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List of works by Colm Cunningham

A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning

scientific article published on 6 February 2009

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

scientific article published on 08 June 2020

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

scientific article published on 06 June 2018

Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease

scientific article published on 7 November 2007

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

scientific article published on 18 January 2017

Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study

scientific article published on 28 September 2017

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α.

scientific article published on June 2015

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

scientific article published on 17 November 2018

At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.

scientific article published on 28 February 2015

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response ⬇️

scientific article published on August 3, 2012

Atypical inflammation in the central nervous system in prion disease

scientific article

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

scientific article

Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls

scientific article

Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1β in delirium after hip fracture

scientific article

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

scientific article published on 25 January 2019

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.

scientific article published on 24 March 2015

Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease

scientific article published on April 2005

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1β, TNF-α and IL-6 Challenges in C57BL/6 Mice.

scientific article

Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

scientific article published on 01 October 2019

Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction

scientific article published on September 2013

Cytokines and the ageing brain

scientific article published in November 2002

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

scientific article

Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

scientific article

Differential response of hippocampal and prefrontal oscillations to systemic LPS application

scientific article published on 30 December 2017

Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.

scientific article

Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice

scientific article

Environmental influences on antibody-enhanced dengue disease outcomes.

scientific article published on December 2012

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6 ⬇️

scientific article published on May 17, 2011

Hippocampal lesions can enhance discrimination learning despite normal sensitivity to interference from incidental information

scientific article

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

scientific article

Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies

scientific article published on 01 October 2000

Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice

scientific article

Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.

scientific article published on 18 April 2015

Losing Sleep Over Delirium

scientific article published on 01 June 2018

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring.

scientific article published on 28 February 2008

MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease

scientific article published in November 2005

Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory.

scientific article

Microglia and neurodegeneration: the role of systemic inflammation.

scientific article published on 06 June 2012

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.

scientific article

Neuroinflammation in delirium: a postmortem case-control study

scientific article

Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease.

scientific article

New horizons in the pathogenesis, assessment and management of delirium.

scientific article published on 25 September 2013

Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?

scientific article

Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

scientific article published in January 2002

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

scientific article published on 23 September 2024

Proinflammatory cytokines, sickness behavior, and Alzheimer disease ⬇️

scientific article published on July 13, 2011

Reduce the burden of dementia now

scientific article published on 28 June 2018

Risk factors for postoperative delirium.

scientific article published on 5 November 2014

Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.

scientific article published on 23 March 2007

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

scientific article

Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

scientific article published on 12 September 2016

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration

scientific article published on 23 April 2010

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

scientific article

Systemic inflammation and delirium: important co-factors in the progression of dementia.

scientific article published on August 2011

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease

scientific article published on 18 September 2008

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium.

scientific article

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

scientific article published on 23 December 2007

TGFbeta1 regulates the inflammatory response during chronic neurodegeneration

scientific article published on 28 February 2006

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

scientific article published on 29 February 2016

The impact of systemic infection on the progression of neurodegenerative disease.

scientific article

Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix

scientific article published on 01 April 2002

Unaltered SNARE complex formation in an in vivo model of prion disease

scientific article published on 30 July 2008

Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses

scientific article published on September 2008

Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium

scientific article

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