List of works - Michal Douša

A novel approach for HPLC determination of 2-cynaoacetamide using derivatization procedure with 2-hydroxyacetophenone as a new useful derivatization reagent.

scientific article published on 10 June 2016

Chiral capillary zone electrophoresis in enantioseparation and analysis of cinacalcet impurities: Use of Quality by Design principles in method development

Chiral chromatography studies of chemical behavior of cinacalcet on polysaccharide chiral reversed-phase HPLC stationary phases

scientific article published in November 2012

Chiral separation of aliphatic primary amino alcohols as o-phthaldialdehyde/mercaptoethanol derivatives on polysaccharide-based chiral stationary phases

scientific article published on 17 January 2019

Development, validation and comparison of UHPSFC and UHPLC methods for the determination of agomelatine and its impurities.

scientific article published on 19 April 2016

Direct analysis in real time--high resolution mass spectrometry as a valuable tool for the pharmaceutical drug development.

scientific article published on 21 July 2014

Drug-excipient compatibility testing-Identification and characterization of degradation products of phenylephrine in several pharmaceutical formulations against the common cold

scientific article published on 25 March 2011

Effect of Chromatographic Conditions on Enantioseparation of Bedaquiline Using Polysaccharide-based Chiral Stationary Phases in RP-HPLC.

scientific article published on 12 April 2016

Enantiomeric separation of R,S-tolterodine and R,S-methoxytolterodine with negatively charged cyclodextrins by capillary electrophoresis

scientific article published on 01 May 2013

Enantiomeric separation of tapentadol by capillary electrophoresis--study of chiral selectivity manipulation by various types of cyclodextrins

scientific article published on 22 November 2014

Enantioseparation and impurity determination of ambrisentan using cyclodextrin-modified micellar electrokinetic chromatography: Visualizing the design space within quality by design framework.

scientific article published in July 2016

Enantioseparation of N-acetyl-dl-cysteine as o-phtaldialdehyde derivatives obtained with various primary aliphatic amine additives on polysaccharide-based chiral stationary phases

scientific article published on 08 January 2019

Esterification of Ibuprofen in Soft Gelatin Capsules Formulations-Identification, Synthesis and Liquid Chromatography Separation of the Degradation Products

scientific article published on 01 September 2017

Fundamental study of enantioselective HPLC separation of tapentadol enantiomers using cellulose-based chiral stationary phase in normal phase mode ⬇️

scientific article published on October 24, 2012

General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography

scientific article published on 21 November 2016

HILIC-MS Determination of Genotoxic Impurity of 2-Chloro-N-(2-Chloroethyl)Ethanamine in the Vortioxetine Manufacturing Process

scientific article published on 29 July 2015

HPLC/UV/MS method application for the separation of obeticholic acid and its related compounds in development process and quality control

scientific article published on 4 November 2017

Identification and structure elucidation of a new degradation impurity in the multi-component tablets of amlodipine besylate

scientific article published on 26 July 2018

Identification, characterization, synthesis and HPLC quantification of new process-related impurities and degradation products in retigabine

scientific article published on 03 February 2014

Identification, preparation and UHPLC determination of process-related impurity in zolmitriptan

scientific article published on 16 September 2011

Liquid chromatographic method for enantiopurity control of alaptide using polysaccharide stationary phases ⬇️

scientific article published on 05 May 2011

Liquid chromatographic separation of pregabalin and its possible impurities with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde.

scientific article published in November 2010

New approach of validation using internal normalization technique for quantification of related substances in raw material, intermediates and pharmaceutical substances by HPLC

scientific article published on 22 May 2015

Optimization of o-phtaldialdehyde/2-mercaptoethanol postcolumn reaction for the hydrophilic interaction liquid chromatography determination of memantine utilizing a silica hydride stationary phase

scientific article published on 08 August 2016

Quality by Design as a risk-based strategy in pharmaceutical analysis: Development of a liquid chromatography-tandem mass spectrometry method for the determination of nintedanib and its impurities

scientific article published on 10 October 2019

Quantification of 2-aminoisobutyric acid impurity in enzalutamide bulk drug substance using hydrophilic interaction chromatography with fluorescence detection

scientific article published on 31 October 2018

Quantification of structurally related aliphatic amino alcohols in l-valinol by hydrophilic interaction liquid chromatography separation combined with postcolumn derivatization and fluorescence detection

scientific article published on 28 January 2016

Rapid HILIC method with fluorescence detection using derivatization reaction utilizing o-phthaldialdehyde for determination of degradation product of aliskiren

scientific article published on 17 March 2012

Rapid determination of ambrisentan enantiomers by enantioselective liquid chromatography using cellulose-based chiral stationary phase in reverse phase mode.

scientific article published in April 2012

Rapid hydrophilic interaction chromatography determination of lysine in pharmaceutical preparations with fluorescence detection after postcolumn derivatization with o-phtaldialdehyde

scientific article published on 30 November 2010

Retention behavior of a homologous series and positional isomers of aliphatic amino acids in hydrophilic interaction chromatography

scientific article published on 10 March 2014

Separation of structurally related primary aliphatic amines using hydrophilic interaction chromatography with fluorescence detection after postcolumn derivatization with o-phthaldialdehyde/mercaptoethanol

scientific article

The determination of pharmaceutically active thiols using hydrophilic interaction chromatography followed postcolumn derivatization with o-phthaldialdehyde and fluorescence detection

scientific article published on 16 April 2018

The formation of furfural compounds in selected saccharide- and polysaccharide-based pharmaceutical excipients

scientific article published on 08 February 2012

Underivatized amylose and cellulose as new stationary phases for hydrophilic interaction chromatography.

scientific article published on 17 September 2013

Utilization of Photochemically Induced Fluorescence Detection for HPLC Determination of Genotoxic Impurities in the Vortioxetine Manufacturing Process

scientific article published on 01 October 2016

List of works by Michal Douša