List of works - Anna Bigas Salvans

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

scientific article published in November 2017

A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer.

scientific article

Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma.

scientific article

BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent

scientific article

Blood Development: Hematopoietic Stem Cell Dependence and Independence

article

Blood stem cells: from beginning to end.

scientific article

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch

scientific article published on 5 December 2014

Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer

scientific article

Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair

scientific article published on 17 June 2021

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance

scientific article published in April 2015

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer

scientific article published on January 2014

Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins.

scientific article published on September 2006

Efficient nuclear export of p65-IκBα complexes requires 14-3-3 proteins.

scientific article published in June 2016

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

scientific article published on 24 December 2012

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia.

scientific article published on April 2011

IKKα is required in the intestinal epithelial cells for tumour stemness.

scientific article published on 13 February 2018

Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.

scientific article

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

scientific article published on 5 June 2008

Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer

scientific article

Intra-Bone Marrow Transplantation Confers Superior Multilineage Engraftment of Murine Aorta-Gonad Mesonephros Cells Over Intravenous Transplantation

scientific article published on 07 January 2016

IκBα deficiency imposes a fetal phenotype to intestinal stem cells

scientific article published on 09 April 2020

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

scholarly article

Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.

scientific article published on 30 August 2013

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.

scientific article published on 10 March 2015

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

scientific article published in Nature Communications

MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny.

scientific article published on August 2013

Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals

scientific article published on 26 September 2013

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer.

scientific article published on 25 May 2017

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

scientific article published in November 2017

NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells.

scientific article

Non-conventional functions for NF-κB members: the dark side of NF-κB.

scientific article published on 30 June 2014

Notch and Stem Cells

scientific article published on 01 January 2018

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

scientific article published on 09 March 2020

Notch signal strength controls cell fate in the haemogenic endothelium

scientific article

Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides.

scientific article published on 24 August 2015

Novel functions of chromatin-bound IκBα in oncogenic transformation.

scientific article

Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma.

scientific article published on 22 February 2018

Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.

scientific article

Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression

scientific article published on May 2015

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article

Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice

scientific article published on 15 May 2013

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.

scientific article published on 27 September 2016

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

scientific article published on 31 March 2014

RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.

scientific article published in October 2010

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

scientific journal article

Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression

scientific article

Revisiting β-Catenin Signaling in T-Cell Development and T-Cell Acute Lymphoblastic Leukemia

scientific article published on 19 December 2019

Role of p27Kip1 as a transcriptional regulator.

scientific article

The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.

scientific article published on 17 March 2015

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

scientific article

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

scientific article published on March 2014

The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation

scientific article published on 05 August 2020

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis

scientific journal article

The evolution of relapse of adult T cell acute lymphoblastic leukemia

scientific article published on 23 November 2020

The multiple usages of Notch signaling in development, cell differentiation and cancer

scientific article published on 10 July 2018

The notch pathway positively regulates programmed cell death during erythroid differentiation.

scientific article published on 3 May 2007

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes

scientific article published on 19 December 2011

p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes

scientific article published on 3 February 2017

p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

scientific article published on 23 May 2022

β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.

scientific article published on 29 April 2016

List of works by Anna Bigas Salvans

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer.

Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma.

BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent

Blood Development: Hematopoietic Stem Cell Dependence and Independence

Blood stem cells: from beginning to end.

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch

Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer

Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer

Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins.

Efficient nuclear export of p65-IκBα complexes requires 14-3-3 proteins.

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia.

IKKα is required in the intestinal epithelial cells for tumour stemness.

Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer

Intra-Bone Marrow Transplantation Confers Superior Multilineage Engraftment of Murine Aorta-Gonad Mesonephros Cells Over Intravenous Transplantation

IκBα deficiency imposes a fetal phenotype to intestinal stem cells

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny.

Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer.

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells.

Non-conventional functions for NF-κB members: the dark side of NF-κB.

Notch and Stem Cells

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

Notch signal strength controls cell fate in the haemogenic endothelium

Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides.

Novel functions of chromatin-bound IκBα in oncogenic transformation.

Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma.

Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.

Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression

Revisiting β-Catenin Signaling in T-Cell Development and T-Cell Acute Lymphoblastic Leukemia

Role of p27Kip1 as a transcriptional regulator.

The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis

The evolution of relapse of adult T cell acute lymphoblastic leukemia

The multiple usages of Notch signaling in development, cell differentiation and cancer

The notch pathway positively regulates programmed cell death during erythroid differentiation.

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes

p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes

p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.