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List of works by Burkhard Becher

ACTR-16. PERIPHERAL BLOOD CD4+ MONONUCLEAR CELL FRACTIONS ARE ASSOCIATED WITH OVERALL SURVIVAL AT FIRST RECURRENCE OF IDH-WILDTYPE GLIOBLASTOMA AFTER STANDARD CHEMORADIOTHERAPY: SECONDARY ANALYSES OF THE PHASE II DIRECTOR TRIAL

APC-derived cytokines and T cell polarization in autoimmune inflammation

scientific article

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer

scientific article published on 23 January 2019

ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation

scientific article published on 12 December 2017

Acquitting an APC: DCs found “not guilty” after trial by ablation ⬇️

scientific article published on 01 October 2012

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

scientific article published on 23 December 2007

Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing precursors in the cortico-medullary junction.

scientific article published on 8 June 2015

Anti-Human CD117 CAR T-Cells Efficiently Eliminate Hematopoietic Stem and CD117-Positive AML Cells ⬇️

scholarly article

Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells

scientific article published on 01 May 2020

Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain.

scientific article published on 14 June 2006

Anti–PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation

scientific article published on 12 June 2024

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS.

scientific article published on 19 August 2015

Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

scientific article published on 01 November 2018

Autoantibody-mediated demyelination depends on complement activation but not activatory Fc-receptors

scholarly article

B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution

scientific article published on 22 February 2010

B7 expression and antigen presentation by human brain endothelial cells: requirement for proinflammatory cytokines.

scientific article published on February 2000

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis

scientific article published on 18 July 2016

Brown adipose tissue monocytes support tissue expansion

scientific article published on 06 September 2021

Building a zoo of mice for genetic analyses: a comprehensive protocol for the rapid generation of BAC transgenic mice

scientific article published in April 2010

C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages

scientific article

CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system

scientific article published on 13 November 2010

CD39<sup>+</sup>PD-1<sup>+</sup>CD8<sup>+</sup> T cells mediate metastatic dormancy in breast cancer

scientific article published on 03 February 2021

CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS

scientific article published on 01 January 2000

CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo

scientific article published on 30 May 2019

CD95–CD95L: can the brain learn from the immune system? ⬇️

scientific article published on March 1, 1998

CNS live imaging reveals a new mechanism of myelination: the liquid croissant model

scientific article published in September 2011

CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis.

scientific article published on 17 May 2018

CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation

scientific article published on 13 May 2020

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

scientific article

Central nervous system immune surveillance: on natalizumab, dendritic cells, and dangerous immune privilege

scientific article published on 01 December 2008

Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss

scientific article

Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease

scientific article published on 29 October 2012

Conditional Gene-Targeting in Mice: Problems and Solutions

scientific article published on 01 May 2018

Contemplating autoimmunity in the Aegean islands

scientific article published in February 2016

Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation

scientific article published on 01 January 2019

Corrigendum: Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

scientific article published on 4 April 2017

Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells

scientific article published on June 2013

Cytokine networks in multiple sclerosis: lost in translation

scientific article published on June 2010

Cytokine networks in neuroinflammation

scientific article published on 5 December 2016

Deletion of Jun proteins in adult oligodendrocytes does not perturb cell survival, or myelin maintenance in vivo

scientific article (publication date: 2015)

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

scientific article published on 27 February 2005

Dendritic cells prevent rather than promote immunity conferred by a helicobacter vaccine using a mycobacterial adjuvant

scientific article published on 16 April 2011

Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens

scientific article

Dermal IL-17-producing γδ T cells establish long-lived memory in the skin

scientific article published on 2 September 2015

Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry

scientific article published on 03 June 2019

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.

scientific article

Disease control in cutaneous leishmaniasis is independent of IL-22

scientific article published on 07 July 2014

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

scientific article published on 09 May 2021

Does dietary salt induce autoimmunity?

scientific article published on 7 May 2013

Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System

scientific article published in February 2017

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development

scientific article published on 01 April 2020

Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo.

scientific article published on 12 January 2014

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

scientific article

Epithelial proliferation in inflammatory skin disease is regulated by tetratricopeptide repeat domain 7 (Ttc7) in fibroblasts and lymphocytes

scientific article published on 14 June 2018

Erratum: Sall1 is a transcriptional regulator defining microglia identity and function.

scientific article

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

scientific article published on 01 April 2018

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos

scientific article

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

scientific article

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

scientific article published on 23 January 2005

Experimental immunology in Zürich: the legacy of studying disease-related Ag

scientific article published on 01 November 2008

Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy

scientific article published on 01 January 2020

Fas expression on human fetal astrocytes without susceptibility to fas-mediated cytotoxicity

scientific article published in May 1998

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

scientific article published on 09 May 2019

GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis

scientific article published on 22 July 2019

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage.

scientific article published on October 2015

GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

scientific article published on 23 June 2020

GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation

scientific article published on November 2016

GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation

scientific article published in 2021

Germinal center B cells are dispensable in prion transport and neuroinvasion

scientific article published on 26 October 2007

Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System

scientific article published on 01 January 2020

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells

scientific article published on 01 November 2018

Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain

scientific article published on 04 February 2020

Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues

scientific article published on 01 November 2020

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

Gut-licensed IFNγ NK cells drive LAMP1TRAIL anti-inflammatory astrocytes

scientific article

Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells

scientific article

Helicobacter pylori-specific protection against inflammatory bowel disease requires the NLRP3 inflammasome and IL-18.

scientific article published on April 2015

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

scientific article published on 18 February 2020

Hiding under the skin: Interleukin-17-producing γδ T cells go under the skin?

scientific article published on 01 December 2012

High Dimensional Cytometry of Central Nervous System Leukocytes During Neuroinflammation

scientific article published on January 2017

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

scientific article published on 6 February 2018

High-dimensional analysis of the murine myeloid cell system.

scientific article published on 12 October 2014

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

scientific article published on 8 January 2018

High-dimensional single-cell analysis reveals the immune signature of narcolepsy.

scientific article

Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins

scientific article

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

scientific article

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

scholarly article

IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46.

scientific article published on 10 October 2010

IL-12 protects from psoriasiform skin inflammation

scientific article

IL-12 superfamily members guiding the function of Rorγt-dependent innate lymphocytes

IL-12-and IL-23 in health and disease

scientific article

IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice

scientific article published on 15 December 2008

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells

scientific article published on 13 August 2012

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

scientific article published on 01 December 2007

IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease

scientific article

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis.

scientific article

IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival

scientific article published on 30 December 2019

IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo

scientific article published on 01 July 2009

IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity

scientific article

IL-23: one cytokine in control of autoimmunity

scientific article published on September 2012

IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression.

scientific article published on 29 November 2017

IL-9 as a mediator of Th17-driven inflammatory disease

scientific article published on 13 July 2009

IL17A-Mediated Endothelial Breach Promotes Metastasis Formation

scientific article published on 19 November 2015

Immune attack: the role of inflammation in Alzheimer disease.

scientific article published on June 2015

Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity

scientific article published on 16 September 2019

Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis

scientific article published in September 1997

Immunotherapy for multiple sclerosis: from theory to practice

scientific article published on 01 October 1996

Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis

scientific article published on 22 November 2018

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

scientific article published on 25 November 2012

Innate and adaptive immune responses in the CNS.

scientific article published on September 2015

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

scientific article

Innate lymphoid cells as regulators of the tumor microenvironment

scientific article published on 01 February 2019

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

scientific article

Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation

scientific article published on 13 August 2006

Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

scientific article published on 16 December 2016

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection

scientific article

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

scientific article published on 19 January 2021

Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.

scientific article published on 10 June 2013

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.

scientific article published in July 2017

MAFG-driven astrocytes promote CNS inflammation

scientific article published on 12 February 2020

Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage.

scientific article

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

scientific article published on 01 March 2020

Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy

scientific article published on 21 November 2019

Modeling multiple sclerosis in laboratory animals.

scientific article published on 03 October 2009

Monocytes promote UV-induced epidermal carcinogenesis

publication published on 02 April 2021

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

scientific article published on 3 October 2014

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

scientific article published on 24 March 2021

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses

scientific article

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

scientific article published on 4 April 2016

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

scientific article published on November 2016

Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity

scientific article

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

scientific article

Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss

scientific article published on 02 September 2013

Neutralization of colony-stimulating factor 1 receptor prevents sickness behavior syndrome by reprogramming inflammatory monocytes to produce IL-10.

scientific article published on 4 March 2015

New insights into IL-12-mediated tumor suppression.

scientific article

Non-neutralizing antibodies protect against chronic LCMV infection by promoting infection of inflammatory monocytes in mice

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

scientific article published on 03 April 2020

PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis

scientific article published on 10 December 2014

Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis.

scientific article

Pericytes regulate vascular immune homeostasis in the CNS

scientific article

Perspectives on cytokine-directed therapies in multiple sclerosis

scientific article

Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model

scientific article published on 01 April 2020

Primary oligodendrocyte death does not elicit anti-CNS immunity

scientific article published on 26 February 2012

Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.

scientific article published on 11 June 2015

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

scientific article published on 18 August 2020

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

scientific article published in 2024

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

scientific article

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

scientific article

Rational Combination of Immunotherapies with Clinical Efficacy in Mice with Advanced Cancer

scientific article published on 3 July 2015

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

scientific article published on 01 December 2018

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

scientific article published in November 2004

Restoration of Natural Killer Cell Antimetastatic Activity by IL12 and Checkpoint Blockade

scientific article published on 17 October 2017

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

scientific article

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

scientific article

Sall1 is a transcriptional regulator defining microglia identity and function.

scientific article published on 24 October 2016

SerpinB1 controls encephalitogenic T helper cells in neuroinflammation

scientific article published on 23 September 2019

Single cell mapping of human brain tumors reveals tumor-specific education of tissue-invading leukocytes.

scientific article published in 2020

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

scientific article published on 22 May 2020

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

scientific article published on 28 March 2021

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

scientific article published on 21 January 2020

Skipping adolescence to become super-inflammatory monocytes

scientific article published on 20 April 2020

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

scientific article published on 12 February 2018

Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia

scientific article

T cell contamination in flow cytometry gating approaches for analysis of innate lymphoid cells.

scientific article

T cell-specific inactivation of mouse CD2 by CRISPR/Cas9.

scientific article published on 23 February 2016

T cells in patients with narcolepsy target self-antigens of hypocretin neurons

scientific article published in Nature

T-bet or not T-bet: taking the last bow on the autoimmunity stage.

scientific article

T-helper cells: methods and protocols. Preface

scientific article published on 01 January 2014

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function

scientific article

TH17 cytokines in autoimmune neuro-inflammation ⬇️

scientific article published on 09 September 2011

Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8+ T Cells

scientific article published on 19 February 2019

Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective

scientific article published on 01 January 2020

Th17 cells in autoimmune disease: changing the verdict.

scientific article published on March 2009

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development

scientific article published on 01 June 2020

The CNS Immune Landscape from the Viewpoint of a T Cell

scientific article published on 29 August 2019

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.

scientific article

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

scientific article published on 6 November 2017

The Fas pathway is involved in pancreatic beta cell secretory function

scholarly article

The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type I T cell responses

scientific article published on 01 December 2020

The Good, the Bad, or the Pretty: IL-17 Builds Lymphoid Tissues in the Brain

scientific article published in December 2015

The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells.

scientific article published on 5 December 2015

The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.

scientific article

The end of gating? An introduction to automated analysis of high dimensional cytometry data.

scientific article

The end of omics? High dimensional single cell analysis in precision medicine

scientific article published on 25 January 2019

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes

scientific article published on 4 October 2017

Therapeutic antibodies in multiple sclerosis

scientific article published on 01 January 2008

Thy1+ Sca1+ innate lymphoid cells infiltrate the CNS during autoimmune inflammation, but do not contribute to disease development

scientific article

Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs

scientific article

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

scientific article published on 29 June 2020

Twin study reveals non-heritable immune perturbations in multiple sclerosis

scientific article published on 16 February 2022

[CORRECTION] High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

scientific article published in March 2018

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