

42. Epigenetic Age Acceleration in Depression

437. Modeling Schizophrenia in Human Induced Pluripotent Stem Cells (hiPSCs): Phenotypic Differences in Patients with Mutations in NDE1

783. Neurobiological Findings from a Ten-Year Prospective Longitudinal Study of Mood Disorder

A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function.

scientific article published in May 2009

A MRI study of ocular hypertelorism in individuals at high risk of developing schizophrenia

scientific article published on 01 May 2001

A common neural system mediating two different forms of social judgement.

scientific article published on 8 October 2009

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

scientific article published on 17 July 2013

A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.

scientific article published on 4 December 2012

A meta-analysis of genome-wide association studies of epigenetic age acceleration

scientific article published on 18 November 2019

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

scientific article

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

scientific article published on 08 May 2020

A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders

scientific article

A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia

scientific article published on 19 April 2006

Aberrant structural covariance networks in youth at high familial risk for mood disorder

scientific article published on 23 November 2019

Abnormal cortical folding in high-risk individuals: a predictor of the development of schizophrenia?

article

Accuracy and reproducibility of simple cross-sectional linear and area measurements of brain structures and their comparison with volume measurements

scientific article published in April 2001

Age-related functional brain changes in FMR1 premutation carriers.

scientific article published on 9 December 2017

Altered amygdala connectivity within the social brain in schizophrenia

scientific article published on 12 July 2013

An automated machine learning approach to predict brain age from cortical anatomical measures

scientific article published on 16 May 2020

An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!

scientific article

Antioxidant and B vitamin intake in relation to cognitive function in later life in the Lothian Birth Cohort 1936

article

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

scholarly article by Miruna C. Barbu et al published July 2018 in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

scientific article

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

Association of white matter integrity with genetic variation in an exonic DISC1 SNP

scientific article published on 01 March 2011

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

scholarly article published 14 March 2018

Associations between vascular risk factors and brain MRI indices in UK Biobank

scientific article published on 01 July 2019

Associations between vascular risk factors and brain MRI indices in UK Biobank: Supplementary Material

Automated classification of depression from structural brain measures across two independent community-based cohorts

scientific article published on 19 June 2020

Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function

scientific article published on 10 August 2016

Between- and within-scanner variability in the CaliBrain study n-back cognitive task

scientific article published on 28 September 2010

Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression

scientific article published on 08 May 2020

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

article

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

scientific article published on 18 May 2020

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

scientific article published on 28 May 2020

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

scientific article published on 08 December 2020

Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia

scientific article published in May 2001

Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed

scientific article

Central and non-central networks, cognition, clinical symptoms, and polygenic risk scores in schizophrenia

scientific article published on 7 September 2017

Childhood adversity and cortical thickness and surface area in a population at familial high risk of schizophrenia

scientific article

Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia.

scientific article

Cognitive biases predict symptoms of depression, anxiety and wellbeing above and beyond neuroticism in adolescence

article

Cognitive functioning and lifetime major depressive disorder in UK Biobank

scientific article published on 21 February 2020

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

scientific article published in 2019

Computational neuropsychiatry - schizophrenia as a cognitive brain network disorder

scientific article

Connecting the brain and new drug targets for schizophrenia.

scientific article published in January 2009

Correction: Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank

scientific article published on 14 July 2022

Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

scientific article published on 01 December 2019

Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia

scientific article

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

article

Cortical Surface Area Differentiates Familial High Risk Individuals Who Go on to Develop Schizophrenia.

scientific article published on 7 February 2015

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

scientific article

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

scientific article

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

scientific article published on 2 May 2017

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years ⬇️

journal article from 'Human Brain Mapping' published in 2022

Cortical thickness in first-episode schizophrenia patients and individuals at high familial risk: a cross-sectional comparison

scientific article published on 10 October 2013

DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging

scientific article published on 7 December 2021

DNA methylation age acceleration and risk factors for Alzheimer's disease

scholarly article published 8 March 2018

DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder

scientific article

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

scientific article published on 31 March 2022

Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study

scientific article published on 15 July 2016

Deficits in facial, body movement and vocal emotional processing in autism spectrum disorders.

scientific article published on 27 January 2010

Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder

scientific article published on 28 February 2018

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts.

scientific article

Dissociation of Brain Activation in Autism and Schizotypal Personality Disorder During Social Judgments

scientific article published in October 2017

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

scientific article published on 29 May 2020

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies

scientific article published on 16 September 2021

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies

scientific article published on 31 December 2021

Effect of variation in diacylglycerol kinase η (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder

scientific article published on 2 November 2011

Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity

scientific article

Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia

scientific article published on 15 February 2012

Effects of environmental risks and polygenic loading for schizophrenia on cortical thickness

scientific article

Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion

scientific article published on 18 February 2011

Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia

scientific article published on 18 October 2010

Empirical comparison of maximal voxel and non-isotropic adjusted cluster extent results in a voxel-based morphometry study of comorbid learning disability with schizophrenia

article

Epigenetic prediction of complex traits and death

article by Daniel L McCartney et al published 27 September 2018 in Genome Biology

Epigenetic prediction of complex traits and death

Epigenetic prediction of major depressive disorder

scientific article published on 10 June 2020

Epigenetic signatures of starting and stopping smoking

scientific article published on 30 October 2018

Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target

scientific article published on 02 December 2021

Event-related fMRI of word classification and successful word recognition in subjects at genetically enhanced risk of schizophrenia

scientific article published on October 2006

Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

scientific article published on 04 February 2020

Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task

scientific article published on 23 July 2009

Functional disconnectivity in subjects at high genetic risk of schizophrenia

scientific article

Functional imaging as a predictor of schizophrenia

scientific article

Functional imaging of emotional memory in bipolar disorder and schizophrenia

scientific article published in December 2009

Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task

scientific article published on 13 August 2010

Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure

scientific article published in January 2006

Genetic liability, brain structure and symptoms of schizophrenia

Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals.

scientific article published on 10 October 2011

Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia.

scientific article published on 18 April 2008

Genome-wide association studies establish that human intelligence is highly heritable and polygenic

scientific article

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

scientific article published on 04 February 2019

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.: Supplementary Information

Greater male than female variability in regional brain structure across the lifespan

scientific article published on 12 October 2020

Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank)

scientific article published on 07 January 2021

Grey matter changes can improve the prediction of schizophrenia in subjects at high risk

scientific article

Grey matter changes over time in high risk subjects developing schizophrenia

scientific article published in May 2005

Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland

scientific article published on 12 October 2021

Hippocampal, amygdala and nucleus accumbens volume in first-episode schizophrenia patients and individuals at high familial risk: A cross-sectional comparison.

scientific article published on 10 April 2015

Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins.

scientific article published on 07 January 2014

Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms.

scientific article published on 4 March 2008

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

scientific article published on 29 March 2019

Imaging conditioned fear circuitry using awake rodent fMRI

scientific article

Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank

scientific article published on 22 April 2019

Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder

scientific article

Impact of cannabis use on thalamic volume in people at familial high risk of schizophrenia

scientific article published on 8 September 2011

Impact of cross-disorder polygenic risk on frontal brain activation with specific effect of schizophrenia risk.

scientific article

In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group

scientific article published on 19 October 2020

Information processing speed mediates the relationship between white matter and general intelligence in schizophrenia

scientific article

Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1

scientific article published on 15 December 2021

Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

scientific article published on 07 October 2020

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease

scientific article published on 21 June 2018

Longitudinal changes in hippocampal volume in the Edinburgh High Risk Study of Schizophrenia.

scientific article published in December 2014

Longitudinal differences in white matter integrity in youth at high familial risk for bipolar disorder

scientific article

Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

scientific article published on 17 December 2019

Lower effective connectivity between amygdala and parietal regions in response to fearful faces in schizophrenia

scientific article published on 22 October 2011

Magnetic resonance imaging of brain in people at high risk of developing schizophrenia

scientific article published in January 1999

Medial temporal lobe function during emotional memory in early Alzheimer's disease, mild cognitive impairment and healthy ageing: an fMRI study

scientific article

Methodological issues in volumetric magnetic resonance imaging of the brain in the Edinburgh High Risk Project.

scientific article

Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system

scientific article published on 08 December 2021

Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia

scientific article published in December 2010

Modelling a Genetic Risk for Schizophrenia in Human Induced Pluripotent Stem Cells (Ipscs): Phenotypic Differences in Patients with Mutations in Nde1

Modulation of hippocampal activation by genetic variation in the GRIK4 gene.

scientific article published in May 2009

Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: preliminary findings from a 6-year follow-up study

scientific article published on 3 December 2015

Neural correlates of enhanced genetic risk for schizophrenia

scientific article

Neurocognition in individuals at high familial risk of mood disorders with or without subsequent onset of depression

scientific article published on 20 July 2015

Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia

scientific article published on 01 February 2003

Overactivation of fear systems to neutral faces in schizophrenia

scientific article published on 4 March 2008

Parcellating the temporal lobes from magnetic resonance images using generic software in subjects at high risk of developing schizophrenia

scientific article published in August 2006

Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people.

scientific article published in May 2003

Polygenic risk and white matter integrity in individuals at high risk of mood disorder

scientific article

Polygenic risk for schizophrenia, transition and cortical gyrification: a high-risk study.

scientific article published on 25 October 2017

Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

scientific article published on 01 September 2018

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.

scientific article

Predicting sex, age, general cognition and mental health with machine learning on brain structural connectomes

scientific article published in April 2023

Prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging

scientific article

Prefrontal Function and Activation in Bipolar Disorder and Schizophrenia

scientific article published on 15 January 2008

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.

scientific article published on 26 May 2017

Preliminary assessment of pre-morbid DNA methylation in individuals at high genetic risk of mood disorders

scientific article published on 21 July 2016

Progress in imaging the effects of psychosis susceptibility gene variants

scientific article published on January 2013

Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression

scientific article published on 31 December 2015

Prospective longitudinal voxel-based morphometry study of major depressive disorder in young individuals at high familial risk.

scientific article

Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data

scientific article

Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank

scientific article published on 27 April 2020

Range of motion of the metacarpophalangeal joint in rheumatoid patients, with and without a flexible joint replacement prosthesis, compared with normal subjects

scientific article published on 20 January 2012

Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations

scientific article

Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression

scientific article published on 28 September 2022

Relationship between gyrification and functional connectivity of the prefrontal cortex in subjects at high genetic risk of schizophrenia

scientific article published in January 2012

Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.

scientific article published on 2 October 2006

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

scientific article published on 22 November 2018

Response to Dr Fried & Dr Kievit, and Dr Malhi et al

scientific article published on 23 February 2016

Resting-State Connectivity and Its Association With Cognitive Performance, Educational Attainment, and Household Income in the UK Biobank

scientific article published on 04 July 2018

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Review of functional magnetic resonance imaging studies comparing bipolar disorder and schizophrenia

scientific article

S125. Different Definitions Reflect Neurobiologically Distinct Subtypes of Depression

S130. Dissecting the Neuroimaging Phenotype of Major Depressive Disorder Based on Genetic Loading for Schizophrenia

scholarly article by Heather C Whalley et al published May 2018 in Biological Psychiatry

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

article

Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants

article

Social cognition, the male brain and the autism spectrum.

scientific article

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

scientific article published on 18 July 2019

Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study

Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry

scientific article published in October 2002

Structural magnetic resonance imaging markers of susceptibility and transition to schizophrenia: a review of familial and clinical high risk population studies.

scientific article

Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank

scientific article published on 13 April 2022

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

scientific article

Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

scientific article

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

scientific article

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

scholarly article published 22 August 2016

Subcortical volumetric abnormalities in bipolar disorder

scientific article

Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms.

scientific article published in August 2002

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

scientific article

The Neurobiology of Personal Control During Reward Learning and Its Relationship to Mood

scientific article published on 09 October 2018

The Stratification Of Major Depressive Disorder Into Genetic Subgroups

scholarly article published 5 May 2017

The application of nonlinear Dynamic Causal Modelling for fMRI in subjects at high genetic risk of schizophrenia

scientific article

The directional effects of passive eye movement on the directional visual responses of single units in the pigeon optic tectum.

scientific article

The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls--a randomized placebo-controlled, double-blind fMRI study

scientific article

The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia

article

The impact of substance use on brain structure in people at high risk of developing schizophrenia

scientific article

The neural basis of familial risk and temperamental variation in individuals at high risk of bipolar disorder

scientific article

The neurobiological underpinnings of risk and conversion in relatives of patients with schizophrenia

scientific article

The role of brain-derived neurotrophic factor in learned fear processing: an awake rat fMRI study.

scientific article published on 20 November 2015

The role of neuroticism in self-harm and suicidal ideation: results from two UK population-based cohorts

scientific article published on 23 May 2019

Virtual Ontogeny of Cortical Growth Preceding Mental Illness

scientific article published in 2022

Voxel based morphometry of grey matter reductions in schizophrenia and the impact of generic versus specific normalisation templates

article by Dominic Job et al published June 2001 in NeuroImage

Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods

scientific article published in May 2004

Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia

scientific article

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

scientific article published on 29 July 2020

White Matter Microstructure and Its Relation to Longitudinal Measures of Depressive Symptoms in Mid- and Late Life

scientific article published on 22 June 2019

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

scientific article published on 30 August 2019

White matter integrity and cognition in childhood and old age.

scientific article published in February 2006

White matter integrity and its association with affective and interpersonal symptoms in borderline personality disorder

scientific article

White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder

scientific article

Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

scientific article published on 21 August 2019

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.

scientific article

fMRI correlates of state and trait effects in subjects at genetically enhanced risk of schizophrenia

scientific article published on 28 January 2004

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