List of works - Andrey Y. Abramov

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'.

scientific article published on 26 May 2016

A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses

scientific article published on April 2015

A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia

scientific article

Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells

scientific article published on February 2003

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

scientific article published on 16 July 2015

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

scientific article published on 12 November 2015

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

scientific article

Antibodies to synthetic fragment 95-123 of the prion protein protect neurons and astrocytes from beta-amyloid toxicity

scientific article published in March 2013

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

scientific journal article

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

scientific article

Bioenergetic consequences of PINK1 mutations in Parkinson disease

scientific article

Ca2+ is a key factor in α-synuclein-induced neurotoxicity

scientific article published on 17 March 2016

Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

scientific article

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease ⬇️

scientific article published on December 15, 2011

Cellular mechanisms of complex I-associated pathology

scientific article published on 01 December 2019

Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration

scientific article

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

scientific article published on 08 December 2008

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data

scientific article

Direct observation of the interconversion of normal and toxic forms of α-synuclein

scientific article

Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease

scientific article

Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase

scientific article published on 14 June 2010

Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells.

scientific article published on 15 February 2014

Energy depletion in seizures: anaplerosis as a strategy for future therapies

scientific article published on 30 May 2012

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease

scientific article

Expression and modulation of an NADPH oxidase in mammalian astrocytes.

scientific article published on October 2005

Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity ⬇️

scientific article published on March 10, 2011

Functional Oxygen Sensitivity of Astrocytes.

scientific article published in July 2015

Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity.

scientific article published on 20 January 2013

High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach

scientific article published on 22 January 2008

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.

scientific article

Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function

scientific article

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism

scientific article

Immunization with either prion protein fragment 95-123 or the fragment-specific antibodies rescue memory loss and neurodegenerative phenotype of neurons in olfactory bulbectomized mice

scientific article

Impact of fumonisin B1 on glutamate toxicity and low magnesium-induced seizure activity in neuronal primary culture

scientific article

Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons

scientific article published on 17 August 2009

In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8.

scientific article published on 18 July 2014

Inorganic polyphosphate and energy metabolism in mammalian cells

scientific article

Inorganic polyphosphate regulates AMPA and NMDA receptors and protects against glutamate excitotoxicity via activation of P2Y receptors

scientific article published on 30 May 2019

Interaction of neurons and astrocytes underlies the mechanism of Aβ-induced neurotoxicity.

scientific article

Intracellular pH Modulates Autophagy and Mitophagy.

scientific article published on 18 February 2016

Ionophoretic properties of ferutinin ⬇️

scientific article published on October 1, 1997

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

scientific article published on 16 February 2016

Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?

scientific article

Lipid peroxidation is essential for phospholipase C activity and the inositol-trisphosphate-related Ca²⁺ signal.

scientific article published on 6 November 2013

Lipid peroxidation is essential for α-synuclein-induced cell death

scientific article published on March 2015

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

scientific article

Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes

scientific article

Measurement of mitochondrial NADH and FAD autofluorescence in live cells.

scientific article

Measurements of Threshold of Mitochondrial Permeability Transition Pore Opening in Intact and Permeabilized Cells by Flash Photolysis of Caged Calcium ⬇️

scientific article published on January 1, 2011

Mechanism of Oxidative Stress in Neurodegeneration ⬇️

scientific article published on May 16, 2012

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

scientific article

Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity

scientific article published on 24 February 2011

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

scientific article published on 18 April 2008

Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells

scientific article published on 17 May 2013

Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells

scientific article published on 4 May 2016

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease

scientific article published on 11 April 2011

Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide

scientific article published on 25 August 2012

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

scientific article published on 13 July 2020

Mitochondrial Ca(2+) in neurodegenerative disorders.

scientific article published on 23 May 2015

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

scientific article published on 21 September 2020

Modulation of Intracellular Ca2+ Concentration by Vitamin B12 in Rat Thymocytes ⬇️

scientific article published on September 1, 2001

Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins.

scientific article published on 19 September 2013

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

scientific article published on October 2016

Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis

scientific article

Mutations in HPCA cause autosomal-recessive primary isolated dystonia

scientific article

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons

scientific article

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.

scientific article published on 17 October 2015

Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy

scientific article

Novel pathway for an old neurotransmitter: Dopamine-induced neuronal calcium signalling via receptor-independent mechanisms ⬇️

scientific article published on August 1, 2010

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

scientific article published on 14 January 2016

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

scientific article

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

scientific article published on 20 June 2013

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

scientific article published on 5 December 2014

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

scientific article

PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice

scientific article published on 7 May 2014

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

scientific article

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

scientific article published on March 2009

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

scientific article published on 29 September 2015

Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels

scientific article

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

scientific article published on 14 July 2018

Phospholipase iPLA<sub>2</sub>β averts ferroptosis by eliminating a redox lipid death signal

scientific article published on 04 February 2021

Polyhydroxybutyrate targets mammalian mitochondria and increases permeability of plasmalemmal and mitochondrial membranes.

scientific article

Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death

scientific article published on 10 February 2012

Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage

scientific article published on 09 April 2014

Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.

scientific article published in July 2008

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.

scientific article published on 3 May 2019

Role of inorganic polyphosphate in mammalian cells: from signal transduction and mitochondrial metabolism to cell death

scientific article published on February 2016

Role of polyhydroxybutyrate in mitochondrial calcium uptake

scientific article published on 20 May 2013

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

scientific article

Signalling properties of inorganic polyphosphate in the mammalian brain ⬇️

scientific article published on January 1, 2013

Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective

scientific article

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

scientific article published on 8 April 2015

Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death

scholarly article

Targeting mitochondrial dysfunction in neurodegenerative disease: Part I.

scientific article published on April 2010

Targeting mitochondrial dysfunction in neurodegenerative disease: Part II.

scientific article published on May 2010

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

scientific article

The emerging role of Nrf2 in mitochondrial function

scientific article published on 11 May 2015

The large-conductance Ca2+-activated K+ channel is essential for innate immunity

scientific article

The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides

scientific article

The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.

scientific article published on January 2013

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

scientific article

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation.

scientific article

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress

scientific article published on March 2004

Variability of mitochondrial energy balance across brain regions

scientific article published on 15 November 2020

List of works by Andrey Y. Abramov

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'.

A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses

A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia

Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

Antibodies to synthetic fragment 95-123 of the prion protein protect neurons and astrocytes from beta-amyloid toxicity

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

Bioenergetic consequences of PINK1 mutations in Parkinson disease

Ca2+ is a key factor in α-synuclein-induced neurotoxicity

Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease ⬇️

Cellular mechanisms of complex I-associated pathology

Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data

Direct observation of the interconversion of normal and toxic forms of α-synuclein

Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease

Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase

Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells.

Energy depletion in seizures: anaplerosis as a strategy for future therapies

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease

Expression and modulation of an NADPH oxidase in mammalian astrocytes.

Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis—Implication to mechanism of cell toxicity ⬇️

Functional Oxygen Sensitivity of Astrocytes.

Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity.

High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.

Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism

Immunization with either prion protein fragment 95-123 or the fragment-specific antibodies rescue memory loss and neurodegenerative phenotype of neurons in olfactory bulbectomized mice

Impact of fumonisin B1 on glutamate toxicity and low magnesium-induced seizure activity in neuronal primary culture

Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons

In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8.

Inorganic polyphosphate and energy metabolism in mammalian cells

Inorganic polyphosphate regulates AMPA and NMDA receptors and protects against glutamate excitotoxicity via activation of P2Y receptors

Interaction of neurons and astrocytes underlies the mechanism of Aβ-induced neurotoxicity.

Intracellular pH Modulates Autophagy and Mitophagy.

Ionophoretic properties of ferutinin ⬇️

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?

Lipid peroxidation is essential for phospholipase C activity and the inositol-trisphosphate-related Ca²⁺ signal.

Lipid peroxidation is essential for α-synuclein-induced cell death

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes

Measurement of mitochondrial NADH and FAD autofluorescence in live cells.

Measurements of Threshold of Mitochondrial Permeability Transition Pore Opening in Intact and Permeabilized Cells by Flash Photolysis of Caged Calcium ⬇️

Mechanism of Oxidative Stress in Neurodegeneration ⬇️

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells

Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease

Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

Mitochondrial Ca(2+) in neurodegenerative disorders.

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

Modulation of Intracellular Ca2+ Concentration by Vitamin B12 in Rat Thymocytes ⬇️

Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins.

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis

Mutations in HPCA cause autosomal-recessive primary isolated dystonia

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.

Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy

Novel pathway for an old neurotransmitter: Dopamine-induced neuronal calcium signalling via receptor-independent mechanisms ⬇️

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels