List of works - Michael R. Blackburn

A role for neural pathways in adenosine-induced bronchoconstriction.

scientific article

A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6'-dimycolate induced granulomatous response

scientific article

A role of erythrocytes in adenosine monophosphate initiation of hypometabolism in mammals

scientific article

A semiautomated framework for integrating expert knowledge into disease marker identification

scientific article published on 10 October 2013

A1 adenosine receptors mediate hypoglycemia-induced neuronal injury.

scientific article published in February 2004

A1 adenosine receptors mediate hypoxia-induced ventriculomegaly

scientific article

A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli

scientific article

A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation

scientific article

A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation

scientific article

A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge

scientific article published on 8 June 2006

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

scientific article published on 27 June 2008

Abnormal alveolar development associated with elevated adenine nucleosides

scientific article

Adenosine A2B receptor and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease

scientific article

Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance

scientific article

Adenosine and dopamine receptors coregulate photoreceptor coupling via gap junction phosphorylation in mouse retina

scientific article published on February 2013

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

scientific article published on 15 May 2019

Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease

scientific article

Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation

scientific article

Adenosine deaminase deficiency: unanticipated benefits from the study of a rare immunodeficiency

scientific article published in February 2012

Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism

scientific article

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

scientific journal article

Adenosine mediated desensitization of cAMP signaling enhances T-cell responses

scientific article

Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway

scientific article published on August 2003

Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis

scientific article

Adenosine promotes vascular barrier function in hyperoxic lung injury.

scientific article

Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement

scientific article

Adenosine receptors and inflammation

scientific article published on January 2009

Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease

scientific article published on 15 September 2009

Adenosine signaling and the regulation of chronic lung disease

scientific article published on 05 May 2009

Adenosine signaling contributes to ethanol-induced fatty liver in mice.

scientific article published on 16 February 2009

Adenosine signaling during acute and chronic disease states

scientific article

Adenosine signaling in asthma and chronic obstructive pulmonary disease

scientific article

Adenosine signaling, priapism and novel therapies

scientific article published on March 2009

Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells

scientific article published on 28 October 2011

Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

scientific article (publication date: 16 February 2010)

Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension

scientific article published on 28 September 2015

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

scientific article

Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS)

scientific article

Animal models of airway diseases

scientific article published on January 2011

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.

scientific article

Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice

scientific article

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia

scientific article published in August 2016

Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis

scientific article

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

scientific article published on 11 October 2011

Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements

scientific article

Constant darkness is a circadian metabolic signal in mammals

scientific article published in January 2006

Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice

scientific article

Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulation

scientific article published on 20 October 2008

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

scientific article published on 19 April 2013

Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension

scientific article published on 15 October 2014

Detrimental effects of adenosine signaling in sickle cell disease

scientific article published on 19 December 2010

Disease-specific gene expression profiling in multiple models of lung disease

scientific article

Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injury.

scientific article published on 13 December 2010

Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines

scientific article

Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice

scientific article

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

scientific journal article

Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity

scientific article

Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension

scientific article published on 12 April 2013

Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia

scientific article published on 23 December 2014

Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts

scientific article

Endogenous osteopontin promotes ozone-induced neutrophil recruitment to the lungs and airway hyperresponsiveness to methacholine

scientific article published on 10 May 2013

Enhanced CXCL1 production and angiogenesis in adenosine-mediated lung disease

scientific article published on 16 January 2007

Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor

scientific article published on June 2009

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

scientific article published on 24 January 2012

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

scientific article published on 07 February 2017

Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression

scientific article

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

scientific article

Excessive Penile Norepinephrine Level Underlies Impaired Erectile Function in Adenosine A1 Receptor Deficient Mice

scientific article published on 02 August 2012

Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancy

scientific article published on 19 November 2003

Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis

scientific article

Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis

scientific article

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report

scientific article published on January 2014

Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction

scientific article published on 25 July 2012

Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance

scientific article published on 13 January 2005

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues

scientific article published on 29 December 2006

High Levels of Adenosine Deaminase on Dendritic Cells Promote Autoreactive T Cell Activation and Diabetes in Nonobese Diabetic Mice

scientific article published on 18 May 2011

Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis.

scientific article

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.

scientific article

IL-6 mediates 11βHSD type 2 to effect progression of the mycobacterial cord factor trehalose 6,6'-dimycolate-induced granulomatous response

scientific article

In Vivo Transduction by Intravenous Injection of a Lentiviral Vector Expressing Human ADA into Neonatal ADA Gene Knockout Mice: A Novel Form of Enzyme Replacement Therapy for ADA Deficiency

article

Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling

scientific article

Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis

scientific article published on June 2008

Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage

scientific article

Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury

scientific article

Loss of CD73-mediated actin polymerization promotes endometrial tumor progression

scientific article published on 7 December 2015

Mechanisms of apoptosis in developing thymocytes as revealed by adenosine deaminase-deficient fetal thymic organ cultures

scientific article published on October 2003

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

scientific journal article

Modulation of ischaemic contracture in mouse hearts: a ‘supraphysiological’ response to adenosine

scientific article published on 10 November 2006

Muc5b is required for airway defence

scientific journal article

Mucin is produced by clara cells in the proximal airways of antigen-challenged mice

scientific article

Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion

scientific article published on 20 March 2008

Osteopontin in systemic sclerosis and its role in dermal fibrosis

scientific article

P2Y6 and vascular inflammation

scientific article published on 01 February 2011

Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations

scientific article published on 28 October 2005

Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine

scientific article published on 8 May 2008

Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.

scientific article published on 19 December 2016

Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure

scientific article

Response to Letter Regarding Article, "Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia".

scientific article

Retracted: Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion

retracted scientific article

Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury

scientific journal article

Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells

scientific article

STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation

scientific article

Spare PRELI gene loci: failsafe chromosome insurance?

scientific article

Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction

scientific article published on 16 June 2016

Sustained adenosine exposure causes lung endothelial apoptosis: a possible contributor to cigarette smoke-induced endothelial apoptosis and lung injury

scientific article published on 11 January 2013

Sustained adenosine exposure causes lung endothelial barrier dysfunction via nucleoside transporter-mediated signaling

scientific article published on 28 June 2012

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease

scientific article published on 13 March 2012

The importance of adenosine deaminase for lymphocyte development and function.

scientific article

The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis

scientific article

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

scientific article

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

scientific journal article

Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice

scientific article

Transitory expression of the A2b adenosine receptor during implantation chamber development

article

List of works by Michael R. Blackburn

A role for neural pathways in adenosine-induced bronchoconstriction.

A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6'-dimycolate induced granulomatous response

A role of erythrocytes in adenosine monophosphate initiation of hypometabolism in mammals

A semiautomated framework for integrating expert knowledge into disease marker identification

A1 adenosine receptors mediate hypoglycemia-induced neuronal injury.

A1 adenosine receptors mediate hypoxia-induced ventriculomegaly

A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli

A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation

A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation

A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

Abnormal alveolar development associated with elevated adenine nucleosides

Adenosine A2B receptor and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease

Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance

Adenosine and dopamine receptors coregulate photoreceptor coupling via gap junction phosphorylation in mouse retina

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease

Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation

Adenosine deaminase deficiency: unanticipated benefits from the study of a rare immunodeficiency

Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Adenosine mediated desensitization of cAMP signaling enhances T-cell responses

Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway

Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis

Adenosine promotes vascular barrier function in hyperoxic lung injury.

Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement

Adenosine receptors and inflammation

Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease

Adenosine signaling and the regulation of chronic lung disease

Adenosine signaling contributes to ethanol-induced fatty liver in mice.

Adenosine signaling during acute and chronic disease states

Adenosine signaling in asthma and chronic obstructive pulmonary disease

Adenosine signaling, priapism and novel therapies

Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells

Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS)

Animal models of airway diseases

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.

Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia

Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements

Constant darkness is a circadian metabolic signal in mammals

Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice

Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulation

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension

Detrimental effects of adenosine signaling in sickle cell disease

Disease-specific gene expression profiling in multiple models of lung disease

Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injury.

Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines

Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity

Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension

Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia

Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts

Endogenous osteopontin promotes ozone-induced neutrophil recruitment to the lungs and airway hyperresponsiveness to methacholine

Enhanced CXCL1 production and angiogenesis in adenosine-mediated lung disease

Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Excessive Penile Norepinephrine Level Underlies Impaired Erectile Function in Adenosine A1 Receptor Deficient Mice

Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancy

Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis

Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report

Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction

Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues

High Levels of Adenosine Deaminase on Dendritic Cells Promote Autoreactive T Cell Activation and Diabetes in Nonobese Diabetic Mice

Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis.

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.

IL-6 mediates 11βHSD type 2 to effect progression of the mycobacterial cord factor trehalose 6,6'-dimycolate-induced granulomatous response