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List of works by Gaël Roué

4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies.

scientific article

A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response

scientific article published on 01 September 2004

A mouse model of disseminated mantle cell lymphoma highlights a lack of activity of estrogen receptor β agonists toward tumor burden

scientific article

Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma

scientific article published on 31 March 2017

Acute myeloid leukemia with NPM1 mutation and favorable European LeukemiaNet category: outcome after preemptive intervention based on measurable residual disease

scientific article published on 08 June 2020

AduPARE1A and gemcitabine combined treatment trigger synergistic antitumor effects in pancreatic cancer through NF-κB mediated uPAR activation.

scientific article published on 31 July 2015

Annonaceous acetogenins: the hydroxyl groups and THF rings are crucial structural elements for targeting the mitochondria, demonstration with the synthesis of fluorescent squamocin analogues.

scientific article published in June 2005

Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle cell lymphoma involves the destabilization of cyclin D1/p27KIP1 complexes

scientific article published on 31 October 2013

Autophagy controls everolimus (RAD001) activity in mantle cell lymphoma

scientific article published on 18 October 2012

B cell activation through CD40 and IL4R ligation modulates the response of chronic lymphocytic leukaemia cells to BAFF and APRIL.

scientific article

BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

scientific article published on 3 July 2008

BFL-1 expression determines the efficacy of venetoclax in MYC+/BCL2+ double hit lymphoma.

scientific article

Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199.

scientific article

Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling

scientific article

CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia.

scientific article

Caspase-independent type III PCD: a new means to modulate cell death in chronic lymphocytic leukemia

scientific article

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

scientific article published on 10 March 2009

Combined analysis of levels of serum B-cell activating factor and a proliferation-inducing ligand as predictor of disease progression in patients with chronic lymphocytic leukemia

scientific article

Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma

scientific article

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.

scientific article published on 24 October 2017

Daratumumab displays in vitro and in vivo anti-tumor activity in models of B-cell non-Hodgkin lymphoma and improves responses to standard chemo-immunotherapy regimens

scientific article published on 11 July 2019

Disruption of follicular dendritic cells-follicular lymphoma cross-talk by the pan-PI3K inhibitor BKM120 (Buparlisib).

scientific article published on 5 May 2014

Drp1 mediates caspase-independent type III cell death in normal and leukemic cells

scientific article published on 6 August 2007

Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma.

scientific article published on August 2014

Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma

scientific article published on 14 March 2017

Dysfunction of the Fas apoptotic signaling pathway in persistent polyclonal B-cell lymphocytosis.

scientific article published in February 2003

Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line.

scientific article published on January 2001

Expression and subcellular localization of cyclin-dependent kinase inhibitor p27 does not correlate with proliferation pattern of mantle lymphoma cells

scientific article published on 6 February 2014

Expression of a truncated B lymphocyte-induced maturation protein-1 isoform is associated with an incomplete plasmacytic differentiation program in chronic lymphocytic leukemia

scientific article published on 2 June 2017

Expression of cyclins D-type in B-chronic lymphoproliferative disorders

scientific article published in July 2000

Expression of dengue ApoptoM sequence results in disruption of mitochondrial potential and caspase activation.

scientific article published on August 2003

Expression of the two alternative [a] and [b] transcripts of CCND1 gene in cyclin D1-expressing B-malignancies: relevance for the pathogenesis.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

scientific article published on 16 March 2010

In vivo intratumoral Epstein-Barr virus replication is associated with XBP1 activation and early-onset post-transplant lymphoproliferative disorders with prognostic implications.

scientific article published on 25 April 2014

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.

scientific article published on 21 October 2013

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma ⬇️

scientific article published on May 31, 2013

Loss of the Immune Checkpoint CD85j/LILRB1 on Malignant Plasma Cells Contributes to Immune Escape in Multiple Myeloma.

scientific article published on 12 March 2018

Management of Drug Resistance in Mantle Cell Lymphoma

scientific article published on 12 June 2020

Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release

scientific article published in August 2003

Pharmacological Targeting of BET Bromodomain Proteins in Acute Myeloid Leukemia and Malignant Lymphomas: From Molecular Characterization to Clinical Applications

scientific article published on 02 October 2019

Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma

scientific article published on 28 June 2018

Plasmablastic transformation of low-grade B-cell lymphomas: report on 6 cases

scientific article published in February 2013

Recent Advances in the Targeting of Epigenetic Regulators in B-Cell Non-Hodgkin Lymphoma

scientific article published on 16 October 2019

Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma

scientific article published on 01 January 2020

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma

scientific article published on 15 January 2013

Selective Inhibition of I B Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP Level

scientific article published on 01 February 2007

Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: selection and study of a benzoquinone hybrid with an improved biological profile.

scientific article published in January 2006

Sorafenib inhibits cell migration and stroma-mediated bortezomib resistance by interfering B-cell receptor signaling and protein translation in mantle cell lymphoma

scientific article published on 11 December 2012

Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells.

scientific article published on 20 December 2011

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma

scientific article published on February 2014

Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma

scientific article

Targeting the ubiquitin proteasome system: beyond proteasome inhibition.

scientific article published on January 2013

The BET bromodomain inhibitor CPI203 improves lenalidomide and dexamethasone activity in in vitro and in vivo models of multiple myeloma by blockade of Ikaros and MYC signaling.

scientific article

The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma.

scientific article published on 22 January 2018

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

scientific article published on 16 January 2007

The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-κB mutational status

scientific article published on 24 August 2017

The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma

scientific article

The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78

scientific article published on 24 November 2010

The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia.

scientific article published on 16 September 2016

The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma

scientific article

The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells

scientific article published on 12 July 2013

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

scientific article published on 15 September 2005

The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells

scientific article published on 30 April 2014

Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 10th annual conference of the European Mantle Cell Lymphoma Network

scientific article published on 18 August 2011

Upstream mediators of the Fas apoptotic transduction pathway are defective in B-chronic lymphocytic leukemia.

scientific article

Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters

scientific article published on 7 June 2011

ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1.

scientific article published on 13 December 2016

p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541.

scientific article

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