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List of works by Stina Syvänen

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

scientific article published on 28 May 2014

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

scientific article

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

scientific article published on 6 January 2017

A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements

scientific article

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

scientific article

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

scientific article published on 31 May 2018

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

scientific article published on 19 February 2016

Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

scientific article published on 2 January 2018

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.

scientific article published on January 2017

Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy

scientific article published on 07 September 2018

Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data

scientific article

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting.

scientific article published on 12 October 2016

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

scientific article published on 02 June 2021

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment.

scientific article published on 14 September 2017

Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease

scientific article published on 06 November 2019

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.

scientific article

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

scientific article published on 20 July 2006

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.

scientific article published on 15 September 2017

Engineered antibodies: new possibilities for brain PET?

scientific article published on 24 July 2019

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

scientific article published on 01 January 2021

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

scientific article published on 25 November 2020

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

scientific article published in 2022

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

scientific article published on 06 October 2018

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

scientific article published on 03 January 2021

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

scientific article published on 01 January 2019

On the rate and extent of drug delivery to the brain.

scientific article published on 05 December 2007

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

scientific article published on 23 August 2018

Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

scientific article published on 7 April 2006

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography

scientific article

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β.

scientific article published on 8 December 2017

Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

scientific article published on 8 August 2006

Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

scientific article

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer's disease

scientific article published on 21 September 2020

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

scientific article published on 14 May 2011

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

scientific article

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

scientific article published in January 2013

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

scientific article published on 5 January 2012

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

scientific article published on 21 September 2018

Synthesis of two potential NK1-receptor ligands using [1-11C]ethyl iodide and [1-11C]propyl iodide and initial PET-imaging

scientific article

Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.

scientific article published on January 2010

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

scientific article published on 25 June 2021

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

scientific article

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

scientific article published on 2 July 2012

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness

scientific article

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