List of works - Giuseppe Battaglia

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

scientific article

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

scientific article published on 2 July 2015

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

scientific article published on 11 January 2011

Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus.

scientific article published on 27 January 2017

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

scientific article

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

scientific article

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

scientific article published on 12 August 2009

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

scientific article

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

scientific article

Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans.

scientific article published on June 2013

Antidepressant activity of fingolimod in mice.

scientific article published on 24 May 2015

Bilateral benign blepharoclonus

scientific article published on 05 February 2009

Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats.

scientific article published in January 2013

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

scientific article

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

scientific article published on 5 March 2015

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors ⬇️

scientific article published on February 6, 2012

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

scientific article published on 21 June 2016

Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex ⬇️

scientific article published on March 28, 2012

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

scientific article published on 7 May 2010

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

scientific article

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

scientific article published on 14 March 2017

Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism.

scientific article published on 6 June 2005

Dopamine stimulation via infusion in the lateral ventricle

scientific article published in August 2006

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

scientific article

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

scientific article

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

scientific article published on 31 August 2011

Early defect of transforming growth factor β1 formation in Huntington's disease.

scientific article published on March 2011

Early life stress causes refractoriness to haloperidol-induced catalepsy.

scientific article published on 28 May 2013

Effects of repeated low doses of MDMA on EEG activity and fluoro-jade B histochemistry.

scientific article published in October 2004

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

scientific article published in April 2003

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

scientific article published in January 2004

Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.

scientific article published in January 2005

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

scientific article published in August 2005

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

scientific article published on 12 April 2008

Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

scientific article

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

scientific article

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

scientific article published on 18 October 2002

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

scientific article published on 7 October 2011

Exposure to predator odor and resulting anxiety enhances the expression of the α2 δ subunit of voltage-sensitive calcium channels in the amygdala.

scientific article

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

scientific article

Fingolimod protects cultured cortical neurons against excitotoxic death

scientific article

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

scientific article published on 24 October 2017

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

scientific article published on 18 August 2017

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

scientific article published in March 2009

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease ⬇️

scientific article published on June 1, 2012

Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.

scientific article

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

scientific article published in March 2005

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

scientific article

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

scientific article published in October 2008

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

scientific article published in April 2007

Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

scientific article published in February 2010

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

scientific article published on July 2006

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

scientific article published on 4 February 2013

Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons ⬇️

scientific article published on September 18, 2012

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

scientific article published on 25 July 2010

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.

scientific article

Metabotropic glutamate receptors as drug targets: what's new?

scientific article published on 12 December 2014

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

scientific article published on 25 January 2012

Metabotropic glutamate receptors in the basal ganglia motor circuit

scientific article

Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy.

scientific article

Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons

scientific article published on 4 January 2008

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

scientific article published on 24 July 2007

Metabotropic glutamate receptors: new targets for the control of tumor growth?

scientific article published on 11 April 2007

Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.

scientific article published in January 2004

Microradiosurgical cortical transections generated by synchrotron radiation.

scientific article

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

scientific article published on 7 August 2015

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

scientific article

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

scientific article published on 23 October 2012

N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy

scientific article published on 01 January 2020

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

scientific article

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

scientific article published on 06 April 2011

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article published on 11 April 2017

Optimizing levodopa pharmacokinetics in Parkinson's disease: the role of COMT inhibitor.

scientific article published in October 2003

PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.

scientific article published in November 2004

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

scientific article

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

scientific article published on 13 September 2017

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

scientific article published on 29 December 2006

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

scientific article

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

scientific article published in July 2006

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

scientific article published on July 2005

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

scientific article published on 19 November 2013

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.

scientific article

Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings

scientific article published on 3 July 2008

Protection by apomorphine in two independent models of acute inhibition of oxidative metabolism in rodents

scientific article published in April 2006

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

scientific article

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

scientific article published on 26 January 2011

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

scientific article published on August 2003

Quantitative 3D investigation of Neuronal network in mouse spinal cord model.

scientific article published on 23 January 2017

Rat sensorimotor cortex tolerance to parallel transections induced by synchrotron-generated X-ray microbeams

scientific article published on 30 October 2017

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice

scientific article

Similarities between methamphetamine toxicity and proteasome inhibition.

scientific article published in October 2004

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

scientific article

Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II

scientific article published on 01 November 2000

Stabbing headache in patients with autoimmune disorders.

scientific article published on 12 January 2012

Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

scientific article published on 8 July 2008

Synchrotron-generated microbeam sensorimotor cortex transections induce seizure control without disruption of neurological functions

scientific article

Synchrotron-generated microbeams induce hippocampal transections in rats

scientific article published on 9 January 2018

Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis

scientific article

TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.

scientific article

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

scientific article

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

scientific article published on 15 December 2010

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

scientific article published on 24 October 2015

The HIV-1 viral protein Tat increases glutamate and decreases GABA exocytosis from human and mouse neocortical nerve endings.

scientific article published on 24 December 2009

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

scientific article published on 22 April 2008

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases.

scientific article published on January 2011

The conditioned eyeblink reflex: a potential tool for the detection of cerebellar dysfunction in multiple sclerosis.

scientific article published on 25 May 2011

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

scientific article published on 29 April 2016

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

scientific article published on 01 August 2007

The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?

scientific article published on 8 March 2017

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

scientific article published on 11 January 2010

Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders.

scientific article

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

scientific article published on 23 December 2015

Type-3 metabotropic glutamate receptors negatively modulate bone morphogenetic protein receptor signaling and support the tumourigenic potential of glioma-initiating cells.

scientific article

Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas ⬇️

scientific article published on November 23, 2012

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling.

scientific article

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

scientific article

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

scientific article

mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at Schaffer collateral-CA1 synapses mediates metaplasticity

scientific article published on September 2014

List of works by Giuseppe Battaglia

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus.

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans.

Antidepressant activity of fingolimod in mice.

Bilateral benign blepharoclonus

Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats.

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors ⬇️

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex ⬇️

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism.

Dopamine stimulation via infusion in the lateral ventricle

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

Early defect of transforming growth factor β1 formation in Huntington's disease.

Early life stress causes refractoriness to haloperidol-induced catalepsy.

Effects of repeated low doses of MDMA on EEG activity and fluoro-jade B histochemistry.

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

Exposure to predator odor and resulting anxiety enhances the expression of the α2 δ subunit of voltage-sensitive calcium channels in the amygdala.

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

Fingolimod protects cultured cortical neurons against excitotoxic death

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease ⬇️

Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons ⬇️

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.

Metabotropic glutamate receptors as drug targets: what's new?

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

Metabotropic glutamate receptors in the basal ganglia motor circuit

Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy.

Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

Metabotropic glutamate receptors: new targets for the control of tumor growth?

Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.

Microradiosurgical cortical transections generated by synchrotron radiation.

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

Optimizing levodopa pharmacokinetics in Parkinson's disease: the role of COMT inhibitor.

PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.