List of works - Frank R. DeLeo

A MRSA-terious enemy among us: Boosting MRSA vaccines

scientific article published on 01 February 2011

A NET Outcome

scientific article

A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response

scientific article

A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence

scientific article

A domain of p47phox that interacts with human neutrophil flavocytochrome b558.

scientific article published on November 1995

A molecular trigger for intercontinental epidemics of group A Streptococcus.

scientific article

A plague upon the phagocytes

scientific article published on 01 September 2005

A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.

scientific article published on September 2009

ADAM17 activity during human neutrophil activation and apoptosis

scientific article published on 01 April 2006

An antidote for Staphylococcus aureus pneumonia?

scientific article published on 11 February 2008

An antidote forStaphylococcus aureuspneumonia?

An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation

scientific article

An update on community-associated MRSA virulence

scientific article published on 31 August 2009

Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils

scientific article published on 13 March 2018

Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox.

scientific article

Attractive shedding ⬇️

scientific article published on September 15, 2007

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

scientific article

Axis of Coinfection Evil

scientific article published on 01 February 2010

Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils

scientific article

Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.

scientific article published on February 1999

Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

scientific article

Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva

scientific article

Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins

scientific article

Characterization of peptide diffusion into electropermeabilized neutrophils

scientific article published on 01 October 1996

Community-associated methicillin-resistant Staphylococcus aureus and athletes

scientific article published on May 2012

Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence

scientific article

Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factors

scientific article published on April 2008

Community-associated meticillin-resistant Staphylococcus aureus

scientific article

Community-associated meticillin-resistant Staphylococcus aureus – Authors' reply

scientific article published in The Lancet

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection

scientific article

Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains

scientific article

Complete nucleotide sequence analysis of plasmids in strains of Staphylococcus aureus clone USA300 reveals a high level of identity among isolates with closely related core genome sequences

scientific article

Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis

scientific article

Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection

scientific article

Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis

scientific article

Dectin-1 promotes fungicidal activity of human neutrophils

scientific article published on 01 February 2007

Despite structural similarities between gp91phox and FRE1, flavocytochrome b558 does not mediate iron uptake by myeloid cells

scientific article published in September 1999

Differential distribution and expression of Panton-Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strains

scientific article

Epidemic Klebsiella pneumoniae ST258 is a hybrid strain

scientific article

Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification.

scientific article

Evasion of Neutrophil Killing by Staphylococcus aureus

scientific article

Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis ⬇️

scientific article published on December 1, 2001

Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus

scientific article

Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus

scholarly article

Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response

scientific article

Flexicate molecules as a potential new class of antibiotics

scientific article published on April 2012

Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis

scientific article published on 14 September 2012

Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease

scientific article published in 2008

Genome-Scale Transcript Analyses with Human Neutrophils

scientific article published on 01 January 2014

Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity

scientific article

Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections

scholarly article

Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes

scholarly article

Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis

scientific article published on 06 September 2016

Genomic analysis of the emergence of vancomycin-resistant Staphylococcus aureus

scientific article

Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection

scientific article

Global changes in Staphylococcus aureus gene expression in human blood

scientific article

Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression

scientific article

Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).

scientific article published on 18 June 2001

Host Response to Staphylococcus aureus Quorum Sensing Is NO.

scientific article

Host defense and pathogenesis in Staphylococcus aureus infections

scientific article published on March 2009

Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics

scientific article

Host-pathogen interactions: leukocyte phagocytosis and associated sequelae

scientific article published in January 2002

Host–Pathogen Interactions

How methicillin-resistant Staphylococcus aureus evade neutrophil killing

scientific article

Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes

scientific article

Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes

scientific article

Identification of Outer Membrane and Exoproteins of Carbapenem-Resistant Multilocus Sequence Type 258 Klebsiella pneumoniae

scientific article

Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties

scientific article published on 28 February 2012

Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics

scientific article

Inflammation in 3D

scientific article published on 01 June 2012

Influence of Microbes on Neutrophil Life and Death

scientific article

Innate immunity against Granulibacter bethesdensis, an emerging gram-negative bacterial pathogen

scientific article published on 19 December 2011

Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide

scientific article

Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells

scientific article

Insights into the Staphylococcus aureus-host interface: global changes in host and pathogen gene expression in a rabbit skin infection model

scientific article

Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

scientific article published on 18 February 2019

Interaction of Staphylococci with Human B cells

scientific article

Interaction of human neutrophil flavocytochrome b with cytosolic proteins: transferred-NOESY NMR studies of a gp91phox C-terminal peptide bound to p47phox.

scientific article published on July 1997

Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus

scientific article

Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

scientific article published on 19 August 2015

Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?

scientific article

Key role of poly-γ-dl-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis

Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates

scientific article

Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx

scientific article

Maturation of human neutrophil phagosomes includes incorporation of molecular chaperones and endoplasmic reticulum quality control machinery

scientific article published on 14 January 2006

Memorial: Gary Michael Bokoch, 1954-2010.

scientific article published in April 2010

Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA

scientific article

Mobile genetic elements of Staphylococcus aureus

scientific article

Modulation of phagocyte apoptosis by bacterial pathogens.

scientific article published on July 2004

Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus

scientific article published on 24 October 2011

Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae

scientific article

Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus

scientific article

Molecular pathogenesis lessons from the world of infectious diseases research

scientific article published on 21 April 2015

Mouse Model of Staphylococcus aureus Skin Infection

scientific article published on 01 January 2019

Mouse model of Staphylococcus aureus skin infection

scientific article published on January 2013

Multiplex PCR for identification of two capsular types in epidemic KPC-producing Klebsiella pneumoniae sequence type 258 strains

scientific article

NET Confusion

scientific article published on 28 June 2016

Neutrophil apoptosis and the resolution of infection

scientific article published on January 2009

Neutrophil isolation from nonhuman species.

scientific article published on January 2014

Neutrophils and Bacterial Immune Evasion.

scientific article

Neutrophils in innate host defense against Staphylococcus aureus infections

scientific article

Neutrophils in innate immunity and systems biology-level approaches

scientific article published on 20 June 2019

Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes

scientific article

PI3K and NADPH oxidase: a class act.

scientific article

Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease

scientific article published on October 2008

Pathogenesis of Staphylococcus aureus abscesses

scientific article

Phagocytosis and Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils

scientific article published on 14 January 2016

Phagocytosis and killing of Staphylococcus aureus by human neutrophils

scientific article

Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis

scientific article

Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors

scientific article

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.

scientific article

Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system

scientific article published on 01 March 2004

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia

scientific article

Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response

scientific article

Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus

scientific article published on 11 January 2012

Processing and Maturation of Flavocytochromeb558Include Incorporation of Heme as a Prerequisite for Heterodimer Assembly

scientific article published in Journal of Biological Chemistry

Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus

scientific article published on 26 June 2010

Re-evaluating the potential of immunoprophylaxis and/or immunotherapy for infections caused by multidrug resistant Klebsiella pneumoniae

scientific article published on 26 September 2018

Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era.

scientific article published on September 2009

Regulation of the neutrophil-mediated inflammatory response to infection

scientific article published on November 2003

Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils.

scientific article

Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants

scientific article

Reply to Kernodle and to Schwartzman et al

scientific article published in 2007

Reply to Kernodle.

scientific article published in June 2011

Reply to Vandenesch et al

scientific article published in 2010

Role of NF-κB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-α

scientific article published on 31 May 2007

Role of neutrophils in innate immunity: a systems biology-level approach

scientific article

STAT3 mutations in the hyper-IgE syndrome

scientific article

Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model

scientific article

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance

scientific article (publication date: June 2014)

Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis.

scientific article

Staphylococcus Aureus and Polymicrobial Skin and Soft Tissue Infections

scientific article published on 02 October 2018

Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps

scientific article

Staphylococcus aureus leukotoxin GH promotes inflammation

scientific article

Staphylococcus aureus protein A promotes immune suppression

scientific article published on October 2013

Staphylococcus epidermidis strategies to avoid killing by human neutrophils

scientific article

Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogens

scientific article published in October 2004

Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity

scientific article

Survival of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 in Human Blood

scientific article published on 23 January 2017

Systems biology and innate immunity

scientific article published on 21 February 2013

Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model

scientific article

The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus

scientific article

The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus

scientific article

The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction

scientific article published on July 2006

The role of neutrophils in the immune system: an overview.

scientific article published on January 2014

Toward an understanding of the evolution of Staphylococcus aureus strain USA300 during colonization in community households

scientific article published on January 2012

Towards a Monoclonal Antibody-Based Therapy for Prevention and Treatment of Staphylococcus aureus Infections

scientific article published on 01 February 2019

Transmission of Yersinia pestis from an infectious biofilm in the flea vector

scientific article published on 12 July 2004

Variants of the 5′-untranslated region of human NCF2: Expression and translational efficiency

article

Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin

scientific article published on 18 April 2013

Waves of resistance: Staphylococcus aureus in the antibiotic era.

scientific article

List of works by Frank R. DeLeo

A MRSA-terious enemy among us: Boosting MRSA vaccines

A NET Outcome

A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response

A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence

A domain of p47phox that interacts with human neutrophil flavocytochrome b558.

A molecular trigger for intercontinental epidemics of group A Streptococcus.

A plague upon the phagocytes

A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.

ADAM17 activity during human neutrophil activation and apoptosis

An antidote for Staphylococcus aureus pneumonia?

An antidote forStaphylococcus aureuspneumonia?

An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation

An update on community-associated MRSA virulence

Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils

Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox.

Attractive shedding ⬇️

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

Axis of Coinfection Evil

Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils

Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum.

Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva

Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins

Characterization of peptide diffusion into electropermeabilized neutrophils

Community-associated methicillin-resistant Staphylococcus aureus and athletes

Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence

Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factors

Community-associated meticillin-resistant Staphylococcus aureus

Community-associated meticillin-resistant Staphylococcus aureus – Authors' reply

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection

Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains

Complete nucleotide sequence analysis of plasmids in strains of Staphylococcus aureus clone USA300 reveals a high level of identity among isolates with closely related core genome sequences

Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis

Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection

Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis

Dectin-1 promotes fungicidal activity of human neutrophils

Despite structural similarities between gp91phox and FRE1, flavocytochrome b558 does not mediate iron uptake by myeloid cells

Differential distribution and expression of Panton-Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strains

Epidemic Klebsiella pneumoniae ST258 is a hybrid strain

Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification.

Evasion of Neutrophil Killing by Staphylococcus aureus

Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis ⬇️

Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus

Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus

Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response

Flexicate molecules as a potential new class of antibiotics

Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis

Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease

Genome-Scale Transcript Analyses with Human Neutrophils

Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity

Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections

Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes

Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis

Genomic analysis of the emergence of vancomycin-resistant Staphylococcus aureus

Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection

Global changes in Staphylococcus aureus gene expression in human blood

Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression

Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox).

Host Response to Staphylococcus aureus Quorum Sensing Is NO.

Host defense and pathogenesis in Staphylococcus aureus infections

Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics

Host-pathogen interactions: leukocyte phagocytosis and associated sequelae

Host–Pathogen Interactions

How methicillin-resistant Staphylococcus aureus evade neutrophil killing

Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes

Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes

Identification of Outer Membrane and Exoproteins of Carbapenem-Resistant Multilocus Sequence Type 258 Klebsiella pneumoniae

Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties

Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics

Inflammation in 3D

Influence of Microbes on Neutrophil Life and Death

Innate immunity against Granulibacter bethesdensis, an emerging gram-negative bacterial pathogen

Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide

Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells

Insights into the Staphylococcus aureus-host interface: global changes in host and pathogen gene expression in a rabbit skin infection model

Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

Interaction of Staphylococci with Human B cells

Interaction of human neutrophil flavocytochrome b with cytosolic proteins: transferred-NOESY NMR studies of a gp91phox C-terminal peptide bound to p47phox.

Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus