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List of works by Darren Freed

2-Methoxyestradiol: A Hormonal Metabolite Modulates Stimulated T-Cells Function and proliferation.

scientific article published in July 2015

A cardioprotective preservation strategy employing ex vivo heart perfusion facilitates successful transplant of donor hearts after cardiocirculatory death.

scientific article published in July 2013

A whole blood-based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion.

scientific article published on 28 September 2014

Activation of proteases and changes in Na+-K+-ATPase subunits in hearts subjected to ischemia-reperfusion

scientific article published on 06 December 2012

Activation of proteolytic enzymes and depression of the sarcolemmal Na+/K+-ATPase in ischemia-reperfused heart may be mediated through oxidative stress

scientific article

Adipose tissue houses different subtypes of stem cells

scientific article published on 22 August 2012

Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts

scientific article published on 02 July 2009

Adipose-derived stem cells from both visceral and subcutaneous fat deposits significantly improve contractile function of infarcted rat hearts.

scientific article published on 5 January 2015

Adult presentation with a bilobed membranous ventricular septal aneurysm.

scientific article published on 17 January 2013

Assessment of donor heart viability during ex vivo heart perfusion

scientific article

Assessment of three techniques for delivering stem cells to the heart using PET and MR imaging.

scientific article published on 28 October 2013

Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage.

scientific article published on January 2014

Avoiding initial hypothermia does not improve liver graft quality in a porcine donation after circulatory death (DCD) model of normothermic perfusion

scientific article published on 06 August 2019

Can long-term ventricular assist devices be safely implanted in low-volume, non-heart transplant centres?

scientific article published on 26 September 2012

Canada's longest experience with extracorporeal membrane oxygenation as a bridge to lung transplantation: a case report.

scientific article published on January 2015

Canadian Cardiovascular Society focused position statement update on assessment of the cardiac patient for fitness to drive: fitness following left ventricular assist device implantation

scientific article published on 17 February 2012

Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts

scientific article published on 01 June 2010

Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing.

scientific article published on December 2003

Clearance of transaminases during normothermic ex situ liver perfusion

scientific article published on 24 April 2019

Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs

scientific article published on 13 November 2020

Collateral circulation formation determines the characteristic profiles of contrast-enhanced MRI in the infarcted myocardium of pigs.

scientific article

Death in low-risk cardiac surgery: the failure to achieve a satisfactory cardiac outcome (FIASCO) study.

scientific article published on 14 July 2009

Differential MR delayed enhancement patterns of chronic myocardial infarction between extracellular and intravascular contrast media

scientific article

Donor heart preservation: straight up, or on the rocks?

scientific article published on 14 April 2015

Dynamic compression of the left main coronary artery by the left atrium.

scientific article published in August 2009

Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart.

scientific article

Endovascular stenting for treatment of a left internal mammary artery pseudoaneurysm following redo‐sternotomy: A case report ⬇️

scientific article published on March 27, 2013

Ex vivo perfusion of the swine heart as a method for pre-transplant assessment.

scientific article published on 13 June 2012

Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada

article

Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series

scientific article published on 8 April 2015

FIASCO II failure to achieve a satisfactory cardiac outcome study: the elimination of system errors.

scientific article published on 16 April 2013

Functional mitral regurgitation: current understanding and approach to management.

scientific article

Growth and positioning of adipose-derived stem cells in microfluidic devices

scientific article published in November 2012

Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs

scientific article published on 12 July 2011

Hibernating myocardium: pathophysiology, diagnosis, and treatment.

scientific article published on April 2009

High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling

scientific article

Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts

scientific article published on 02 April 2014

Immunity and Stress Responses Are Induced During Ex Situ Heart Perfusion

scientific article published on 05 June 2020

Implications of protease activation in cardiac dysfunction and development of genetic cardiomyopathy in hamsters ⬇️

scientific article published on July 11, 2012

Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways ⬇️

scientific article published on November 1, 2003

Influenza Myocarditis and Myositis: Case Presentation and Review of the Literature ⬇️

scientific article published on June 8, 2011

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.

scientific article published in October 2017

Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well?

scientific article published in October 2006

Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?

scientific article published on 8 June 2010

K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts.

scientific article published on 14 January 2005

Laparoscopic nephroureterectomy in a patient with a left ventricular assist device

scientific article published on September 2013

Left ventricular outflow tract obstruction by a bioprosthetic mitral valve: diagnosis by cardiac computed tomography

scientific article published on 01 May 2009

Medium to long-term clinical outcome following stentless aortic valve replacement: comparison between allograft and xenograft valves

scientific article published on 31 March 2010

Minimally invasive left-heart decompression during venoarterial extracorporeal membrane oxygenation: an alternative to a percutaneous approach

scientific article published on 05 February 2010

Multicentre Canadian experience with the HeartWare ventricular assist device: concerns about adverse neurological outcomes.

scientific article published on 15 August 2014

Multimodality cardiac imaging of infective endocarditis

scientific article published in January 2015

Multimodality imaging of a cardiac pheochromocytoma.

scientific article published on 23 April 2014

Multimodality imaging of a right atrial myxoma with pulmonary embolization

scientific article published on 25 February 2012

Pathological mechanism for delayed hyperenhancement of chronic scarred myocardium in contrast agent enhanced magnetic resonance imaging

scientific article

Quantitative assessment of cardiac output and left ventricular function by noninvasive phase-contrast and cine MRI: validation study with invasive pressure-volume loop analysis in a swine model

scientific article published on 19 May 2011

Rat model of veno-arterial extracorporeal membrane oxygenation.

scientific article published on 07 February 2014

Resuscitative extracorporeal membrane oxygenation for in hospital cardiac arrest: a Canadian observational experience

scientific article

Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration

scientific article published on 13 May 2011

Short-term mechanical circulatory support for recovery from acute right ventricular failure: clinical outcomes

scientific article published on 04 March 2014

Simultaneous Salmonella spp. endocarditis and mycotic abdominal aortic aneurysm presentation: a surgical dilemma.

scientific article

Statins impair survival of primary human mesenchymal progenitor cells via mevalonate depletion, NF-κB signaling, and Bnip3.

scientific article published on 30 December 2014

Stentless aortic valve replacement in patients with bicuspid aortic valve disease: clinical outcome and aortic diameter changes during follow-up.

scientific article published on 12 March 2010

Successful ablation of idiopathic left ventricular tachycardia in an adult patient during extracorporeal membrane oxygenation treatment

scientific article published on December 2013

Successful cardiac resuscitation with extracorporeal membrane oxygenation in the setting of persistent ventricular fibrillation: a case report

scientific article

Successful repair of donation after circulatory death lungs with large pulmonary embolus using the lung organ care system for ex vivo thrombolysis and subsequent clinical transplantation

scientific article published on 01 January 2015

Successful transplantation of extended criteria lungs after prolonged ex vivo lung perfusion performed on a portable device.

scientific article published on 27 October 2014

Superparamagnetic iron oxide does not affect the viability and function of adipose-derived stem cells, and superparamagnetic iron oxide-enhanced magnetic resonance imaging identifies viable cells.

scientific article published on 26 July 2008

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

scientific article published on 26 February 2014

Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model

scientific article

The acutely occluded left main coronary artery culprit in cardiogenic shock and initial percutaneous coronary intervention: a substudy of the Manitoba "no option" left main PCI registry.

scientific article published on 22 August 2012

The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients

scientific article published on 2 March 2014

The effect of total spinal anesthesia on cardiac function in a large animal model of brain death.

scientific article published on 30 May 2012

The participation of the Na+–Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation

scientific article published on 01 November 2007

The utility of cardiac biomarkers and echocardiography for the early detection of bevacizumab- and sunitinib-mediated cardiotoxicity.

scientific article published on 19 June 2015

Total parenteral nutrition in ex vivo lung perfusion: Addressing metabolism improves both inflammation and oxygenation

scientific article published on 11 September 2019

Type A aortic dissection complicated by an aorto-right atrial fistula

scientific article published on 29 December 2014

Unanticipated intra-operative finding of pulmonary artery tumour thromboembolism during radical nephrectomy and caval thrombectomy: Case report and management.

scientific article published on May 2013

Ventricular septal defect as a result of direct trauma from mechanical mitral valve prosthesis

scientific article published on 01 March 2011

Viability and proliferation potential of adipose-derived stem cells following labeling with a positron-emitting radiotracer.

scientific article published on 5 March 2011

What are the predictors that affect the excellent long-term benefits of redo coronary artery bypass grafting?

scientific article published on 24 April 2010

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