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List of works by Peter J Little

(S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells

scientific article published on 27 March 2013

3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene

scientific article published on 01 January 1984

Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis

scientific article published on 01 August 2018

Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway.

scientific article

An Investigation of Sodium Fusidate and Recombinant Cytochrome P450 Enzymes Inhibition In-Vitro.

scientific article published on 6 June 2016

Androgens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increase lipoprotein binding.

scientific article published on 20 January 2005

Androgens: new effects on proteoglycan biosynthesis and its consequences for atherosclerosis.

scientific article published in July 2005

Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes.

scientific article published on 15 March 2017

Another piece of cell biology in the puzzle of inflammation, glucose and diabetic vascular disease.

scientific article

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle

scientific article

Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen

scientific article published on 16 February 2017

Cardiovascular actions and therapeutic potential of tanshinone IIA ⬇️

scientific article published on June 30, 2011

Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle ⬇️

scientific article published on August 1, 2012

Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans

scientific article

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis ⬇️

scientific article published on April 12, 2011

Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy

scientific article published on 23 March 2018

Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells ⬇️

scientific article published on April 28, 2011

Circulating digoxin-like immunoreactivity in renal hypertensive rabbits: lack of modulation by alterations in dietary sodium intake ⬇️

scientific article published on 01 March 1988

Clinical thiazolidinediones as PPARgamma ligands with the potential for the prevention of cardiovascular disease in diabetes.

scientific article published on May 2006

Danhong Injection in cardiovascular and cerebrovascular diseases: cardiovascular actions, molecular mechanisms, and therapeutic potential

scientific article published on 05 November 2018

Desensitization of the alpha 1 adrenoceptor system in vascular smooth muscle

scientific article published on 01 April 1984

Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries.

scientific article published on 8 June 2005

Diabetes-induced vascular hypertrophy is accompanied by activation of Na(+)-H(+) exchange and prevented by Na(+)-H(+) exchange inhibition

scientific article published on 01 December 2000

Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.

scientific article

Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells

scientific article published on 01 February 1993

Effect of moderate alcohol upon obstructive sleep apnoea

scientific article published in November 2000

Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle

scientific article published on 01 January 1985

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells

scientific article published on 20 November 2016

Endothelial function and dysfunction: Impact of metformin

scientific article published on 27 July 2018

Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis

scientific article published in December 2016

Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis.

scientific article

Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle

scientific article published on 01 March 1992

Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.

scientific article published on 16 March 2008

Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-[beta] type I receptor.

scientific article published on October 2010

Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response.

scientific article

FOXO Signaling Pathways as Therapeutic Targets in Cancer

scientific article published on 6 July 2017

Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2.

scientific article published on 9 February 2018

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.

scientific article

Forkhead box O transcription factors as possible mediators in the development of major depression

scientific article published on 13 August 2015

Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B.

scientific article published on 7 December 2017

Forkhead family transcription factor FoxO and neural differentiation.

scientific article published on 28 March 2012

G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors.

scientific article published on 02 February 2012

G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors.

scientific article published on 3 March 2018

GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways.

scientific article published on 09 April 2013

Gaq proteins: molecular pharmacology and therapeutic potential.

scientific article published on 4 November 2016

Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity.

scientific article published on June 1994

Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation.

scientific article

Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP

scientific article published on 01 April 2008

Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons

scientific article published on 11 August 2020

Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells.

scientific article published in December 2005

Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation.

scientific article

High glucose potentiates mitogenic responses of cultured ovine coronary smooth muscle cells to platelet derived growth factor and transforming growth factor-beta1.

scientific article

IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprusside insult.

scientific article

IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway.

scientific article published on 25 February 2017

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

scientific article

Imidazole derivatives as inhibitors of cytochrome P-450-dependent oxidation and activators of epoxide hydrolase in hepatic microsomes from a marine fish

scientific article published on 01 October 1981

Impact of sleep apnea on sympathetic nervous system activity in heart failure.

scientific article published in April 2003

Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes

scientific article published on 10 November 2018

Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships

scientific article published on 01 August 1982

Inhibitors of hepatic mixed function oxidases--II. Some benzimidazole, benzoxazole and benzothiazole derivatives

scientific article published on 01 December 1976

Inhibitors of hepatic mixed function oxidases--V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives

scientific article published on 01 May 1982

Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats

scientific article published on 01 June 1982

Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation

scientific article published on 12 May 2003

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors.

scientific article published on 6 February 2017

Insulin Resistance and Atherosclerosis

scientific article published on 21 February 2006

Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells.

scientific article published on 2 April 2012

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.

scientific article published on December 2015

Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride-sensitive Na(+)- and HCO3(-)-dependent mechanism

scientific article published on 01 October 1990

Intracellular pH in vascular smooth muscle: regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3- mechanisms

scientific article published on 01 February 1995

Ionic mechanisms regulating sodium entry into vascular smooth muscle ⬇️

scientific article published on February 1, 1991

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.

scientific article

Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2).

scientific article

Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways

scientific article published on 2 December 2015

Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor.

scientific article

Mechanisms involved in the stimulation of aldosterone production by angiotensin II, vasopressin and endothelin

scientific article published on 01 April 1990

Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation

scientific article published on 09 July 2019

Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells.

scientific article published on 18 July 2016

Multiple growth abnormalities in vascular smooth muscle from spontaneously hypertensive rats

scientific article published on 01 May 1991

Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats.

scientific article

New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix.

scientific article published in July 2005

PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.

scientific article published on 7 July 2010

Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease

scientific article

Platelet-derived growth factor differentially regulates the expression and post-translational modification of versican by arterial smooth muscle cells through distinct protein kinase C and extracellular signal-regulated kinase pathways

scientific article

Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation

scientific article published on 23 January 2014

Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications

scientific article published on 03 September 2013

Polyhalogenated biphenyls and phenobarbital: Evaluation as inducers of drug metabolizing enzymes in the sheepshead, Archosargus probatocephalus

scientific article published on 01 August 1981

Potential of small molecule protein tyrosine kinase inhibitors as immuno-modulators and inhibitors of the development of type 1 diabetes

scientific article published on 31 March 2009

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

scientific article published on 5 November 2015

Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms

scientific article published in October 1998

Pyrido-pyrimidine derivative CYC10424 inhibits glycosaminoglycan changes on vascular smooth muscle-derived proteoglycans and reduces lipoprotein binding.

scientific article

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells.

scientific article published on 18 July 2017

ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells

scientific article published on 30 October 2019

Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.

scientific article

Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes

scientific article published on 01 February 1997

Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo

scientific article published on 26 February 2017

Role of cyclic AMP in cardiac beta-adrenoceptor desensitization: studies using prenalterol and inhibitors of phosphodiesterase

scientific article published on 01 September 1984

Siah2-deficient mice show impaired skin wound repair.

scientific article published on 29 April 2013

Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis.

scientific article published on 15 February 2018

Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle

scientific article published on 25 January 2008

Smad linker region phosphorylation in the regulation of extracellular matrix synthesis.

scientific article published on 04 September 2010

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans

scientific article published on 21 September 2012

Spontaneous oscillations in cytoplasmic free calcium concentration in vascular smooth muscle: a potential mechanism associated with myogenic tone

scientific article published on 01 April 1988

Stereoselective reduction of 1-o-isopropyloxygenipin enhances its neuroprotective activity in neuronal cells from apoptosis induced by sodium nitroprusside

scientific article

Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells.

scientific article

TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2.

scientific article published on 7 March 2010

TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle.

scientific article published in October 2011

TWO PATIENTS WITH ABNORMALITIES OF REGIONAL SYMPATHETIC NERVOUS TONE

scientific article published on 01 December 1984

Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet

scientific article published on 26 August 2011

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.

scientific article

Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways

scientific article published on 12 September 2018

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1.

scientific article published on 03 December 2013

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

scientific article published on 01 November 2018

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

scientific article published on 13 November 2018

Temperature-dependent disposition of [14C]benzo(a)pyrene in the spiny lobster, Panulirus argus

scientific article published on 01 February 1985

The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway

scientific article

The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells

scientific article published on 01 July 2008

The effects of endogenous phospholipase A2 activation on beta adrenoceptor function in cardiac cells ⬇️

scientific article published on November 1, 1983

The emerging role of metformin in gestational diabetes mellitus

scientific article published on 27 January 2017

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier.

scientific article

The nerve growth factor signaling and its potential as therapeutic target for glaucoma

scientific article

The paradigm of G protein receptor transactivation: a mechanistic definition and novel example.

scientific article

The possible role of the Akt signaling pathway in schizophrenia.

scientific article published on 04 July 2012

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle.

scientific article

The status of radioimmunotherapy in CD20+ non-Hodgkin's lymphoma.

scientific article published on 29 May 2014

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

scientific article published on 12 July 2021

Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors.

scientific article published on 20 August 2012

Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation.

scientific article

Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells.

scientific article published on 18 January 2013

Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor

scientific article published on 15 January 2015

Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells.

scientific article published on 14 October 2014

Transforming growth factor-beta 1 regulates the expression of ryanodine-sensitive Ca2+ oscillations in cardiac myocytes

scientific article published on 01 October 1994

Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes.

scientific article published on December 2010

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

scientific article published on 11 June 2013

Transforming growth factor-β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells.

scientific article

Treatment of atherosclerotic plaque: perspectives on theranostics

scientific article published on 25 April 2019

Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta.

scientific article published on 27 March 2003

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor‐like domain ⬇️

scientific article published on September 8, 1997

Vascular localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme

scientific article published on 01 June 1996

Zinc and cardiovascular disease.

scientific article

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