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List of works by Volker M. Lauschke

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

scientific article published in 2021

A 3D Cell Culture Model Identifies Wnt/β-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration

scientific article published on 23 June 2020

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

scientific article

An optimized prediction framework to assess the functional impact of pharmacogenetic variants

scientific article published on 12 September 2018

Author Correction: Liver macrophages regulate systemic metabolism through non-inflammatory factors

scientific article published on 01 April 2019

CYP2C19 and CYP2D6 Genotypes and Metabolizer Status Distribution in a Bulgarian Psychiatric Cohort

scientific article published in 2022

CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma

scientific article published on 01 October 2019

Calcium Signaling in Liver Injury and Regeneration

scientific article published on 04 July 2018

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

scientific article

Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study

scientific article published on 10 January 2018

Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews

scientific article published on 03 July 2018

Current Statistical Metrics Are Pragmatic Measures to Compare the Predictive Quality of Preclinical Assays

scientific article published on 01 September 2018

Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing

scientific article published on 12 June 2019

Documentation of clinically relevant genomic biomarker allele frequencies in the next-generation FINDbase worldwide database

scientific article published on 05 April 2020

Dysregulation of miR-223 constitutes a promising biomarker that informs about clinical outcomes of acute liver failure

scientific article published on 19 July 2017

Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation

scientific article published on 05 March 2020

Ethnogeographic and inter-individual variability of human ABC transporters

scientific article published on 23 March 2020

Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe

scientific article published on 29 July 2019

Functional characterization of CYP2D7 gene variants

scientific article published on 24 July 2018

Genetic Variant <i>ABCC1</i> rs45511401 Is Associated with Increased Response to Statins in Patients with Familial Hypercholesterolemia

scientific article published on 27 April 2022

Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response

scientific article published on 20 January 2020

Genetic variability and population diversity of the human SLCO (OATP) transporter family

article

Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records

scientific article published on 12 November 2018

Genetic variation in the human cytochrome P450 supergene family

scientific article published on 3 September 2015

Germline variant burden in multidrug resistance transporters is a therapy-specific predictor of survival in breast cancer patients

scientific article published on 17 February 2020

Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk

scholarly article by Yitian Zhou et al published October 2018 in Journal of Lipid Research

How to Consider Rare Genetic Variants in Personalized Drug Therapy

scientific article

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

scientific article published in Scientific Reports

Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions

article

In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na+-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1)

scientific article published on 10 March 2020

In vitro and ex vivo modeling of enteric bacterial infections

scientific article published on 28 December 2022

Integrating rare genetic variants into pharmacogenetic drug response predictions.

scientific article

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

scientific article published on 13 November 2020

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

scientific article published on 01 February 2020

Liver macrophages regulate systemic metabolism through non-inflammatory factors

scientific article published on 25 March 2019

Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation

scientific article published on 17 February 2021

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

scientific article published on 17 August 2016

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation.

scientific article published in February 2018

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

scientific article published on 23 September 2016

Organotypic and Microphysiological Models of Liver, Gut, and Kidney for Studies of Drug Metabolism, Pharmacokinetics, and Toxicity

scientific article published on 17 October 2019

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities

scientific article

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

scientific article published on 19 October 2015

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments

scientific article published on 27 November 2017

Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy.

scientific article

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier

scientific article published on 25 September 2020

Precision Medicine and Rare Genetic Variants

scientific article published on 17 December 2015

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.

scientific article

Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing

scientific article published on 23 January 2019

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

scientific article published on 01 September 2021

Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response

scientific article

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression

scientific article published on 29 April 2016

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

scientific article

The genetic landscape of the human solute carrier (SLC) transporter superfamily

scientific article published on 02 November 2019

The impact of variants in ATP-binding cassette transporters on breast cancer treatment

scientific article published on 23 November 2020

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

scientific article published on 30 January 2017

Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

scientific article published on 01 March 2018

Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

scientific article published on 16 October 2018

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

scientific article published on 5 April 2017

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