List of works by Kensuke Osada

A synthetic block copolymer regulates S1 nuclease fragmentation of supercoiled plasmid DNA.

scientific article published in June 2005

A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle

scientific article published on 01 April 2015

Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation

scientific article published on 03 August 2012

Block Copolymer Micelles in Nanomedicine Applications

scientific article published on 29 June 2018

Block Copolymer Micellization as a Protection Strategy for DNA Origami.

scientific article published on 15 March 2017

Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor.

scientific article

Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery

scientific article published on 04 July 2019

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.

scientific article published on January 2009

Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines

scientific article published on 24 August 2011

Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(l-lysine) block copolymers as systemic gene delivery carrier

scientific article published on 20 February 2017

Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination.

scientific article

Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: a physiologically available oxygen carrier

scientific article published in January 2007

Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles

scientific article published on 10 October 2011

Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties.

scientific article published in September 2010

Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths.

scientific article published on 10 December 2015

Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model.

scientific article published on 27 March 2015

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

scientific article published on 17 October 2017

Happy Birthday Kataoka-sensei!

scientific article published on 01 January 2017

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

scientific article

In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle

scientific article

In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

scientific article published on 24 April 2019

Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection

scientific article published on 17 January 2019

Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers.

scientific article published on 14 January 2016

Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models

scientific article

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface.

scientific article published on 7 April 2017

NanoPARCEL: a method for controlling cellular behavior with external light

scientific article published on 16 July 2012

Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.

scientific article published on 8 April 2014

Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.

scientific article published on 11 May 2012

Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression.

scientific article

Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection

article

Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration.

scientific article published on 30 November 2017

Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting

scientific article

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

scientific article published on 6 October 2010

Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability

scientific article published on 05 April 2019

Rod-to-Globule Transition of pDNA/PEG-Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness.

scientific article published in October 2015

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size, Shape, and Function of Core Cross-Linked Nanostructures.

scientific article published on 23 May 2017

Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble macromolecules

scientific article

Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer

scientific article published on 31 October 2019

Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes

scientific article published on 19 July 2020

Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

scientific article published on 31 December 2015

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

scientific article published on 15 January 2014

Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection.

scientific article

Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery

scientific article published on 23 April 2015

Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation

scientific article published on 20 September 2017

Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer

scientific article published on 2 April 2014

Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression.

scientific article published on 30 July 2015

Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines

scientific article published on 26 June 2020

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