List of works - Peter J Rutledge

(2S,4S)-3-Benzoyl-4-benzyl-2-tert-but-yl-1,3-oxazolidin-5-one

scientific article published on 23 August 2012

A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event ⬇️

scientific article published on 09 January 2013

A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation

scientific article

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase

scientific article

A direct method for the N-tetraalkylation of azamacrocycles

scientific article published on 18 November 2016

Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase

scientific article published on September 2004

Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.

scientific article

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

scientific article published on 07 October 2019

Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid.

scientific article published on 12 December 2014

Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake

scientific article published on 6 August 2010

Chemical sensors that incorporate click-derived triazoles

scientific article published on 04 March 2011

Combined "dual" absorption and fluorescence smartphone spectrometers

scientific article

Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin ⬇️

scientific article published on 17 June 2020

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

scientific article

Correction: Metal complexes as a promising source for new antibiotics

scientific article published on 16 April 2020

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase

scientific article

Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?

scientific article published on 19 December 2016

Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site

scientific article published on 4 February 2010

Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond ⬇️

scientific article published on January 1, 2012

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

scientific article published on 29 June 2015

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

scientific article published on 12 December 2018

Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids

scientific article

Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates

scientific article

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

scientific article published on 12 June 2013

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

scientific article

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight

scientific article

Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso-ene mechanism

scientific article published on 11 December 2015

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms

scientific article

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

scientific article

Metal complexes as a promising source for new antibiotics

scientific article published on 12 February 2020

Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands

scientific article

Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis ⬇️

scientific article published on 05 November 2019

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

scientific article published on 18 August 2014

Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis

scientific article published on 23 May 2016

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal

scientific article

Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing.

scientific article published on 25 January 2017

Structural studies on the reaction cycle of isopenicillin N synthase

doctoral thesis by Peter Jonathan Rutledge

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue

scientific article

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

scientific article (publication date: 15 June 2003)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine

scientific article published in May 2005

Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4.

scientific article

Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions

scientific article published on 03 August 2016

Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid.

scientific article

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

scientific article published on 12 July 2017

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase

scientific article

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site

scientific article

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue

scientific article

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron

scientific article

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography

scientific article

The properties and performance of a pH-responsive functionalised nanoparticle

scientific article published in January 2014

Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter

scientific article

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase

scientific article published in February 2006

tert-Butyl-dimethyl-silanol hemihydrate

scientific article published on 30 May 2008

List of works by Peter J Rutledge

(2S,4S)-3-Benzoyl-4-benzyl-2-tert-but-yl-1,3-oxazolidin-5-one

A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event ⬇️

A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase

A direct method for the N-tetraalkylation of azamacrocycles

Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase

Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid.

Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake

Chemical sensors that incorporate click-derived triazoles

Combined "dual" absorption and fluorescence smartphone spectrometers

Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin ⬇️

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

Correction: Metal complexes as a promising source for new antibiotics

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase

Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?

Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site

Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond ⬇️

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids

Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight

Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso-ene mechanism

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

Metal complexes as a promising source for new antibiotics

Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands

Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis ⬇️

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal

Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing.

Structural studies on the reaction cycle of isopenicillin N synthase

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine

Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4.

Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions

Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid.

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography

The properties and performance of a pH-responsive functionalised nanoparticle

Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase

tert-Butyl-dimethyl-silanol hemihydrate