List of works - Lynne Regan

A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics.

scientific article

A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines

scientific article

A designed repeat protein as an affinity capture reagent

scientific article

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

scientific article

A modular approach to the design of protein-based smart gels

scientific article

A new bright green-emitting fluorescent protein--engineered monomeric and dimeric forms

scientific article published on 18 March 2010

A new method for the covalent attachment of DNA to a surface for single-molecule studies

scientific article

A novel class of small molecule inhibitors of Hsp90.

scientific article published on 12 September 2008

A recurring theme in protein engineering: the design, stability and folding of repeat proteins.

scientific article

A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics

scientific article published on 10 June 2009

A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals

scientific article published on 18 April 2016

All repeats are not equal: a module-based approach to guide repeat protein design

scientific article published on 19 February 2013

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction

scientific article

Analysis of side chain mobility among protein G B1 domain mutants with widely varying stabilities

scientific article published on 10 November 2004

Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP.

scientific article

Calorimetric study of a series of designed repeat proteins: modular structure and modular folding

scientific article

Combinatorial approaches to protein stability and structure.

scientific article

Consensus design as a tool for engineering repeat proteins.

scientific article published on January 2006

Creating novel proteins by combining design and selection

scientific article

Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand

scientific article

Design of Stable α-Helical Arrays from an Idealized TPR Motif ⬇️

scientific article (publication date: May 2003)

Designed phosphoprotein recognition in Escherichia coli

scientific article published on 6 October 2014

Designed proteins to modulate cellular networks

scientific article

Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.

scientific article

Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90: COMPUTATIONAL ANALYSIS AND PROTEIN ENGINEERING

scientific article

Equilibrium transitions between side-chain conformations in leucine and isoleucine.

scientific article

Fragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein

scientific article

HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP.

scientific article

Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP

scientific article

Intensification: A Resource for Amplifying Population-Genetic Signals with Protein Repeats

scientific article

Intrinsic α-helical and β-sheet conformational preferences: a computational case study of alanine.

scientific article

Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome

scientific article published on 31 August 2012

LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions

scientific article published on 20 August 2020

Library approaches to biophysical problems.

scientific article

Ligand binding by TPR domains

scientific article

Ligand binding by repeat proteins: natural and designed

scientific article published on 23 July 2008

Local and long-range stability in tandemly arrayed tetratricopeptide repeats

scientific article

Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchange

scientific article

Molten globules move into action

scholarly article

Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro

scientific article published on March 2003

Nanostructured functional films from engineered repeat proteins.

scientific article

New insights into the interdependence between amino acid stereochemistry and protein structure

scientific article

New materials from proteins and peptides

scientific article published on 23 July 2012

NextGen protein design

scientific article

Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state.

scientific article published on 11 July 2008

Predicting the side-chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models.

scientific article

Promoting convergence: The integrated graduate program in physical and engineering biology at Yale University, a new model for graduate education

scientific article published on 13 June 2016

Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins.

scientific article

Protein design: Past, present, and future

scientific article

Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area

scientific article

Random close packing in protein cores. ⬇️

scientific article

Reads meet rotamers: structural biology in the age of deep sequencing

scientific article

Reassembled GFP: detecting protein-protein interactions and protein expression patterns

scientific article

Redesign of a protein - peptide interaction: Characterization and applications

scientific article

Revisiting the Ramachandran plot from a new angle

scientific article published on 31 May 2011

Routes to DNA accessibility: alternative pathways for nucleosome unwinding.

scientific article

Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay

scientific article

Sequence variation in ligand binding sites in proteins

scientific article

Site-specific protein double labeling by expressed protein ligation: applications to repeat proteins

scientific article published on 9 November 2011

Stimuli-responsive smart gels realized via modular protein design

scientific article

Structure and function of KH domains

scientific article

Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins

scientific article

The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes

scientific article

The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold.

scientific article

The folding and design of repeat proteins: reaching a consensus

scientific article

The interface of protein structure, protein biophysics, and molecular evolution

scientific article

The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val.

scientific article

Understanding the physical basis for the side-chain conformational preferences of methionine.

scientific article

White and green screening with circular polymerase extension cloning for easy and reliable cloning

scientific article

List of works by Lynne Regan

A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics.

A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines

A designed repeat protein as an affinity capture reagent

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

A modular approach to the design of protein-based smart gels

A new bright green-emitting fluorescent protein--engineered monomeric and dimeric forms

A new method for the covalent attachment of DNA to a surface for single-molecule studies

A novel class of small molecule inhibitors of Hsp90.

A recurring theme in protein engineering: the design, stability and folding of repeat proteins.

A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics

A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals

All repeats are not equal: a module-based approach to guide repeat protein design

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction

Analysis of side chain mobility among protein G B1 domain mutants with widely varying stabilities

Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP.

Calorimetric study of a series of designed repeat proteins: modular structure and modular folding

Combinatorial approaches to protein stability and structure.

Consensus design as a tool for engineering repeat proteins.

Creating novel proteins by combining design and selection

Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand

Design of Stable α-Helical Arrays from an Idealized TPR Motif ⬇️

Designed phosphoprotein recognition in Escherichia coli

Designed proteins to modulate cellular networks

Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.

Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90: COMPUTATIONAL ANALYSIS AND PROTEIN ENGINEERING

Equilibrium transitions between side-chain conformations in leucine and isoleucine.

Fragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein

HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP.

Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP

Intensification: A Resource for Amplifying Population-Genetic Signals with Protein Repeats

Intrinsic α-helical and β-sheet conformational preferences: a computational case study of alanine.

Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome

LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions

Library approaches to biophysical problems.

Ligand binding by TPR domains

Ligand binding by repeat proteins: natural and designed

Local and long-range stability in tandemly arrayed tetratricopeptide repeats

Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchange

Molten globules move into action

Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro

Nanostructured functional films from engineered repeat proteins.

New insights into the interdependence between amino acid stereochemistry and protein structure

New materials from proteins and peptides

NextGen protein design

Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state.

Predicting the side-chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models.

Promoting convergence: The integrated graduate program in physical and engineering biology at Yale University, a new model for graduate education

Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins.

Protein design: Past, present, and future

Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area

Random close packing in protein cores. ⬇️

Reads meet rotamers: structural biology in the age of deep sequencing

Reassembled GFP: detecting protein-protein interactions and protein expression patterns

Redesign of a protein - peptide interaction: Characterization and applications

Revisiting the Ramachandran plot from a new angle

Routes to DNA accessibility: alternative pathways for nucleosome unwinding.

Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay

Sequence variation in ligand binding sites in proteins

Site-specific protein double labeling by expressed protein ligation: applications to repeat proteins

Stimuli-responsive smart gels realized via modular protein design

Structure and function of KH domains

Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins

The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes

The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold.

The folding and design of repeat proteins: reaching a consensus

The interface of protein structure, protein biophysics, and molecular evolution

The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val.

Understanding the physical basis for the side-chain conformational preferences of methionine.

White and green screening with circular polymerase extension cloning for easy and reliable cloning