List of works by Lubka T. Roumenina

1st EFIS-EJI intensive course in clinical immunology: towards a new era in immunology

scientific article published on 01 February 2011

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

scientific article published on 29 November 2018

A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF-binding site distant from its epitope.

scientific article published on 30 March 2010

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

scientific article published on 17 July 2017

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

scientific article

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies

scientific article published on 28 March 2012

Alternative complement pathway assessment in patients with atypical HUS.

scientific article

Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN.

scientific article published on 17 January 2017

Anti-factor H autoantibodies assay

scientific article

Anti-factor H autoantibodies in C3 glomerulopathies and in atypical hemolytic uremic syndrome: one target, two diseases

scientific article

Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

scientific article published on 10 May 2019

Antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions

scientific article published on 18 July 2007

Antibody polyreactivity in health and disease: statu variabilis

scientific article published on August 2013

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

scientific article published on 15 December 2016

Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes

scientific article

Atypical hemolytic-uremic syndrome related to abnormalities within the complement system

scientific article

Autoantibodies Against C3b-Functional Consequences and Disease Relevance

scientific article published on 29 January 2019

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis

scientific article published in 2022

B cells and complement at the forefront of chemotherapy

scientific article published on 05 May 2020

Both Monoclonal and Polyclonal Immunoglobulin Contingents Mediate Complement Activation in Monoclonal Gammopathy Associated-C3 Glomerulopathy

scientific article published on 02 October 2018

C1q and its growing family.

scientific article

C3dg-CR3 interaction in erythrophagocytosis.

scientific article

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies

scientific article published on 14 July 2017

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis.

scientific article published in March 2018

Complement C1q-target proteins recognition is inhibited by electric moment effectors.

scientific article published in September 2007

Complement System: Promoter or Suppressor of Cancer Progression?

scientific article published on 25 October 2020

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

scientific article

Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions

scientific article published on 22 February 2019

Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy

scientific article published on 28 January 2020

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

scientific article published on 09 November 2010

Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?

scientific article

Context-dependent roles of complement in cancer

scientific article published on 30 October 2019

Correction to Mechanism and Functional Implications of the Heme-Induced Binding Promiscuity of IgE

scientific article published on 03 April 2015

Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology

scientific article published on 01 January 2019

Distal Angiopathy and Atypical Hemolytic Uremic Syndrome: Clinical and Functional Properties of an Anti-Factor H IgAλ Antibody

scientific article

Eculizumab in an anephric patient with atypical haemolytic uraemic syndrome and advanced vascular lesions

scientific article

Endothelial cells: source, barrier, and target of defensive mediators

scientific article

Endothelium structure and function in kidney health and disease

scientific article published on 01 February 2019

Existence of Different but Overlapping IgG- and IgM-Binding Sites on the Globular Domain of Human C1q†

scientific article published in August 2006

Functional Characterization of Autoantibodies against Complement Component C3 in Patients with Lupus Nephritis.

scientific article

Functional and structural insight into properdin control of complement alternative pathway amplification.

scientific article published on 6 March 2017

Functional complement C1q abnormality leads to impaired immune complexes and apoptotic cell clearance

scientific article

Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS).

scientific article

Genetics of hemolytic uremic syndromes

scientific article

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

scientific article published on 20 December 2018

Heme interacts with c1q and inhibits the classical complement pathway

scientific article

Heme-Exposed Pooled Therapeutic IgG Improves Endotoxemia Survival.

scientific article

Heme: Modulator of Plasma Systems in Hemolytic Diseases

scientific article published on 11 February 2016

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H

scientific article published on 17 December 2018

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

scientific article

Identification of a major linear C1q epitope allows detection of systemic lupus erythematosus anti-C1q antibodies by a specific peptide-based enzyme-linked immunosorbent assay

scientific article published on 01 November 2012

Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains

scientific article published on April 2006

Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide.

scientific article published on 10 May 2008

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

scientific article published on 21 June 2018

Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes.

scientific article published on 14 December 2015

Iron ions and haeme modulate the binding properties of complement subcomponent C1q and of immunoglobulins

scientific article published on 01 March 2007

Kinetics and thermodynamics of interaction of coagulation factor VIII with a pathogenic human antibody

scientific article published on 6 October 2009

Loss of DGKε induces endothelial cell activation and death independently of complement activation

scientific article published on 10 December 2014

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

scientific article

Mechanism and functional implications of the heme-induced binding promiscuity of IgE.

scientific article

Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction.

scientific article published on April 2004

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort

scientific article (publication date: March 2011)

Overall neutralization of complement factor H by autoantibodies in the acute phase of the autoimmune form of atypical hemolytic uremic syndrome

scientific article

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

scientific article published on 08 March 2019

Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations

scientific article

Role of Ca2+in the Electrostatic Stability and the Functional Activity of the Globular Domain of Human C1q†

scientific article published on 01 November 2005

Site-specific N-glycosylation analysis of soluble Fcγ receptor IIIb in human serum.

scientific article published on 9 February 2018

The complement system: a double edge sword in tumor progression

scientific article published on 10 October 2017

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

scientific article published on 6 September 2013

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

scientific article published on 04 June 2019

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

scientific article

Von Willebrand Factor Interacts with Surface-Bound C1q and Induces Platelet Rolling.

scientific article published on 3 October 2016