List of works - Paul Eggleton

A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity.

scientific article published on 26 October 2013

A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins.

scientific article

A mechanism of release of calreticulin from cells during apoptosis

scientific article

A second serine protease associated with mannan-binding lectin that activates complement

scientific article

Are Rheumatoid Factor, Anti-Citrullinated Protein Antibodies, and Anti-Carbamylated Protein Antibodies Linked by Posttranslational Modification of IgG? Comment on the Article by Koppejan et al.

scientific article published on 2 August 2016

Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus

article

Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

scientific article published on February 2004

Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages.

scientific article

Bronchiectasis is a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis.

scientific article published on 27 May 2015

C-REACTIVE PROTEIN AND LIVER VIABILITY AFTER TRANSPLANTATION

scientific article published in The Lancet

C1q receptors.

scientific article

C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms

scientific article

C1qâ how many functions? How many receptors?

scientific article published on 01 November 1998

CD20(+) T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer

scientific article

CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

scientific article published on 12 June 2014

Calreticulin comes of age

scientific article published on 01 September 2000

Calreticulin for better or for worse, in sickness and in health, until death do us part.

scientific article published on 12 June 2013

Calreticulin, a therapeutic target?

scientific article published on 9 March 2016

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

scientific article

Carbamylation/citrullination of IgG Fc in bronchiectasis, established RA with bronchiectasis and RA smokers: a potential risk factor for disease

scientific article published in July 2017

Changes in Apoptotic Gene Expression in Lymphocytes from Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Compared with Healthy Lymphocytes

article

Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions.

scientific article

Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils

scientific article published on 01 September 1994

Clinical relevance of calreticulin in systemic lupus erythematosus

scientific article published on January 1997

Could Autophagy Induced by Misfolded Mutant α1 -Antitrypsin Z in Synovitis Explain the Association of α1 -Antitrypsin Z With Increased Anti-Citrullinated Protein Antibody Production in Rheumatoid Arthritis? Comment on the Article by McCarthy et al

scientific article

Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species.

scientific article published in January 2014

Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens

scientific article published on 12 December 2012

Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping

scientific article published on January 2008

Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis.

scientific article published on November 1995

Direct and Indirect Rituximab-Induced T Cell Depletion: Comment on the Article by Mélet et al

scientific article published on 01 April 2014

Editorial: Endoplasmic Reticulum and Its Role in Tumor Immunity

scientific article published on 17 November 2015

Effect of IP6 on human neutrophil cytokine production and cell morphology

scientific article published on 01 September 1999

Evidence That C1q Binds Specifically to CH2-like Immunoglobulin γ Motifs Present in the Autoantigen Calreticulin and Interferes with Complement Activation†

article

Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.

scientific article

Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex

scientific article published on 01 August 1997

Expression and Purification of Mammalian Calreticulin in Pichia pastoris

scientific article published on 01 November 2000

Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells

scientific article

Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization

article published in 2000

Fractionation of human neutrophils into subpopulations by countercurrent distribution: surface charge and functional heterogeneity

scientific article published on 01 April 1992

Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q.

scientific article published on July 1998

Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes

scientific article published on 19 August 2019

Galectin-9 activates and expands human T-helper 1 cells.

scientific article

Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity.

scientific article

Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis

scientific article published on 23 June 2017

Heterogeneity in the circulating neutrophil pool: studies on subpopulations separated by continuous flow electrophoresis.

scientific article published on June 1992

Hunterian Institute

scientific article published in Nature

Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules.

scientific article published on 8 January 2009

Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation.

scientific article

Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R.

scientific article published on April 1995

Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS)

article

Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides.

scientific article

Immune function of C1q and its modulators CD91 and CD93.

scientific article

Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus

scientific article published on 01 May 2006

Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis.

scientific article published on 22 July 2015

Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils

scientific article published on 01 November 1997

Lung surfactant proteins involved in innate immunity.

scientific article

Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death

scientific article

Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against.

scientific article published in January 2017

Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.

scientific article published on October 2011

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.

scientific article

Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus

scientific article published on 01 January 2014

Nitric oxide and the regulation of apoptosis in tumour cells.

scientific article published on January 2006

Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils

scientific article published on 01 May 1997

RA autoantibodies as predictors of rheumatoid arthritis in non-cystic fibrosis bronchiectasis patients

scientific article published on 25 June 2014

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

scientific article published on 23 January 2017

Rapid method for the isolation of neutrophils in high yield without the use of dextran or density gradient polymers

article

Release of calreticulin from neutrophils may alter C1q-mediated immune functions.

scientific article published on March 1997

Stress protein-polypeptide complexes acting as autoimmune triggers

scientific article published on 01 October 2003

The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.

scientific article

The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.

scientific article

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

scientific article

The ever-expanding immunomodulatory role of calreticulin in cancer immunity

scientific article

The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells

scientific article

The ins and outs of calreticulin: from the ER lumen to the extracellular space.

scientific article

The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?

scientific article

The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse

scientific article published on 28 October 2013

The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester.

scientific article published on December 2002

The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes.

scientific article

Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin

scientific article published on 01 November 2000

Unfolding the complexities of ER chaperones in health and disease: report on the 11th international calreticulin workshop

scientific article

Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D.

scientific article

List of works by Paul Eggleton

A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity.

A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins.

A mechanism of release of calreticulin from cells during apoptosis

A second serine protease associated with mannan-binding lectin that activates complement

Are Rheumatoid Factor, Anti-Citrullinated Protein Antibodies, and Anti-Carbamylated Protein Antibodies Linked by Posttranslational Modification of IgG? Comment on the Article by Koppejan et al.

Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus

Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages.

Bronchiectasis is a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis.

C-REACTIVE PROTEIN AND LIVER VIABILITY AFTER TRANSPLANTATION

C1q receptors.

C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms

C1qâ how many functions? How many receptors?

CD20(+) T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer

CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

Calreticulin comes of age

Calreticulin for better or for worse, in sickness and in health, until death do us part.

Calreticulin, a therapeutic target?

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

Carbamylation/citrullination of IgG Fc in bronchiectasis, established RA with bronchiectasis and RA smokers: a potential risk factor for disease

Changes in Apoptotic Gene Expression in Lymphocytes from Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Compared with Healthy Lymphocytes

Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions.

Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils

Clinical relevance of calreticulin in systemic lupus erythematosus

Could Autophagy Induced by Misfolded Mutant α1 -Antitrypsin Z in Synovitis Explain the Association of α1 -Antitrypsin Z With Increased Anti-Citrullinated Protein Antibody Production in Rheumatoid Arthritis? Comment on the Article by McCarthy et al

Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species.

Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens

Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping

Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis.

Direct and Indirect Rituximab-Induced T Cell Depletion: Comment on the Article by Mélet et al

Editorial: Endoplasmic Reticulum and Its Role in Tumor Immunity

Effect of IP6 on human neutrophil cytokine production and cell morphology

Evidence That C1q Binds Specifically to CH2-like Immunoglobulin γ Motifs Present in the Autoantigen Calreticulin and Interferes with Complement Activation†

Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.

Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex

Expression and Purification of Mammalian Calreticulin in Pichia pastoris

Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells

Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization

Fractionation of human neutrophils into subpopulations by countercurrent distribution: surface charge and functional heterogeneity

Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q.

Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes

Galectin-9 activates and expands human T-helper 1 cells.

Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity.

Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis

Heterogeneity in the circulating neutrophil pool: studies on subpopulations separated by continuous flow electrophoresis.

Hunterian Institute

Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules.

Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation.

Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R.

Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS)

Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides.

Immune function of C1q and its modulators CD91 and CD93.

Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus

Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis.

Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils

Lung surfactant proteins involved in innate immunity.

Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death

Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against.

Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.

Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus

Nitric oxide and the regulation of apoptosis in tumour cells.

Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils

RA autoantibodies as predictors of rheumatoid arthritis in non-cystic fibrosis bronchiectasis patients

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

Rapid method for the isolation of neutrophils in high yield without the use of dextran or density gradient polymers

Release of calreticulin from neutrophils may alter C1q-mediated immune functions.

Stress protein-polypeptide complexes acting as autoimmune triggers

The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.

The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

The ever-expanding immunomodulatory role of calreticulin in cancer immunity

The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells

The ins and outs of calreticulin: from the ER lumen to the extracellular space.

The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?

The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse

The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester.

The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes.

Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin