List of works - Peter J. Crouch

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

scientific article published on June 2010

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

scientific article published on 16 September 2011

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

scientific article

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

scientific article published on 20 May 2013

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

scientific article published on 15 December 2011

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1

scientific article published on 01 January 2019

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

scientific article

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

scientific article published on 8 October 2010

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

scientific article published on 30 August 2016

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

scientific article

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis

scientific article

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD

scientific article

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

scientific article

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper.

scientific article published on 21 December 2010

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

scientific article published on 04 November 2020

Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide

scientific article published in October 2006

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

scientific article published in January 2005

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

scientific article published on 13 February 2017

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

scientific article

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

scientific article

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

scientific article published on 27 October 2011

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

scientific article published on November 2007

Editorial: Metals and neurodegeneration: restoring the balance.

scientific article published on 2 July 2015

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

scientific article published on 30 June 2016

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

scientific article published on 27 January 2012

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

scientific article published on 20 June 2013

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

scientific article published on 27 July 2016

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease

scientific article published in November 2011

Glycogen synthase kinase-3.

scientific article

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).

scientific article

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

scientific article published on 11 February 2014

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

scientific article

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

scientific article

Intracellular distribution of fluorescent copper and zinc bis(thiosemicarbazonato) complexes measured with fluorescence lifetime spectroscopy

scientific article published on 23 September 2015

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

scientific article

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

scientific article

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

scientific article

Linker histone H1 binds to disease associated amyloid-like fibrils

scientific article

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

scientific article published on 4 February 2013

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

scientific article published on 14 March 2014

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

scientific article

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

scientific article published on August 2007

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

scientific article published on February 2009

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

scientific article (publication date: 2011)

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

scientific article

Mitochondria in aging and Alzheimer's disease.

scientific article published on September 2007

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells

scientific article published on 6 April 2013

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

scientific article published on 14 May 2016

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

scientific article

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

scientific article

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

scientific article

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

scientific article published on 23 August 2015

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

scientific article published in 2022

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

scientific article

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

scientific article published on 25 January 2010

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

scientific article published on 19 September 2011

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

scientific article published on November 2009

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

scientific article

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

scientific article

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

scientific article published on 6 July 2007

The role of metals in modulating metalloprotease activity in the AD brain.

scientific article published on 13 February 2008

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

scientific article published on 19 August 2013

Therapeutic redistribution of metal ions to treat Alzheimer's disease

scientific article published on 29 June 2012

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

scientific article

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

scientific article published on October 2006

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes

scientific article published on 16 September 2015

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

scientific article

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

scientific article

List of works by Peter J. Crouch

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper.

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

Editorial: Metals and neurodegeneration: restoring the balance.

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease

Glycogen synthase kinase-3.

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

Intracellular distribution of fluorescent copper and zinc bis(thiosemicarbazonato) complexes measured with fluorescence lifetime spectroscopy

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

Linker histone H1 binds to disease associated amyloid-like fibrils

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

Mitochondria in aging and Alzheimer's disease.

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

The role of metals in modulating metalloprotease activity in the AD brain.

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

Therapeutic redistribution of metal ions to treat Alzheimer's disease

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.