List of works - Dan M Granoff

A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines ⬇️

scientific article published on March 2, 2011

A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination ⬇️

scientific article published on February 16, 2011

A broadly cross-reactive monoclonal antibody against an epitope on the n-terminus of meningococcal fHbp.

scientific article published on 28 March 2012

A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine

scientific article published on 19 December 2015

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice

scientific article

A universal vaccine for serogroup B meningococcus

scholarly article

Antibody persistence 3 years after immunization of adolescents with quadrivalent meningococcal conjugate vaccine.

scientific article

Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity

scientific article published on 19 November 2003

Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines

scientific article published on 24 March 2008

Binding of complement factor H (fH) to Neisseria meningitidis is specific for human fH and inhibits complement activation by rat and rabbit sera

scientific article published on December 2008

Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity

scientific article

Breadth and Duration of Meningococcal Serum Bactericidal Activity in Health Care Workers and Microbiologists Immunized with the MenB-FHbp Vaccine

scientific article published on 31 May 2017

Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein ⬇️

scientific article published on November 7, 2011

Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding ⬇️

scientific article published on June 27, 2011

Complement-dependent synergistic bactericidal activity of antibodies against factor H-binding protein, a sparsely distributed meningococcal vaccine antigen

scientific article published in April 2008

Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and neisserial heparin binding antigen.

scientific article

Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H.

scientific article

Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses? ⬇️

scientific article published on 05 June 2013

ERRATUM: A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp.

scientific article

Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults

scientific article

Effect of Factor H-Binding Protein Sequence Variation on Factor H Binding and Survival of Neisseria meningitidis in Human Blood ⬇️

scientific article published on November 1, 2010

Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine

scientific article

Effectiveness Analyses May Underestimate Protection of Infants after Group C Meningococcal Immunization

scientific article published on 13 June 2006

Enhanced Bacteremia in Human Factor H Transgenic Rats Infected by Neisseria meningitidis ⬇️

scientific article published on November 21, 2011

Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding

scientific article published on 08 September 2016

Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity

scientific article published on April 2009

Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis

scientific article published on 15 October 2013

Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor h-binding protein

scientific article

Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic

scientific article

GNA33 of Neisseria meningitidis is a lipoprotein required for cell separation, membrane architecture, and virulence.

scientific article

Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines

scientific article

Highly ConservedNeisseria meningitidisInner‐Core Lipopolysaccharide Epitope Confers Protection against Experimental Meningococcal Bacteremia ⬇️

scientific article published on 02 April 2003

Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding

scientific article

Immunity to Neisseria meningitidis group B in adults despite lack of serum bactericidal antibody

scientific article

Immunogenicity of an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine in 2-year old children

scientific article published on 01 July 2005

Impaired Immunogenicity of Meningococcal Neisserial Surface Protein A in Human Complement Factor H Transgenic Mice

scientific article published on 23 November 2015

Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor h binding

scientific article

Improved immunogenicity of a H44/76 group B outer membrane vesicle vaccine with over-expressed genome-derived Neisserial antigen 1870

scientific article published on 21 April 2006

Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model

scientific article

Meningococcal Factor H Binding Proteins in Epidemic Strains from Africa: Implications for Vaccine Development ⬇️

scientific article published on September 6, 2011

Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice

scientific article published on 11 September 2013

Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies

scientific article

Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity

scientific article (publication date: 2012)

Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa

scientific article

NadA, a novel vaccine candidate of Neisseria meningitidis

scientific article

Naturally acquired passive protective activity against Neisseria meningitidis Group C in the absence of serum bactericidal activity

scientific article published on October 2004

Neisseria meningitidis urethritis outbreak isolates express a novel factor H binding protein allele that is a potential target of MenB directed meningococcal vaccines

scientific article published on 21 September 2020

Persistence of group C anticapsular antibodies two to three years after immunization with an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine

scientific article

Priming for immunologic memory in adults by meningococcal group C conjugate vaccination

scientific article

Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a Neisseria meningitidis candidate vaccine

scientific article published on May 2004

Protective antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed genome-derived neisserial antigen 1870

scientific article published on 15 July 2005

Rapid genetic grouping of factor h-binding protein (genome-derived neisserial antigen 1870), a promising group B meningococcal vaccine candidate

scientific article

Reconsideration of the use of meningococcal polysaccharide vaccine

scientific article published on August 2007

Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection

scientific article

Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strains

scientific article

Serum Bactericidal Antibody Responses of Adults Immunized with the MenB-4C Vaccine against Genetically Diverse Serogroup B Meningococci.

scientific article

Serum Bactericidal Antibody Responses of Students Immunized With a Meningococcal Serogroup B Vaccine in Response to an Outbreak on a University Campus

scientific article published on 3 June 2017

The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein ⬇️

scientific article published on May 10, 2012

The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance

scientific article

The role of anti-NHba antibody in bactericidal activity elicited by the meningococcal serogroup B vaccine, MenB-4C.

scientific article published on 23 June 2017

Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870

scientific article

fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations.

scientific article published on 17 June 2013

List of works by Dan M Granoff

A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines ⬇️

A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination ⬇️

A broadly cross-reactive monoclonal antibody against an epitope on the n-terminus of meningococcal fHbp.

A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice

A universal vaccine for serogroup B meningococcus

Antibody persistence 3 years after immunization of adolescents with quadrivalent meningococcal conjugate vaccine.

Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity

Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines

Binding of complement factor H (fH) to Neisseria meningitidis is specific for human fH and inhibits complement activation by rat and rabbit sera

Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity

Breadth and Duration of Meningococcal Serum Bactericidal Activity in Health Care Workers and Microbiologists Immunized with the MenB-FHbp Vaccine

Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein ⬇️

Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding ⬇️

Complement-dependent synergistic bactericidal activity of antibodies against factor H-binding protein, a sparsely distributed meningococcal vaccine antigen

Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and neisserial heparin binding antigen.

Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H.

Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses? ⬇️

ERRATUM: A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp.

Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults

Effect of Factor H-Binding Protein Sequence Variation on Factor H Binding and Survival of Neisseria meningitidis in Human Blood ⬇️

Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine

Effectiveness Analyses May Underestimate Protection of Infants after Group C Meningococcal Immunization

Enhanced Bacteremia in Human Factor H Transgenic Rats Infected by Neisseria meningitidis ⬇️

Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding

Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity

Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis

Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate factor h-binding protein

Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic

GNA33 of Neisseria meningitidis is a lipoprotein required for cell separation, membrane architecture, and virulence.

Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines

Highly ConservedNeisseria meningitidisInner‐Core Lipopolysaccharide Epitope Confers Protection against Experimental Meningococcal Bacteremia ⬇️

Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding

Immunity to Neisseria meningitidis group B in adults despite lack of serum bactericidal antibody

Immunogenicity of an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine in 2-year old children

Impaired Immunogenicity of Meningococcal Neisserial Surface Protein A in Human Complement Factor H Transgenic Mice

Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor h binding

Improved immunogenicity of a H44/76 group B outer membrane vesicle vaccine with over-expressed genome-derived Neisserial antigen 1870

Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model

Meningococcal Factor H Binding Proteins in Epidemic Strains from Africa: Implications for Vaccine Development ⬇️

Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice

Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies

Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity

Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa

NadA, a novel vaccine candidate of Neisseria meningitidis

Naturally acquired passive protective activity against Neisseria meningitidis Group C in the absence of serum bactericidal activity

Neisseria meningitidis urethritis outbreak isolates express a novel factor H binding protein allele that is a potential target of MenB directed meningococcal vaccines

Persistence of group C anticapsular antibodies two to three years after immunization with an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine

Priming for immunologic memory in adults by meningococcal group C conjugate vaccination

Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a Neisseria meningitidis candidate vaccine

Protective antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed genome-derived neisserial antigen 1870

Rapid genetic grouping of factor h-binding protein (genome-derived neisserial antigen 1870), a promising group B meningococcal vaccine candidate

Reconsideration of the use of meningococcal polysaccharide vaccine

Role of FNR and FNR-regulated, sugar fermentation genes in Neisseria meningitidis infection

Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strains

Serum Bactericidal Antibody Responses of Adults Immunized with the MenB-4C Vaccine against Genetically Diverse Serogroup B Meningococci.

Serum Bactericidal Antibody Responses of Students Immunized With a Meningococcal Serogroup B Vaccine in Response to an Outbreak on a University Campus

The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein ⬇️

The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance

The role of anti-NHba antibody in bactericidal activity elicited by the meningococcal serogroup B vaccine, MenB-4C.

Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870

fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations.