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List of works by Helen McIlleron

A Review of Moxifloxacin for the Treatment of Drug-Susceptible Tuberculosis

scientific article published on 24 July 2017

A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients.

scientific article published on 17 January 2012

A time-to-event pharmacodynamic model describing treatment response in patients with pulmonary tuberculosis using days to positivity in automated liquid mycobacterial culture

scientific article published on 26 November 2012

Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial

scientific article published on 5 October 2015

Arylacetamide deacetylase (AADAC) gene polymorphism and HIV infection affect the exposure of Rifapentine: a population pharmacokinetics analysis

article

Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study

scientific article

Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes.

scientific article published on July 2016

Chapter 19: Interactions between Antituberculosis and Antiretroviral Agents

article published in 2011

Clinical deterioration during antituberculosis treatment in Africa: incidence, causes and risk factors

scientific article

Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study

scientific article

Combined therapy for tuberculosis and HIV-1: the challenge for drug discovery

scientific article published on 27 September 2007

Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndrome

scientific article published on August 2007

Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis

scientific article

Determinants of rifampin, isoniazid, pyrazinamide, and ethambutol pharmacokinetics in a cohort of tuberculosis patients

scientific article

Determinants of virological outcome and adverse events in African children treated with paediatric nevirapine fixed-dose-combination tablets

scientific article published on 4 January 2017

Drug-drug interactions between bedaquiline and the antiretrovirals lopinavir/ritonavir and nevirapine in HIV-infected patients with drug-resistant TB.

scientific article

Effect of Isoniazid Intake on Ethionamide Pharmacokinetics and Target Attainment in Multidrug-Resistant Tuberculosis Patients

scientific article published on 26 July 2021

Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children

scientific article published on 31 August 2016

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.

scientific article

Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children

scientific article published on 05 October 2016

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis

scientific article published on 6 December 2017

Effect of rifampicin and efavirenz on moxifloxacin concentrations when co-administered in patients with drug-susceptible TB.

scientific article

Effect of rifampicin on efavirenz pharmacokinetics in HIV-infected children with tuberculosis

scientific article published in April 2009

Effect of rifampicin on lopinavir pharmacokinetics in HIV-infected children with tuberculosis

scientific article

Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis

scientific article published on 19 December 2007

Effects of four different meal types on the population pharmacokinetics of single-dose rifapentine in healthy male volunteers

scientific article

Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype

scientific article published on July 2013

Effects on the QT Interval of a Gatifloxacin-Containing Regimen versus Standard Treatment of Pulmonary Tuberculosis

scientific article

Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomised study.

scientific article

Elevated gatifloxacin and reduced rifampicin concentrations in a single-dose interaction study amongst healthy volunteers

scientific article

Erratum for Chirehwa et al., Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction

scientific article

Evaluation of an immunoassay for determination of plasma efavirenz concentrations in resource-limited settings

scientific article

Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations.

scientific article published on 17 June 2013

Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy

scientific article published on 4 August 2017

Global tuberculosis drug development pipeline: the need and the reality.

scientific article published on 18 May 2010

HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients

scientific article published on August 2016

High Prevalence of Subtherapeutic Plasma Concentrations of Efavirenz in Children

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis

scientific article

Impact of nonlinear interactions of pharmacokinetics and MICs on sputum bacillary kill rates as a marker of sterilizing effect in tuberculosis

scientific article

Isoniazid/acetylisoniazid urine concentrations: markers of adherence to isoniazid preventive therapy in children

scientific article published on May 2014

Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study

scientific article

Lipid-based nutrient supplements do not affect efavirenz but lower plasma nevirapine concentrations in Ethiopian adult HIV patients

scientific article published on 13 May 2015

Lopinavir exposure is insufficient in children given double doses of lopinavir/ritonavir during rifampicin-based treatment for tuberculosis

scientific article published in January 2011

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting

scientific article

Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review

scientific article

Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction

scientific article

Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin.

scientific article

Model-based evaluation of the pharmacokinetic differences between adults and children for lopinavir and ritonavir in combination with rifampicin

scientific article

Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients

scientific article

Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine

scientific article published on 14 May 2012

Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

scientific article published on 18 May 2021

Nevirapine concentrations in preterm and low birth weight HIV-exposed infants: implications for dosing recommendations

scientific article published in December 2014

Nutritional supplementation increases rifampin exposure among tuberculosis patients coinfected with HIV

scientific article

Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients

scientific article published on 24 October 2016

Paediatric use of second-line anti-tuberculosis agents: a review

scientific article

Pediatric tuberculous meningitis: Model-based approach to determining optimal doses of the anti-tuberculosis drugs rifampin and levofloxacin for children

scientific article published on 11 August 2015

Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa

scientific article published on 28 May 2015

Pharmacokinetics and Safety of Ofloxacin in Children with Drug-Resistant Tuberculosis.

scientific article

Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis.

scientific article

Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir

scientific article

Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania

scientific article

Pharmacokinetics of Pyrazinamide and Optimal Dosing Regimens for Drug-Sensitive and -Resistant Tuberculosis

scientific article published on 12 June 2017

Pharmacokinetics of Rifampin, Isoniazid, Pyrazinamide, and Ethambutol in Infants Dosed According to Revised WHO-Recommended Treatment Guidelines.

scientific article published on 25 January 2016

Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection

scientific article

Pharmacokinetics of lopinavir in HIV-infected adults receiving rifampin with adjusted doses of lopinavir-ritonavir tablets

scientific article

Pharmacokinetics of nevirapine in HIV-infected children under 3 years on rifampicin-based antituberculosis treatment

scientific article

Pharmacokinetics of ofloxacin and levofloxacin for prevention and treatment of multidrug-resistant tuberculosis in children.

scientific article published on 18 February 2014

Pharmacometrics: opportunity for reducing disease burden in the developing world: the case of Africa

scientific article published on 28 August 2013

Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations

scientific article

Plasma Efavirenz Exposure, Sex, and Age Predict Virological Response in HIV-Infected African Children

scientific article published on 21 April 2016

Plasma lopinavir concentrations predict virological failure in a cohort of South African children initiating a protease-inhibitor-based regimen

scientific article

Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis

scientific article published on 16 September 2015

Population Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Pregnant South African Women with Tuberculosis and HIV

scientific article published on 21 February 2020

Population Pharmacokinetics of Rifampin in Pregnant Women with Tuberculosis and HIV Coinfection in Soweto, South Africa

scientific article published on 7 December 2015

Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs

scientific article

Population pharmacokinetic model for adherence evaluation using lamivudine concentration monitoring

scientific article published in August 2012

Population pharmacokinetics and pharmacodynamics of ofloxacin in South African patients with multidrug-resistant tuberculosis

scientific article

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

scientific article published in November 2006

Population pharmacokinetics of cycloserine, and pharmacokinetic/pharmacodynamic target attainment, in MDR-tuberculosis patients dosed with terizidone

scientific article published on 17 August 2020

Population pharmacokinetics of ethambutol in South African tuberculosis patients.

scientific article

Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children.

scientific article published on January 2012

Population pharmacokinetics of lopinavir in combination with rifampicin-based antitubercular treatment in HIV-infected South African children.

scientific article

Population pharmacokinetics of nevirapine in combination with rifampicin-based short course chemotherapy in HIV- and tuberculosis-infected South African patients.

scientific article

Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses

scientific article published on 31 January 2014

Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption

scientific article published on 7 April 2008

Population pharmacokinetics of rifapentine and its primary desacetyl metabolite in South African tuberculosis patients.

scientific article

Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants

scientific article published on 16 April 2017

Principles for designing future regimens for multidrug-resistant tuberculosis.

scientific article published on 25 October 2013

Pyrazinamide plasma concentrations in young children with tuberculosis.

scientific article published in March 2011

Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

scientific article

Redefining multidrug-resistant tuberculosis based on clinical response to combination therapy

scientific article

Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines

scientific article

Reply to "breakpoints and drug exposure are inevitably closely linked"

scientific article

Requirements for the clinical evaluation of new anti-tuberculosis agents in children.

scientific article published in June 2013

Research capacity. Enabling the genomic revolution in Africa

scientific article published in June 2014

Rifampin levels, interferon-gamma release and outcome in complicated pulmonary tuberculosis

scientific article published on 24 September 2007

Rifampin pharmacokinetics in children, with and without human immunodeficiency virus infection, hospitalized for the management of severe forms of tuberculosis

scientific article

Serum drug concentrations predictive of pulmonary tuberculosis outcomes

scientific article published on 29 July 2013

Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment

scientific article

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial.

scientific article published on 19 April 2018

Special populations and pharmacogenetic issues in tuberculosis drug development and clinical research

scientific article

Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies

scientific article

Steady state pharmacokinetics of cycloserine in patients on terizidone for multidrug-resistant tuberculosis.

scientific article published in January 2018

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

scientific article

The early bactericidal activities of rifampin and rifapentine in pulmonary tuberculosis

scientific article

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

scientific article

The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children

scientific article published on 16 March 2016

The pharmacokinetics of lopinavir/ritonavir when given with isoniazid in South African HIV-infected individuals.

scientific article published on October 2015

The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals

scientific article

The pyrazinamide susceptibility breakpoint above which combination therapy fails

scientific article

The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy

scientific article

Towards early inclusion of children in tuberculosis drugs trials: a consensus statement

scientific article published on 6 May 2015

Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline Among Postpartum Women on Antiretroviral Therapy in South Africa

scientific article

Two-stage activity-safety study of daily rifapentine during intensive phase treatment of pulmonary tuberculosis

scientific article published on 01 July 2015

Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients

scientific article

Variability in the population pharmacokinetics of pyrazinamide in South African tuberculosis patients

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