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List of works by E Sousa

1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity

scientific article published on 04 June 2019

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry

scientific article published on 17 March 2016

A Century of Thioxanthones: Through Synthesis and Biological Applications

scientific article published on January 1, 2013

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.

scientific article published on 19 November 2016

An antifouling model from the sea: a review of 25 years of zosteric acid studies.

scientific article published on 24 November 2017

Anthraquinones, Diphenyl Ethers, and Their Derivatives from the Culture of the Marine Sponge-Associated Fungus Neosartorya spinosa KUFA 1047

scientific article published in 2021

Anticancer and cancer preventive compounds from edible marine organisms

scientific article published on 6 April 2017

Antifouling potential of Nature-inspired sulfated compounds.

scientific article published on 13 February 2017

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

scientific article published on 19 January 2011

Antithrombotics from the Sea: Polysaccharides and Beyond

scientific article published on 16 March 2019

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

scientific article published on 31 July 2018

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease

scientific article published on 19 March 2019

BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections

scientific article published on 08 May 2022

Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

scientific article published on 21 September 2020

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

scientific article published on 28 December 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

scientific article published on 30 June 2018

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Bromoalkoxyxanthones as promising antitumor agents: synthesis, crystal structure and effect on human tumor cell lines.

scientific article

Chemistry of the fumiquinazolines and structurally related alkaloids

scientific article published on 09 August 2018

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.

scientific article published on 10 March 2018

Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents

scientific article published on 28 December 2023

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives

scientific article

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate

scientific article (publication date: 2013)

Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations

article

Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach

scientific article published on February 18, 2013

Dual anticoagulant/antiplatelet persulfated small molecules

scientific article published on 15 March 2011

Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.

scientific article

Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging

scientific article published on 16 June 2020

Emerging sulfated flavonoids and other polyphenols as drugs: nature as an inspiration.

scientific article published on 28 March 2013

Evolution of the use of antioxidants in anti-ageing cosmetics

scientific article published on 01 August 2019

Flavonoids with an oligopolysulfated moiety: a new class of anticoagulant agents.

scientific article published on 7 December 2010

From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

scientific article published in 2021

From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents

scientific article published on 13 November 2021

Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

scientific article published on 27 August 2019

Immobilized imidazolium-based ionic liquids in C18 for solid-phase extraction

scientific article published on 19 February 2020

Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat

scientific article published on 25 January 2014

Inhibition of protein kinase C by synthetic xanthone derivatives.

scientific article published in April 2003

Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone.

scientific article

Lichen Xanthones as Models for New Antifungal Agents

scientific article published on 12 October 2018

Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.

scientific article published on 23 March 2018

Marine Natural Products as Models to Circumvent Multidrug Resistance

scientific article

Marine-Derived Compounds and Prospects for Their Antifungal Application

scientific article published on 11 December 2020

Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics

scientific article published on 29 May 2020

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.

scientific article published on 15 June 2016

Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.

scientific article published on 9 February 2018

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

scientific article published in 2021

Microbial interaction between a CTXM-15 -producing Escherichia coli and a susceptible Pseudomonas aeruginosa isolated from bronchoalveolar lavage: influence of cefotaxime in the dual-species biofilm formation

scientific article published on 9 March 2015

Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells.

scientific article published on 10 October 2016

Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay.

scientific article published on 6 December 2016

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy

scientific article published on 14 September 2016

New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated C28 Steroid and Azaphilone from the Culture Extract of a Marine Sponge-Associated Fungus, Talaromyces pinophilus KUFA 1767

scientific article published in 2023

New Uses for Old Drugs: Pharmacophore‐Based Screening for the Discovery of P‐Glycoprotein Inhibitors

scientific article published on March 29, 2011

New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines

scientific article published on 31 December 2013

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

scientific article published on 19 January 2019

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

scientific article published on 21 August 2020

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies

scientific article published on 15 February 2019

Old Drugs as New Treatments for Neurodegenerative Diseases

scientific article published on 11 May 2018

Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines

scientific article published on 21 April 2019

One Step Forward towards the Development of Eco-Friendly Antifouling Coatings: Immobilization of a Sulfated Marine-Inspired Compound

scientific article published on 25 September 2020

Overcoming environmental problems of biocides: Synthetic bile acid derivatives as a sustainable alternative

scientific article published on 24 October 2019

P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies

scientific article published on 19 November 2019

P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.

scientific article

Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732

scientific article published in 2023

Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.

scientific article published on 18 July 2011

Potential benefits of a sulfated resveratrol derivative for topical application.

scientific article published on 27 March 2018

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

scientific article published on 25 June 2020

Prenylated phenylbutyrolactones from cultures of a marine sponge-associated fungus Aspergillus flavipes KUFA1152

scientific article published in 2021

Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.

scientific article

Quantification of a Sulfated Marine-Inspired Antifouling Compound in Several Aqueous Matrices: Biodegradation Studies and Leaching Assays from Polydimethylsiloxane Coatings

scientific article published in 2022

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis

scientific article published on 13 January 2016

Sources and Biological Activities of Marine Sulfated Steroids

scientific article published on 3 January 2018

Strategies to Overcome Heparins' Low Oral Bioavailability

scientific article

Structure and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective

scientific article published on January 1, 2012

Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase

scientific article

Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones

scientific article published on 30 July 2020

Structure-activity relationship studies for multitarget antithrombotic drugs

scientific article published on 15 November 2016

Sulfated small molecules targeting eBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA.

scientific article

Synergistic Effects Between Thioxanthones and Oxacillin Against Methicillin-Resistant Staphylococcus aureus.

scientific article published on 19 March 2015

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

scientific article published in October 2002

Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth

scientific article published on 05 May 2018

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

scientific article published on 01 February 2019

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

scientific article published on 22 May 2019

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization

scientific article published on 12 December 2018

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells

article

The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs

scientific article published on 10 April 2017

The network of P-glycoprotein and microRNAs interactions

scientific article published on 17 October 2013

Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

scientific article published on January 2012

Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone

scientific article

Xanthone derivatives: new insights in biological activities.

scientific article

Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.

scientific article published in December 2002

Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.

scientific article published on 29 March 2013