List of works - Axel T. Brunger

Version 1.2 of the Crystallography and NMR system

scientific article (publication date: 2007)

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

scientific article

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

scientific article

Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2.

scientific article published in April 1988

Super-resolution biomolecular crystallography with low-resolution data

scientific article (publication date: 22 April 2010)

A new generation of crystallographic validation tools for the protein data bank

scientific article

Transglutaminase 2 undergoes a large conformational change upon activation

scientific article published in December 2007

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

scientific article

A dimerization motif for transmembrane α–helices

scientific article published on 01 March 1994

Structural Changes Are Associated with SolubleN-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

scientific article published in Journal of Biological Chemistry

Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

scientific article published in October 1994

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

scientific article (publication date: October 2003)

Folding intermediates of SNARE complex assembly

scientific journal article

Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly

scientific journal article

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

scientific journal article

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

scientific article

Polar residues drive association of polyleucine transmembrane helices

scholarly article

Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation.

scientific article published in January 1997

Substrate recognition strategy for botulinum neurotoxin serotype A.

scientific article

Structure and function of SNARE and SNARE-interacting proteins

scientific article

New parameters for the refinement of nucleic acid-containing structures

scientific article

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

scientific article

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

scientific article

Crystallographic refinement by simulated annealing. Application to a 2.8 A resolution structure of aspartate aminotransferase

scientific article

Central pore residues mediate the p97/VCP activity required for ERAD

scientific article (publication date: 19 May 2006)

The 1.0 A crystal structure of Ca(2+)-bound calmodulin: an analysis of disorder and implications for functionally relevant plasticity

scientific article

Combining efficient conformational sampling with a deformable elastic network model facilitates structure refinement at low resolution

scientific article

Free R value: cross-validation in crystallography

scientific article published on 01 January 1997

Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition

scientific article

Interhelical hydrogen bonding drives strong interactions in membrane proteins

scientific article published on 01 February 2000

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

scientific article

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

scientific article published on 01 February 1995

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

scientific article

Properties of native brain α-synuclein

scientific article

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis

scientific article

Mechanistic insights into the recycling machine of the SNARE complex

scientific article

Three-dimensional structure of proteins determined by molecular dynamics with interproton distance restraints: application to crambin

scientific article published on June 1986

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

scientific article (publication date: December 2002)

Nucleotide dependent motion and mechanism of action of p97/VCP

scientific article (publication date: 25 March 2005)

Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complex

scientific article

Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZ

scientific article

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

scientific article

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions

scientific article

Active site dynamics in protein molecules: a stochastic boundary molecular-dynamics approach

scientific article published in May 1985

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

scientific article

Statistical analysis of predicted transmembrane alpha-helices

scientific article published in December 1998

Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95

scientific article

A Structural Change Occurs upon Binding of Syntaxin to SNAP-25

scientific article published in Journal of Biological Chemistry

Single molecule observation of liposome-bilayer fusion thermally induced by soluble N-ethyl maleimide sensitive-factor attachment protein receptors (SNAREs)

scientific article

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

scientific article

List of works by Axel T. Brunger

Version 1.2 of the Crystallography and NMR system

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2.

Super-resolution biomolecular crystallography with low-resolution data

A new generation of crystallographic validation tools for the protein data bank

Transglutaminase 2 undergoes a large conformational change upon activation

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

A dimerization motif for transmembrane α–helices

Structural Changes Are Associated with SolubleN-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

Folding intermediates of SNARE complex assembly

Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

Polar residues drive association of polyleucine transmembrane helices

Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation.

Substrate recognition strategy for botulinum neurotoxin serotype A.

Structure and function of SNARE and SNARE-interacting proteins

New parameters for the refinement of nucleic acid-containing structures

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

Crystallographic refinement by simulated annealing. Application to a 2.8 A resolution structure of aspartate aminotransferase

Central pore residues mediate the p97/VCP activity required for ERAD

The 1.0 A crystal structure of Ca(2+)-bound calmodulin: an analysis of disorder and implications for functionally relevant plasticity

Combining efficient conformational sampling with a deformable elastic network model facilitates structure refinement at low resolution

Free R value: cross-validation in crystallography

Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition

Interhelical hydrogen bonding drives strong interactions in membrane proteins

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

Properties of native brain α-synuclein

Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis

Mechanistic insights into the recycling machine of the SNARE complex

Three-dimensional structure of proteins determined by molecular dynamics with interproton distance restraints: application to crambin

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

Nucleotide dependent motion and mechanism of action of p97/VCP

Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complex

Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZ

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions

Active site dynamics in protein molecules: a stochastic boundary molecular-dynamics approach

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

Statistical analysis of predicted transmembrane alpha-helices

Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95

A Structural Change Occurs upon Binding of Syntaxin to SNAP-25

Single molecule observation of liposome-bilayer fusion thermally induced by soluble N-ethyl maleimide sensitive-factor attachment protein receptors (SNAREs)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2