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List of works by Radhakrishnan Mahalakshmi

Approaches for Preparation and Biophysical Characterization of Transmembrane β-Barrels

Aromatic interactions in β-hairpin scaffold stability: A historical perspective

scientific article published on 03 November 2018

Asymmetric Contribution of Aromatic Interactions Stems from Spatial Positioning of the Interacting Aryl Pairs in β-Hairpins

scientific article published in 2014

Capping β-hairpin with N-terminald-amino acid stabilizes peptide scaffold

scientific article published in 2016

Characterization of folded conformations in a tetrapeptide containing two tryptophan residues by vibrational circular dichroism.

scientific article published in January 2009

Circular dichroism of designed peptide helices and beta-hairpins: analysis of Trp- and Tyr-rich peptides.

scientific article published in December 2005

Comparative analysis of cross strand aromatic–Phe interactions in designed peptide β-hairpins

article

Control of human VDAC-2 scaffold dynamics by interfacial tryptophans is position specific

scientific article

Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2

scientific article

Differential contribution of tryptophans to the folding and stability of the attachment invasion locus transmembrane β-barrel from Yersinia pestis

scientific article

Direct Structural Annotation of Membrane Protein Aggregation Loci using Peptide-Based Reverse Mapping.

scientific article published on 21 May 2018

Distinct Structural Elements Govern the Folding, Stability, and Catalysis in the Outer Membrane Enzyme PagP.

scientific article published on 15 August 2016

Energetics of side-chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein

scientific article published on 7 June 2017

Engineering a Hyperstable <i>Yersinia pestis</i> Outer Membrane Protein Ail Using Thermodynamic Design

scientific article published on 21 January 2022

Engineering a Transmembrane Nanopore Ion Channel from a Membrane Breaker Peptide

scientific article

Evolutionary selection of a 19-stranded mitochondrial β-barrel scaffold bears structural and functional significance

scientific article published on 19 August 2020

Expression, refolding, and initial structural characterization of the Y. pestis Ail outer membrane protein in lipids

scientific article published on 29 September 2010

Folding Determinants of Transmembrane β-Barrels Using Engineered OMP Chimeras

scientific article published in 2018

Folding and Stability of Transmembrane b-Barrels of Bacterial and Human Origin: Probing Underlying Similarities and Principal Differences Using In vitro Systems

Functional characterization of the pentapeptide QYNAD on rNav1.2 channels and its NMR structure

scientific article published on 23 December 2003

Helix-strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3

scientific article published on 23 January 2019

Hydrophobic Characteristic Is Energetically Preferred for Cysteine in a Model Membrane Protein

scientific article published on 05 June 2019

Implications of aromatic-aromatic interactions: From protein structures to peptide models

scientific article

Influence of protein-micelle ratios and cysteine residues on the kinetic stability and unfolding rates of human mitochondrial VDAC-2

scientific article

Interplay of protein primary sequence, lipid membrane, and chaperone in β-barrel assembly

scientific article published on 07 January 2021

Juxtamembrane tryptophans have distinct roles in defining the OmpX barrel-micelle boundary and facilitating protein-micelle association

scientific article

Metamorphic Proteins: Emergence of Dual Protein Folds from One Primary Sequence.

scientific article

Methionine mutations of outer membrane protein X influence structural stability and beta-barrel unfolding

scientific article (publication date: 2013)

Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities

scientific article published on 7 November 2016

Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel

scientific article

Modulation of Human Mitochondrial Voltage-dependent Anion Channel 2 (hVDAC-2) Structural Stability by Cysteine-assisted Barrel-lipid Interactions ⬇️

scientific article published on July 19, 2013

Molecular Mechanism of Holin Transmembrane Domain I in Pore Formation and Bacterial Cell Death

scientific article published on 23 December 2015

Molecular Switch between Structural Compaction and Thermodynamic Stability by the Xxx-Pro Interface in Transmembrane β-Barrels

scientific article published on 12 December 2019

N-helix and Cysteines Inter-regulate Human Mitochondrial VDAC-2 Function and Biochemistry

scientific article

NMR Analysis of Tuning Cross-Strand Phe/Tyr/Trp-Trp Interactions in Designed β-Hairpin Peptides: Terminal Switch from L to D Amino Acid as a Strategy for β-Hairpin Capping

scientific article published on 16 April 2015

NMR analysis of aromatic interactions in designed peptide beta-hairpins

scientific article published in February 2006

NMR structural studies of the bacterial outer membrane protein OmpX in oriented lipid bilayer membranes

scientific article published on 24 August 2007

Nature of aryl–tyrosine interactions contribute to β-hairpin scaffold stability: NMR evidence for alternate ring geometry

article

Non-protein amino acids in the design of secondary structure scaffolds

scientific article published on January 2006

Orientation of the Escherichia coli outer membrane protein OmpX in phospholipid bilayer membranes determined by solid-State NMR.

scientific article

Position-Specific contribution of interface tryptophans on membrane protein energetics

scientific article published on 8 November 2017

Pro-Gly mediated conformational switch of mycobacteriophage D29 holin transmembrane domain I is lipid concentration driven.

scientific article

Residue-Dependent Thermodynamic Cost and Barrel Plasticity Balances Activity in the PhoPQ-Activated Enzyme PagP of Salmonella typhimurium

scientific article

Role of cysteines in mammalian VDAC isoforms' function

scientific article published on 3 March 2016

Salvaging the thermodynamic destabilization of interface histidine in transmembrane β-barrels

scientific article published in 2018

Single-residue physicochemical characteristics kinetically partition membrane protein self-assembly and aggregation

scientific article published on 16 December 2019

Solvation driven conformational transitions in the second transmembrane domain of mycobacteriophage holin.

scientific article published on 10 June 2016

Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins

scientific article published in October 2013

Stereopositional Outcome in the Packing of Dissimilar Aromatics in Designed β-Hairpins

scientific article published on 11 February 2016

Structural plasticity of T4 transcription co-activator gp33 revealed by a protease-resistant unfolded state

scientific article published on 11 August 2017

Structure Stabilizing Role of Aromatic Interactions is Decided by Spatial Arrangement of Aromatic Pairs: A Case Study with Designed Peptide β-Hairpins

Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: case study from bacteria and humans

scholarly article in RSC Advances, vol. 5 no. 2, 2015

Transmembrane β-barrels: Evolution, folding and energetics

scientific article

Trp-Trp Cross-Linking: A Structure-Reactivity Relationship in the Formation and Design of Hyperstable Peptide β-Hairpin and α-Helix Scaffolds

scientific article published on 4 May 2015

Tryptophan rich peptides: Influence of indole rings on backbone conformation

scientific article published in 2007

Tryptophan-containing peptide helices: interactions involving the indole side chain.

scientific article

Unexpected Modifications of Cysteines in VDAC3: Indication that VDAC3 may Signal the Mitochondrial Intermembrane Redox State

Unusual post-translational protein modifications: the benefits of sophistication

scholarly article in RSC Advances, vol. 4 no. 64, 2014

VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel?

scientific article published on 28 December 2015

VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications.

scientific article published on 8 January 2016

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