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List of works by Robert Schierwagen

"Tipping" extracellular matrix remodeling towards regression of liver fibrosis: novel concepts

scientific article

Activation of the MAS receptor by angiotensin-(1-7) in the renin-angiotensin system mediates mesenteric vasodilatation in cirrhosis.

scientific article published on 22 June 2013

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

scientific article published on 6 May 2014

Assessment of response to beta-blockers by expression of βArr2 and RhoA/ROCK2 in antrum mucosa in cirrhotic patients.

scientific article published on 28 January 2016

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats

scientific article published on 13 August 2012

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

scientific article published on 26 October 2020

Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties.

scientific article published in January 2018

Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality.

scientific article published on 6 November 2017

Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS.

scientific article

Circulating miRNA-122 levels are associated with hepatic necroinflammation and portal hypertension in HIV/HCV coinfection

scientific article

Circulating microbiome in blood of different circulatory compartments

article

Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis

scientific article published on 12 June 2019

Combined antiretroviral therapy attenuates hepatic extracellular matrix remodeling in HIV patients assessed by novel protein fingerprint markers.

scientific article

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

scientific article published on 02 April 2020

Dynamic human liver proteome atlas reveals functional insights into disease pathways

scientific article published on 01 May 2022

Expression of vasoactive proteins in gastric antral mucosa reflects vascular dysfunction in patients with cirrhosis and portal hypertension.

scientific article

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

scientific article published on 16 September 2016

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.

scientific article

Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis

scientific article published on 25 September 2015

Hepatic inflammasome activation as origin of Interleukin-1α and Interleukin-1β in liver cirrhosis

scientific article published on 21 October 2020

Hepatic mitochondrial dysfunction in nonalcoholic steatohepatitis: Read-out or reason?

scientific article published on 18 March 2016

Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality.

scientific article

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.

scientific article

Liver Fibrosis in HIV Patients Receiving a Modern cART: Which Factors Play a Role?

scientific article published on December 2015

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis.

scientific article published on 11 January 2017

Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development

scientific article published on 28 August 2020

Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension.

scientific article

Novel Rat Model of Repetitive Portal Venous Embolization Mimicking Human Non-Cirrhotic Idiopathic Portal Hypertension.

scientific article

PRO-C3-levels in patients with HIV/HCV-Co-infection reflect fibrosis stage and degree of portal hypertension

scientific article

Quantitative liver MRI including extracellular volume fraction for non-invasive quantification of liver fibrosis: a prospective proof-of-concept study.

scientific article

Rationale for the use of statins in liver disease.

scientific article published on 9 March 2017

Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties.

scientific article published on 17 June 2017

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

scientific article published on 19 February 2019

Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts

scientific article published on 8 March 2011

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

scientific article published on 17 April 2020

Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats.

scientific article published on 30 July 2013

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

scientific article published on 11 August 2015

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

scientific article published on 07 May 2020

Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.

scientific article published on 28 September 2015

Statins as a Therapy of Chronic Liver Disease?

scientific article

Statins improve NASH via inhibition of RhoA and Ras.

scientific article published on 15 September 2016

Statins, Rho GTPases and KLF2: new mechanistic insight into liver fibrosis and portal hypertension

scientific article published on 16 January 2015

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor

scientific article published on 12 August 2019

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury

scientific article published on 29 June 2016

The role of miRNA-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS.

scientific article

Trust is good, control is better: technical considerations in blood microbiome analysis

scientific article published on 15 June 2019

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection

scientific article

β-Arrestin2 is increased in liver fibrosis in humans and rodents

scientific article published on 01 November 2020

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