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List of works by Yin Cheong Wong

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

scientific article published on 18 November 2016

Alterations in the CNS effects of anti-epileptic drugs by Chinese herbal medicines.

scientific article published on 13 December 2013

Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice.

scientific article published on 20 April 2017

Comment on uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids: applicability of UV spectrum shifts in identification of glucuronidation position in flavones and flavonols

scientific article published on 19 April 2012

Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies

scientific article

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat.

scientific article published on 26 October 2017

Development, characterization and application of in situ gel systems for intranasal delivery of tacrine

scientific article published on 05 April 2014

Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling

article

Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats

scientific article published on 14 May 2015

Identification and disposition of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo.

scientific article

Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease

scientific article published on 30 June 2018

Intranasal delivery--modification of drug metabolism and brain disposition

scientific article

Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.

scientific article published on 22 September 2011

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

scientific article

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients

scientific article

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics

scientific article published on 21 September 2017

Pharmacokinetic comparison between the long-term anesthetized, short-term anesthetized and conscious rat models in nasal drug delivery.

scientific article published on 20 February 2014

Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

scientific article published on 24 January 2019

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model

scientific article published on 11 September 2017

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

scientific article

Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions ⬇️

scientific article published on 08 May 2012

Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling

scientific article published on 26 October 2016

Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases.

scientific article

Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

scientific article published on 30 April 2020

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