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List of works by Rajesh Khanna

'Fractional recovery' analysis of a presynaptic synaptotagmin 1-anchored endocytic protein complex

scientific article

(-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels

scientific article published on 20 December 2018

(Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents

scientific article published on 03 July 2013

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

scientific article published on 7 April 2015

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

scientific article published on 09 March 2016

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

scientific article published on 11 May 2020

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

scientific article published on 6 September 2018

A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY.

scientific article

A light-gated potassium channel for sustained neuronal inhibition

scientific article published on 30 October 2018

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

scientific article published on July 2015

A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies

scientific article published on 10 June 2020

A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome

scientific article published on 16 July 2018

A porcine model of neurofibromatosis type 1 that mimics the human disease

scientific article published on 21 June 2018

A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners

scientific journal article

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

scientific article

ALTERED CALCIUM CURRENTS AND AXONAL GROWTH IN Nf1 HAPLOINSUFFICIENT MICE

scientific article

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons

scientific article published on 01 December 2019

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels

scientific journal article

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1

scientific article published on 01 November 2019

Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity.

scientific article

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

scientific article published on 01 January 2019

CHARACTERIZING CALCIUM INFLUX VIA VOLTAGE- AND LIGAND-GATED CALCIUM CHANNELS IN EMBRYONIC ALLIGATOR NEURONS IN CULTURE.

scientific article published on September 2013

CHOROID PLEXUS PAPILLOMA OF THIRD VENTRICLE: Case Report

scientific article published on October 1998

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

scientific article published on 3 July 2017

CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy

scientific article

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.

scientific article published on 28 June 2017

CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain

CRMP2 is necessary for Neurofibromatosis type 1 related pain.

scientific article published on 24 August 2017

CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking

scientific article published on 08 July 2013

CRMP2-Neurofibromin Interface Drives NF1-related Pain

scientific article published on 12 April 2018

CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ25-35-induced neurotoxicity by inhibiting the pCRMP2/NMDAR2B signaling pathway

scientific article published on 12 March 2019

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.

scientific article

CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases

scientific article published on 16 June 2015

Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels

scientific article published on 08 August 2001

Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain

scientific article

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

scientific article published on 26 July 2018

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.

scientific article published on 26 September 2012

Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides

scientific article published on 03 July 2013

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

scientific article published on 06 August 2018

Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lac

scientific article

Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.

scientific article published on 11 April 2015

Collapsin Response Mediator Proteins: Novel Targets for Alzheimer's Disease

scientific article published on 06 August 2020

Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity

scientific article published on 28 January 2014

Collapsin response mediator protein 3 increases the dendritic arborization of hippocampal neurons

scientific article published in September 2015

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

scientific article published on 01 December 2021

Compensatory anion currents in Kv1.3 channel-deficient thymocytes

scientific article published on 22 July 2003

Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant

scientific article published on 15 July 2019

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

scientific article

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

scientific article published on 02 May 2019

Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.

scientific article

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury

scientific article published on 22 June 2020

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

scientific article

Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury.

scientific article

Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68)

scientific article published on 03 April 2019

Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties

scientific article published on 16 January 2013

Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

scientific article

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

scientific article published on 31 July 2017

Druggability of CRMP2 for neurodegenerative diseases

scientific article published on 21 July 2020

Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking

scientific article published on 29 July 2019

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

scientific article published on 27 March 2019

Effect of CRMP3 expression on dystrophic dendrites of hippocampal neurons

scientific article published on 22 February 2011

Efficacy of (S)-Lacosamide in preclinical models of cephalic pain

scientific article published on June 2016

Emerging roles of collapsin response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission

scientific article

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

scientific article published on 01 December 2019

Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief

scientific article published on 01 December 2019

Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial

scientific article published on 09 September 2020

Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

scientific article published on 20 December 2020

Eye donation - awareness and willingness among attendants of patients at various clinics in Melaka, Malaysia

scientific article (publication date: 2011)

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel–CRMP-2 signaling complex ⬇️

scientific article published on September 1, 2011

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential

scientific article

Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial

scientific article published on 06 November 2020

Health research strengthening and operational research needs for improving child survival in India.

scientific article

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

scientific article published on 08 December 2016

High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons

scientific article published on 27 September 2018

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

scientific article published on 5 February 2017

Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.

scientific article

Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation

scientific article

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

scientific article

Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.

scientific article published on August 2017

In Reply

In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

scientific article

In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein

scientific article published on 23 September 2020

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

scientific article published on 01 October 2018

Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides

scientific article

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

scientific article published in February 2017

Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain

scientific article

Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics

scientific article published on 27 January 2019

Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.

scientific article published on January 2007

N type Ca2+ channels and RIM scaffold protein covary at the presynaptic transmitter release face but are components of independent protein complexes

scientific article published on 6 June 2006

Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels

scientific article

Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol.

scientific article published on 27 June 2013

Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling.

scientific article

Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis

scientific article published on 01 January 2019

Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteins

scientific article

Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2)

scientific article

Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.

scientific article published on November 2012

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission

scientific article published on 18 December 2018

Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization.

scientific article

Primary health care and child survival in India

scientific article published on 09 March 2010

Putative roles of SLC7A5 (LAT1) transporter in pain

scientific article published on 30 June 2020

QUANTITATIVE RT-PCR ANALYSES OF FIVE EVOLUTIONARY CONSERVED GENES IN ALLIGATOR BRAINS DURING DEVELOPMENT.

scientific article published on December 2011

Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.

scientific article

Regulation of Kv1.3 channels in activated human T lymphocytes by Ca(2+)-dependent pathways

scientific article published on 01 January 2001

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons.

scientific article published on 10 November 2009

Repository on maternal child health: health portal to improve access to information on maternal child health in India

scientific article

Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.

scientific article published on 10 April 2018

Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels

scientific article published on 18 April 2019

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

scientific article published on 24 August 2020

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

scientific article published on 01 October 2020

SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons

scientific article published on 19 March 2013

Sculpting Dendritic Spines during Initiation and Maintenance of Neuropathic Pain

scientific article published on 01 September 2020

Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.

scientific article published on 11 May 2016

Shilajit: a review

scientific article published on May 2007

Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

scientific article published on 27 August 2019

Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis

scientific article

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

scientific journal article

Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide

scientific article

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

scientific article published on 11 June 2020

Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels

scientific article

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex

scientific article published on 5 June 2011

Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide

scientific article published on 20 January 2013

Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation.

scientific article published on June 2000

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

scientific article published on September 2016

Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

scientific article published on 03 July 2020

TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex

scientific article published on 22 July 2019

TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

scientific article published on 30 December 2019

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

scientific article published on 01 July 2020

Targeting Multiple Conformations Leads to Small Molecule Inhibitors of the uPAR·uPA Protein–Protein Interaction That Block Cancer Cell Invasion ⬇️

scientific article published on September 29, 2011

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

scientific article

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

scientific article published on 01 July 2019

Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission

scientific article published on 06 December 2019

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area

scientific article published on 16 April 2021

The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels

scientific article published on 21 November 2019

The Septum-Hippocampal Cholinergic Circuit: A Novel Pathway for Seizure Control

scientific article published on 01 May 2020

The effects, safety and acceptability of compact, pre-filled, autodisable injection devices when delivered by lay health workers.

scientific article published on 29 June 2013

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

scientific article

The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome

scientific article published on 01 July 2020

The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain

scientific article

The presynaptic CaV2.2 channel-transmitter release site core complex

scientific article

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

scientific article published on 01 February 2020

The role of cyclin dependent kinase 5 (Cdk5) in neuropathic pain

scientific article published on 05 August 2020

The transmitter release-site CaV2.2 channel cluster is linked to an endocytosis coat protein complex.

scientific article published in August 2007

Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.

scientific article published on 10 August 2015

Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents

scientific article published on 14 August 2017

Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER.

scientific article published on 25 May 2004

Transmitter release face Ca2+ channel clusters persist at isolated presynaptic terminals

scientific article published on 01 March 2006

Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?

scientific article published in April 2018

VOLTAGE-GATED CALCIUM CHANNELS ARE NOT AFFECTED BY THE NOVEL ANTI-EPILEPTIC DRUG LACOSAMIDE.

scientific article

Validating indicators of CNS disorders in a swine model of neurological disease

Validating indicators of CNS disorders in a swine model of neurological disease

scientific article published on 19 February 2020

Voltage sensor mutations differentially target misfolded K+ channel subunits to proteasomal and non-proteasomal disposal pathways.

scientific article

hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation

scientific article published on 01 May 1999

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