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List of works by Patrick C Fraering

A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research

A compressible scaffold for minimally invasive delivery of large intact neuronal networks

scientific article published on September 2014

Accurate resistivity mouse brain mapping using microelectrode arrays

scientific article published on 13 April 2014

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

scientific article published in January 2013

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes

scientific article

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

scientific article

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

scientific article

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

scientific article

Detection of Alzheimer's disease amyloid-beta plaque deposition by deep brain impedance profiling

scientific article published on 16 February 2015

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

scientific article published on January 2004

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

scientific article

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

scientific article

Ferritin H gene deletion in the choroid plexus and forebrain results in hydrocephalus

article

Gene expression profiling in cells with enhanced gamma-secretase activity

scientific article

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies

scientific article published on 25 October 2012

Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae

scientific article

Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach

scientific article

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

scientific article

Identification of truncated C-terminal fragments of the Alzheimer's disease amyloid protein precursor derived from sequential proteolytic pathways

scientific article published on 05 August 2020

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

scientific article published in December 2014

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

scientific article published on 12 December 2016

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

scientific article published in October 2012

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

scientific article published on 17 March 2011

Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.

scientific article published on 17 March 2010

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

scientific article

Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.

scientific article published on 27 January 2014

Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases

scientific article

Production of active glycosylation-deficient γ-secretase complex for crystallization studies

scientific article published on 9 June 2015

Purification and characterization of the human gamma-secretase complex

scientific article

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

scientific article published on 6 November 2007

Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

scientific article published on 29 December 2016

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides

scientific article published on 7 February 2012

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

scientific article published on 19 December 2016

Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease

scientific article published on December 2007

Substrate-targeting gamma-secretase modulators

scientific article published on June 2008

The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

scientific article published in June 2017

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptides

scientific article

The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p

scientific article

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

scientific article

The glycosylphosphatidylinositol (GPI) signal sequence of human placental alkaline phosphatase is not recognized by human Gpi8p in the context of the yeast GPI anchoring machinery

scientific article published in November 2002

The lipidome associated with the γ-secretase complex is required for its integrity and activity

scientific article published in February 2016

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation

scientific article published on 3 December 2012

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

scientific article published on 17 January 2017

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

scientific article

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