List of works - Theodoros Eleftheriadis

A cohort of fat enough but malnourished hemodialysis patients

scientific article published on 21 October 2019

A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity

scientific article published on 16 June 2017

A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin

scientific article published on 02 May 2020

Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition

scientific article published on 05 December 2019

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

scientific article published on 27 July 2016

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction.

scientific article

Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis

scientific article published on 06 October 2016

Animal models in peritoneal dialysis

scientific article

Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?

article

Arginase type I as a marker of coronary heart disease in hemodialysis patients

scientific article published on 15 September 2010

Association between the interleukin-1β Gene (IL1B) C-511T polymorphism and the risk of diabetic nephropathy in type 2 diabetes: a candidate-gene association study.

scientific article

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review ⬇️

article

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial.

scientific article published on 5 May 2017

CD8+ T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells.

scientific article published on 14 June 2013

Cell Death Patterns Due to Warm Ischemia or Reperfusion in Renal Tubular Epithelial Cells Originating from Human, Mouse, or the Native Hibernator Hamster

scientific article published on 15 November 2018

Clinic and Home Blood Pressure Monitoring for the Detection of Ambulatory Hypertension Among Patients on Peritoneal Dialysis

scientific article published on 12 August 2019

Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.

scientific article published on 11 September 2017

Correction to: Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways

scientific article

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation

scientific article published on 23 May 2019

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

scientific article

Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation

scientific article published on 21 March 2013

Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

scientific article published on 15 August 2019

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4⁺ T-cells.

scientific article published in April 2016

Endothelin-1 acutely reduces the permeability of visceral sheep peritoneum in vitro through both endothelin-A and endothelin-B receptors

scientific article published on 01 February 2013

Energy handling in renal tubular epithelial cells of the hamster, a native hibernator, under warm anoxia or reoxygenation

scientific article published on 12 October 2018

Expression of Circulating MicroRNAs Linked to Bone Metabolism in Chronic Kidney Disease-Mineral and Bone Disorder

scientific article published on 12 December 2020

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

scientific article

Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation

scientific article published on 31 March 2019

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation.

scientific article

Impact of proton pump inhibitor use on magnesium homoeostasis: a cross-sectional study in a tertiary emergency department

scientific article published on 04 June 2014

Improvements in the Management of Diabetic Nephropathy

scientific article

In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity

scientific article published on 04 October 2020

In human alloreactive CD4⁺ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets.

scientific article

In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity.

scientific article

Increased plasma angiogenin level is associated and may contribute to decreased T-cell zeta-chain expression in hemodialysis patients

scientific article published on 30 October 2012

Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin.

scientific article published on 21 August 2013

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells.

scientific article

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

scientific article published on 26 July 2014

Indoleamine 2,3-dioxygenase suppresses humoral alloimmunity via pathways that different to those associated with its effects on T cells.

scientific article published on 16 May 2019

Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells.

scientific article published on 23 September 2016

Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.

scientific article published on 20 November 2015

Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.

scientific article

Inhibition of indoleamine 2,3-dioxygenase not only blocks autoreactive B cell activation, but it also reduces production of antibodies in general: comment on the article by Pigott and Mandik-Nayak

scientific article published on 01 July 2013

Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

scientific article

Is oxidative stress an issue in peritoneal dialysis?

scientific article published on 01 May 2019

Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation

scientific article published on 29 August 2015

Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia.

scientific article

Late-onset Pompe's disease in a hemodialysis patient: A first case report.

scientific article

Like total ghrelin, acylated ghrelin is also lower in HD patients with cardiovascular disease

scientific article published on 01 October 2011

Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.

scientific article

Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm.

scientific article published on 16 June 2014

Mineralocorticoid Antagonists in ESRD: An Overview of Clinical Trial Evidence.

scientific article

Mistimed H2S upregulation, Nrf2 activation and antioxidant proteins levels in renal tubular epithelial cells subjected to anoxia and reoxygenation

scientific article published on 02 June 2020

Osteoporosis after renal transplantation.

scientific article

Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future Perspectives.

scientific article

Oxidative Stress and the Kidney in the Space Environment

scientific article

Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature.

scientific article published on 27 December 2017

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

article

Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile

scientific article published on 07 June 2012

Peritoneal dialysis-related infections recommendations: 2016 update. What is new?

scientific article published on June 2017

Phosphorus nutritional knowledge among dialysis health care providers and patients: A multicenter observational study

scientific article published on 04 April 2019

Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients

scientific article published on 17 August 2012

Plasma vascular endothelial growth factor and angiogenin are positively related to erythropoietin dose in hemodialysis patients.

scientific article published in January 2013

Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy.

scientific article published on 17 April 2017

Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions.

scientific article published on 26 February 2016

Quiz: Nine Years of Persistent, Disabling Foot Pain in a Kidney Transplant Recipient

scientific article published on 01 August 2017

Renal manifestations and complications of inflammatory bowel disease ⬇️

scientific article published on September 14, 2010

Restless legs syndrome and mortality in hemodialysis patients.

scientific article published in December 2015

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients.

scientific article published on 19 June 2015

Restless legs syndrome in hemodialysis patients: an epidemiologic survey in Greece.

scientific article

SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?

scientific article published on 01 January 2019

Screening for renal cell carcinoma in dialysis patients

scientific article published on 01 December 2018

Serum copper and ferroportin in monocytes of hemodialysis patients are both decreased but unassociated

scientific article published on 8 May 2014

Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients

scientific article published on 08 January 2013

Sternal instability in a hemodialysis patient with secondary hyperparathyroidism

scientific article published on 04 April 2014

T helper (Th)-cytokines in the urine of patients with primary glomerulonephritis treated with immunosuppressive drugs: Can they predict outcome?

scientific article

Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is Related With Telomerase Activity and Treatment Duration

scientific article published on 20 April 2015

The H2S-Nrf2-Antioxidant Proteins Axis Protects Renal Tubular Epithelial Cells of the Native Hibernator Syrian Hamster from Reoxygenation-Induced Cell Death

scientific article published on 30 September 2019

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis

article

Toll-like receptors and kidney diseases.

scientific article published on July 2009

Toll-like receptors and their role in renal pathologies.

scientific article published on December 2012

Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways.

scientific article published on 4 February 2017

Unfavorable Effects of Peritoneal Dialysis Solutions on the Peritoneal Membrane: The Role of Oxidative Stress

scientific article published on 14 May 2020

Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation

scientific article published on 4 August 2017

Uric acid and cellular and humoral alloimmunity

scientific article published on 08 August 2018

Uric acid increases cellular and humoral alloimmunity in primary human peripheral blood mononuclear cells.

scientific article

What May Constrain the Success of Indoleamine 2,3-Dioxygenase 1 Inhibitors in Cancer Immunotherapy?

scientific article published on 13 August 2018

Which is the best way for estimating transferrin saturation?

scientific article published on 01 January 2010

Xanthine oxidase inhibitors may prevent or slow chronic kidney disease even in the absence of hyperuricemia

scientific article published on 01 October 2018

List of works by Theodoros Eleftheriadis

A cohort of fat enough but malnourished hemodialysis patients

A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity

A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin

Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction.

Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis

Animal models in peritoneal dialysis

Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?

Arginase type I as a marker of coronary heart disease in hemodialysis patients

Association between the interleukin-1β Gene (IL1B) C-511T polymorphism and the risk of diabetic nephropathy in type 2 diabetes: a candidate-gene association study.

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review ⬇️

Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial.

CD8+ T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells.

Cell Death Patterns Due to Warm Ischemia or Reperfusion in Renal Tubular Epithelial Cells Originating from Human, Mouse, or the Native Hibernator Hamster

Clinic and Home Blood Pressure Monitoring for the Detection of Ambulatory Hypertension Among Patients on Peritoneal Dialysis

Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.

Correction to: Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation

Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4⁺ T-cells.

Endothelin-1 acutely reduces the permeability of visceral sheep peritoneum in vitro through both endothelin-A and endothelin-B receptors

Energy handling in renal tubular epithelial cells of the hamster, a native hibernator, under warm anoxia or reoxygenation

Expression of Circulating MicroRNAs Linked to Bone Metabolism in Chronic Kidney Disease-Mineral and Bone Disorder

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation.

Impact of proton pump inhibitor use on magnesium homoeostasis: a cross-sectional study in a tertiary emergency department

Improvements in the Management of Diabetic Nephropathy

In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity

In human alloreactive CD4⁺ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets.

In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity.

Increased plasma angiogenin level is associated and may contribute to decreased T-cell zeta-chain expression in hemodialysis patients

Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin.

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells.

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

Indoleamine 2,3-dioxygenase suppresses humoral alloimmunity via pathways that different to those associated with its effects on T cells.

Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells.

Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.

Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.

Inhibition of indoleamine 2,3-dioxygenase not only blocks autoreactive B cell activation, but it also reduces production of antibodies in general: comment on the article by Pigott and Mandik-Nayak

Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

Is oxidative stress an issue in peritoneal dialysis?

Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation

Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia.

Late-onset Pompe's disease in a hemodialysis patient: A first case report.

Like total ghrelin, acylated ghrelin is also lower in HD patients with cardiovascular disease

Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.

Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm.

Mineralocorticoid Antagonists in ESRD: An Overview of Clinical Trial Evidence.

Mistimed H2S upregulation, Nrf2 activation and antioxidant proteins levels in renal tubular epithelial cells subjected to anoxia and reoxygenation

Osteoporosis after renal transplantation.

Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future Perspectives.

Oxidative Stress and the Kidney in the Space Environment

Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature.

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile

Peritoneal dialysis-related infections recommendations: 2016 update. What is new?

Phosphorus nutritional knowledge among dialysis health care providers and patients: A multicenter observational study

Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients

Plasma vascular endothelial growth factor and angiogenin are positively related to erythropoietin dose in hemodialysis patients.

Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy.

Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions.

Quiz: Nine Years of Persistent, Disabling Foot Pain in a Kidney Transplant Recipient

Renal manifestations and complications of inflammatory bowel disease ⬇️

Restless legs syndrome and mortality in hemodialysis patients.

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients.

Restless legs syndrome in hemodialysis patients: an epidemiologic survey in Greece.

SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?

Screening for renal cell carcinoma in dialysis patients

Serum copper and ferroportin in monocytes of hemodialysis patients are both decreased but unassociated

Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients

Sternal instability in a hemodialysis patient with secondary hyperparathyroidism

T helper (Th)-cytokines in the urine of patients with primary glomerulonephritis treated with immunosuppressive drugs: Can they predict outcome?

Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is Related With Telomerase Activity and Treatment Duration

The H2S-Nrf2-Antioxidant Proteins Axis Protects Renal Tubular Epithelial Cells of the Native Hibernator Syrian Hamster from Reoxygenation-Induced Cell Death

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis