List of works - Huaibin Cai

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

scientific article

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

scientific article

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.

scientific article published on 23 January 2018

ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

scientific article published on 05 March 2019

ALS2/alsin knockout mice and motor neuron diseases

scientific article published on 20 August 2008

Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress

scientific article

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease

scientific article

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

scientific article

Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.

scientific article

Alsin and the molecular pathways of amyotrophic lateral sclerosis

scientific article published on 10 July 2007

Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury ⬇️

scientific article published on October 5, 2012

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

scientific article

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons

Animal models of Parkinson's disease

scientific article published on 18 December 2011

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease

scientific article published on 2 March 2015

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.

scientific article

Autophagy in neurodegenerative diseases: pathogenesis and therapy.

scientific article

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

scientific article

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

scientific article

Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?

scientific article published on January 2014

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice ⬇️

scientific article published on November 14, 2012

Coding mutations in contribute to Parkinson's disease

article published in the Proceedings of the National Academy of Sciences of the United States of America

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1

scientific article

Deletion at ITPR1 underlies ataxia in mice and humans (SCA15)

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

scientific article published in June 2007

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

scientific article

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

scientific article

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

scientific article

Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis

scientific article published on 26 January 2018

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

scientific article published in March 2018

In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.

scientific article

LRRK2 function on actin and microtubule dynamics in Parkinson disease

scientific article

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways

scientific article

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

scientific article

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

scientific article published on 11 June 2015

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

scientific article

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

scientific article

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.

scientific article published on 28 August 2015

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

scientific journal article

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

scientific article

Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.

scientific article published on 6 December 2006

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

scientific article published on 2 November 2012

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina

scientific article published on 12 April 2007

Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity

scientific article published on 17 January 2013

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

scientific article

Nurr1-Based Therapies for Parkinson's Disease.

scientific article published on 25 March 2016

Opioid system in L-DOPA-induced dyskinesia

scientific article published on 17 January 2017

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons

scientific article

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

scientific article published on January 2014

Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

scientific article published on 19 February 2020

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

scientific article

Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif

scientific article published on 7 September 2017

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

scientific article

Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression.

scientific article published on 21 April 2016

Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.

scientific article published on 3 February 2017

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

scientific article

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

scientific article

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

scientific article

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.

scientific article published on 28 February 2017

Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression

scientific article published on 19 April 2017

The G59S mutation in p150(glued) causes dysfunction of dynactin in mice

scientific article published on December 2007

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

scientific article

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

scientific article

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.

scientific article published in July 2015

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

scientific article published on 19 March 2019

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.

scientific article published on April 2016

α-synuclein, LRRK2 and their interplay in Parkinson's disease.

scientific article

List of works by Huaibin Cai

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.

ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

ALS2/alsin knockout mice and motor neuron diseases

Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.

Alsin and the molecular pathways of amyotrophic lateral sclerosis

Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury ⬇️

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons

Animal models of Parkinson's disease

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.

Autophagy in neurodegenerative diseases: pathogenesis and therapy.

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice ⬇️

Coding mutations in contribute to Parkinson's disease

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1

Deletion at ITPR1 underlies ataxia in mice and humans (SCA15)

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.

LRRK2 function on actin and microtubule dynamics in Parkinson disease

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina

Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

Nurr1-Based Therapies for Parkinson's Disease.

Opioid system in L-DOPA-induced dyskinesia

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression.

Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.

Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression

The G59S mutation in p150(glued) causes dysfunction of dynactin in mice

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.

α-synuclein, LRRK2 and their interplay in Parkinson's disease.