List of works - Mike R. Clark

A humanized monovalent CD3 antibody which can activate homologous complement

scientific article published on 01 November 1991

A simple method for measuring patient anti-globulin responses against isotypic or idiotypic determinants

scientific article published on 01 February 1990

Activation of complement by human IgG1 and human IgG3 antibodies against the human leucocyte antigen CD52.

scientific article published in April 1998

Advantages of rat monoclonal antibodies

scientific article

An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcepsilonRI with FcgammaRIIb.

scientific article published on 7 December 2007

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells

scientific article

Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

scientific article published on April 2000

Chimeric and humanised--misunderstood

scientific article published on 01 April 2000

Clearance of human IgG1-sensitised red blood cells in vivo in humans relates to the in vitro properties of antibodies from alternative cell lines

scientific article

Detection of monoclonal antibodies against cell surface antigens: the use of antiglobulins coupled to red blood cells

scientific article published on 01 January 1984

Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia

scientific article

Differential binding to human FcgammaRIIa and FcgammaRIIb receptors by human IgG wildtype and mutant antibodies

scientific article published in December 2003

Empowering the inventor--the case of monoclonal antibodies.

scientific article published in September 2005

Function-blocking antibodies to human vascular adhesion protein-1: a potential anti-inflammatory therapy

scientific article published in November 2005

Immunohistological screening in the selection of monoclonal antibodies: the use of isotype-specific antiglobulins

scientific article published on 01 April 1984

Interaction of rat monoclonal antibodies with human killer cells

Intravascular survival of red cells coated with a mutated human anti-D antibody engineered to lack destructive activity

scientific article published in December 2005

Low-affinity FcγR interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets.

scientific article published on 16 February 2014

Monoclonal-Antibody Therapy in Systemic Vasculitis

scientific article published on 01 July 1990

PECAM-1 polymorphism affects monocyte adhesion to endothelial cells.

scientific article

Primary sequence and molecular model of the variable region of a mouse monoclonal anti-Der p 1 antibody showing a similar epitope specificity as human IgE.

scientific article published in November 1998

Quantification of the effects of antibodies on the extra- and intracellular dynamics of Salmonella enterica

scientific article

Rapid phenotyping of HPA-1a using either diabody-based hemagglutination or recombinant IgG1-based assays.

scientific article

Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers

scientific article

Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

scientific article published on 14 May 2019

Regulation unmasked by activation.

scientific article published in July 2013

Reshaping human antibodies for therapy

scientific article

Structural motifs involved in human IgG antibody effector functions

scientific article published on 01 May 1993

The INNs and outs of antibody nonproprietary names

scientific article published in January 2016

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function

scientific article

The improved lytic function andin vivo efficacy of monovalent monoclonal CD3 antibodies

scientific article published on 01 February 1989

The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy

scientific article published on 01 January 1988

The use of mouse/human chimaeric antibodies to investigate the roles of different antibody isotypes, including lgA2, in the killing of Schistosoma mansoni schistosomula by eosinophils

scientific article published in March 1993

List of works by Mike R. Clark

A humanized monovalent CD3 antibody which can activate homologous complement

A simple method for measuring patient anti-globulin responses against isotypic or idiotypic determinants

Activation of complement by human IgG1 and human IgG3 antibodies against the human leucocyte antigen CD52.

Advantages of rat monoclonal antibodies

An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcepsilonRI with FcgammaRIIb.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells

Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

Chimeric and humanised--misunderstood

Clearance of human IgG1-sensitised red blood cells in vivo in humans relates to the in vitro properties of antibodies from alternative cell lines

Detection of monoclonal antibodies against cell surface antigens: the use of antiglobulins coupled to red blood cells

Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia

Differential binding to human FcgammaRIIa and FcgammaRIIb receptors by human IgG wildtype and mutant antibodies

Empowering the inventor--the case of monoclonal antibodies.

Function-blocking antibodies to human vascular adhesion protein-1: a potential anti-inflammatory therapy

Immunohistological screening in the selection of monoclonal antibodies: the use of isotype-specific antiglobulins

Interaction of rat monoclonal antibodies with human killer cells

Intravascular survival of red cells coated with a mutated human anti-D antibody engineered to lack destructive activity

Low-affinity FcγR interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets.

Monoclonal-Antibody Therapy in Systemic Vasculitis

PECAM-1 polymorphism affects monocyte adhesion to endothelial cells.

Primary sequence and molecular model of the variable region of a mouse monoclonal anti-Der p 1 antibody showing a similar epitope specificity as human IgE.

Quantification of the effects of antibodies on the extra- and intracellular dynamics of Salmonella enterica

Rapid phenotyping of HPA-1a using either diabody-based hemagglutination or recombinant IgG1-based assays.

Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers

Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

Regulation unmasked by activation.

Reshaping human antibodies for therapy

Structural motifs involved in human IgG antibody effector functions

The INNs and outs of antibody nonproprietary names

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function

The improved lytic function andin vivo efficacy of monovalent monoclonal CD3 antibodies

The potential of hybrid antibodies secreted by hybrid-hybridomas in tumour therapy

The use of mouse/human chimaeric antibodies to investigate the roles of different antibody isotypes, including lgA2, in the killing of Schistosoma mansoni schistosomula by eosinophils