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List of works by Zheng Jian Li

A CFD Model for Predicting Protein Aggregation in Low-pH Virial Inactivation for mAb Production

scientific article published on 16 July 2020

A novel approach enables imaged capillary isoelectric focusing analysis of PEGylated proteins

scientific article published on 22 January 2020

Assessment of CE-based baseline disturbances using simulation and targeted experimental evaluation-impact on the purity determination of therapeutic proteins

scientific article published on 18 March 2019

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

scientific article published on 19 May 2020

Contributions of depth filter components to protein adsorption in bioprocessing

scientific article published on 01 May 2018

DNA RETENTION ON DEPTH FILTERS

scientific article published on 24 October 2018

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

scientific article published on 01 January 2020

Early identification of unusually clustered mutations and root causes in therapeutic antibody development

scientific article published on 06 June 2018

Evaluation of chromatofocusing as a capture method for monoclonal antibody products

scientific article published on 06 July 2018

High-efficiency affinity precipitation of multiple industrial mAbs and Fc-fusion proteins from cell culture harvests using Z-ELP-E2 nanocages.

scientific article published on 21 April 2018

Hypoxia and transforming growth factor-beta1 pathway activation promote Chinese Hamster Ovary cell aggregation.

scientific article published on 18 December 2017

Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media.

scientific article published in February 2018

Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines

scientific article published on 09 January 2020

Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles

scientific article published on 31 March 2018

Kinetic modeling of Chinese hamster ovary cell culture: factors and principles

scientific article published on 12 January 2020

Mechanisms of precipitate formation during the purification of an Fc-fusion protein

Mechanistic modeling based process development for monoclonal antibody monomer-aggregate separations in multimodal cation exchange chromatography

scientific article published on 06 June 2019

Minimization of artifact protein aggregation using tetradecyl sulfate and hexadecyl sulfate in capillary gel electrophoresis under reducing conditions

scientific article published on 16 April 2020

Model assisted comparison of Protein A resins and multi-column chromatography for capture processes

scientific article published on 27 August 2018

Model assisted process characterization and validation for a continuous two-column protein A capture process

article

Modulating cell culture oxidative stress reduces protein glycation and acidic charge variant formation

scientific article published on 03 January 2019

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

scientific article published on 01 January 2020

One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages

scientific article published on 7 October 2017

Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

scientific article published on 01 January 2020

Process intensification in fed-batch production bioreactors using non-perfusion seed cultures

scientific article published on 19 August 2019

Protection of therapeutic antibodies from visible light induced degradation: use safe light in manufacturing and storage

scientific article published on 7 February 2018

Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification

scientific article published on 02 September 2019

Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application For Therapeutic Protein Characterization

scientific article published on 22 January 2018

Real Time Monitoring of Quality Attributes by In-line Fourier Transform Infrared Spectroscopic Sensors at Ultrafiltration and Diafiltration of Bioprocess

scientific article published on 10 August 2020

Strategies for High Concentration Drug Substance Manufacturing to Facilitate Subcutaneous Administration: A Review

scientific article published on 20 July 2020

Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling

scientific article published on 02 October 2018

Technology outlook for real-time quality attribute and process parameter monitoring in biopharmaceutical development-A review

scientific article published on 01 July 2020

Ultrafiltration behavior of monoclonal antibodies and Fc-fusion proteins: Effects of physical properties.

scientific article published on 2 May 2017

Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization

scientific article published on 11 December 2019

Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

publication published on 01 January 2021

Virus clearance validation across continuous capture chromatography

scientific article published on 27 May 2019

Vitamin B12 association with mAbs: Mechanism and potential mitigation strategies.

scientific article published on 2 December 2017

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