List of works - Stefano Thellung

A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+

scientific article published on 01 December 1999

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

scientific article published on January 2007

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells

scientific article published on January 2007

Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126

scientific article published on 01 August 2000

CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis.

scientific article

Ca(2+)-ATPase pump forms and an endogenous inhibitor in bovine brain synaptosomes

scientific article

Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

scientific article

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

scientific article published on 18 November 2014

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

scientific article

Characterization of two central AMPA-preferring receptors having distinct location, function and pharmacology.

scientific article

Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.

scientific article published on April 2006

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants

scientific article published on 04 October 2007

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

scientific article published on 26 February 2009

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

scientific article published on 01 November 2007

Effect of nitric oxide donors on GABA uptake by rat brain synaptosomes

scientific article published in December 1997

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

scientific article

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

scientific article

Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment

scientific article published on 2 August 2012

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

scientific article published in July 2002

Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity.

scientific article published in January 2004

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

scientific article published on 19 November 2010

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

scientific article

Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation.

scientific article

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

scientific article

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

scientific article

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

scientific article

Intracellular transducing mechanisms coupled to brain somatostatin receptors.

scientific article published on June 1996

Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential.

scientific article published on 16 February 2012

Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

scientific article published on 04 August 2015

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

scientific article published on 21 November 2007

Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling

scientific article published on 08 February 2012

Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells

scientific article published in September 1996

Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide

scientific article published in November 2002

Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes

scientific article published on 01 January 1999

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

scientific article published on December 2003

Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats.

scientific article published on October 1999

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

scientific article published on January 2012

Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex.

scientific article

Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation

scientific article

SDF-1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2.

scientific article published on December 2006

Serotonergic inhibition of the mossy fibre--granule cell glutamate transmission in rat cerebellar slices

scientific article published in October 1993

Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro

scientific article published on 01 October 1999

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

scientific article published on April 2003

TGF-beta1 prevents gp120-induced impairment of Ca2+ homeostasis and rescues cortical neurons from apoptotic death

scientific article published in September 1997

[Somatostatinergic control of Kaposi's sarcoma growth through the inhibition of angiogenesis]

scientific article published on 01 December 2001

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells

scientific article published on February 2002

List of works by Stefano Thellung

A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells

Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126

CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis.

Ca(2+)-ATPase pump forms and an endogenous inhibitor in bovine brain synaptosomes

Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

Characterization of two central AMPA-preferring receptors having distinct location, function and pharmacology.

Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

Effect of nitric oxide donors on GABA uptake by rat brain synaptosomes

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity.

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation.

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

Intracellular transducing mechanisms coupled to brain somatostatin receptors.

Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential.

Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling

Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells

Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide

Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats.

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex.

Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation

SDF-1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2.

Serotonergic inhibition of the mossy fibre--granule cell glutamate transmission in rat cerebellar slices

Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

TGF-beta1 prevents gp120-induced impairment of Ca2+ homeostasis and rescues cortical neurons from apoptotic death

[Somatostatinergic control of Kaposi's sarcoma growth through the inhibition of angiogenesis]

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells