List of works - Daniel H Gray

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

scientific article published on 05 December 2018

A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-15

scientific article published on 2 April 2007

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

scientific article

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

scientific article published on 04 December 2018

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

scientific article published on 06 December 2012

An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.

scientific article published on 14 July 2017

Analysis of thymic stromal cell populations using flow cytometry

scientific article published in February 2002

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.

scientific article published on 22 September 2016

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

scientific article published on 06 May 2015

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

scientific article published on 07 June 2021

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 + regulatory T cells

scientific article published on 26 June 2019

CCR7 signals are essential for cortex-medulla migration of developing thymocytes.

scientific article published on 9 August 2004

CIS is a potent checkpoint in NK cell-mediated tumor immunity

scientific article

Can you rely on Treg cells on the rebound?

scientific article

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

scientific article published on 5 January 2017

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

scientific article published on 13 January 2017

Characterization of Blimp-1 function in effector regulatory T cells

scientific article published on 30 April 2018

Characterization of a novel human BFL-1-specific monoclonal antibody

scientific article published on 12 November 2019

Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers

scientific article published on 19 July 2019

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

scientific article

Controlling the thymic microenvironment.

scientific article

Correction

Correction: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus.

scientific article published on 25 May 2011

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

scientific article published on 27 January 2020

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

scientific article

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

scientific article published on 8 August 2006

Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.

scientific article published on 16 December 2015

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

scientific article published on 03 April 2020

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

scientific article published on 19 November 2018

Effects of castration on thymocyte development in two different models of thymic involution

scientific article published on 01 September 2005

Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.

scientific article

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

scientific article

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

scientific article published in December 2004

Genetic interrogation of circulating multiple myeloma cells at single-cell resolution

scientific article

Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

scientific article

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

scientific article

Homeostatic control of regulatory T cell diversity.

scientific article published on 31 January 2014

How do thymic epithelial cells die?

scientific article published on 16 March 2018

Immune homeostasis in health and disease

scientific article published on 01 May 2018

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice

scientific article published on 18 June 2015

Isolation of thymic epithelial cells and analysis by flow cytometry.

scientific article

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

scientific article published on 22 November 2005

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

scientific article published on 18 November 2016

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation

scientific article

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected

scientific article published on 01 November 2007

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells

scientific article published on 01 July 2020

Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus

scientific article published on 14 August 2014

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

scientific article published on 12 February 2019

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

scientific article

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

scientific article published on 12 November 2018

Reinforcing the 'gauntlet' of thymic negative selection via exosomal transfer of self-antigens.

scientific article published on 2 June 2015

Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

scientific article published on 07 September 2020

Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

scientific article (publication date: February 2002)

Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex

scientific article published on 01 October 2002

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment.

scientific article published on 2 March 2018

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

scientific article published on 17 October 2019

The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

scientific article published on 29 November 2011

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

scientific article

The thymic medulla: who needs it?

scientific article published on 27 August 2013

The transcriptional landscape of αβ T cell differentiation

scientific article

Thymic generation and regeneration

scientific article

Thymospheres Are Formed by Mesenchymal Cells with the Potential to Generate Adipocytes, but Not Epithelial Cells.

scientific article published in October 2017

Thymus and Tolerance in Transplantation

Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis.

scientific article published on 30 October 2013

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

scientific article published on 08 August 2016

Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4+ T Cells

scientific article published on 03 August 2020

Uhrf to Treg cells: reinforcing the mucosal peacekeepers.

scientific article

Unbiased analysis, enrichment and purification of thymic stromal cells

scientific article published in January 2008

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

scientific article published on 01 October 2020

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

XIAP discriminates between type I and type II FAS-induced apoptosis

scientific article

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

scientific article published on 9 May 2013

List of works by Daniel H Gray

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-15

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.

Analysis of thymic stromal cell populations using flow cytometry

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3 + regulatory T cells

CCR7 signals are essential for cortex-medulla migration of developing thymocytes.

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Can you rely on Treg cells on the rebound?

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

Characterization of Blimp-1 function in effector regulatory T cells

Characterization of a novel human BFL-1-specific monoclonal antibody

Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Controlling the thymic microenvironment.

Correction

Correction: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus.

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Effects of castration on thymocyte development in two different models of thymic involution

Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

Genetic interrogation of circulating multiple myeloma cells at single-cell resolution

Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

Homeostatic control of regulatory T cell diversity.

How do thymic epithelial cells die?

Immune homeostasis in health and disease

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice

Isolation of thymic epithelial cells and analysis by flow cytometry.

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells

Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Reinforcing the 'gauntlet' of thymic negative selection via exosomal transfer of self-antigens.

Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment.

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

The thymic medulla: who needs it?

The transcriptional landscape of αβ T cell differentiation

Thymic generation and regeneration

Thymospheres Are Formed by Mesenchymal Cells with the Potential to Generate Adipocytes, but Not Epithelial Cells.

Thymus and Tolerance in Transplantation

Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis.

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4+ T Cells

Uhrf to Treg cells: reinforcing the mucosal peacekeepers.

Unbiased analysis, enrichment and purification of thymic stromal cells

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

VDAC2 enables BAX to mediate apoptosis and limit tumor development

XIAP discriminates between type I and type II FAS-induced apoptosis

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.