List of works - Luciano G. Martelotto

A crucial requirement for Hedgehog signaling in small cell lung cancer

scientific article

Breast cancer intra-tumor heterogeneity

scientific article

Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

scientific article

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

scientific article

Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations

scientific article published on 28 October 2014

Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

scientific article published on 22 May 2015

Genomic landscape of adenoid cystic carcinoma of the breast

scientific article

An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer.

scientific article

The Genomic Landscape of Male Breast Cancers

scientific article published on 9 March 2016

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression

scientific article published on 17 November 2015

Gene expression analysis at the onset of aposporous apomixis in Paspalum notatum.

scientific article published on 15 May 2008

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury

scientific article published on 23 August 2013

Mechanisms of Hedgehog signalling in cancer

scientific article published on August 30, 2011

Uterine adenosarcomas are mesenchymal neoplasms.

scientific article published on 23 November 2015

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer

scientific article

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

scientific article published on 6 February 2017

MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast

scientific article published in November 2015

The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis-generating study

scientific article published on 23 May 2015

Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer

scientific article published on 05 August 2016

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

scientific article published on 20 October 2016

Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast

scientific article published on 26 June 2014

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

scientific article

TP53 Mutational Spectrum in Endometrioid and Serous Endometrial Cancers

scientific article

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

scientific article published on 8 May 2018

Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer.

scientific article published on 15 March 2017

Characterization of a novel inhibitory feedback of the anti-anti-sigma SpoIIAA on Spo0A activation during development in Bacillus subtilis.

scientific article published in March 2003

Next-generation sequence analysis of cancer xenograft models.

scientific article

MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene

scientific article published on 17 November 2017

Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing.

scientific article

Expressed sequence tag analysis and development of gene associated markers in a near-isogenic plant system of Eragrostis curvula.

scientific article

Genome polymorphisms and gene differential expression in a 'back-and-forth' ploidy-altered series of weeping lovegrass (Eragrostis curvula).

scientific article published on 17 August 2006

Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast

scientific article published in December 2017

Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair

scientific article published on 11 February 2017

Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland

scientific article published on October 2015

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

scientific article published on 01 July 2018

Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids

scientific article published on June 27, 2013

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease

scientific article

Visualizing renal primary cilia.

scientific article published on March 2013

Purification and biological characterization of N-acetyl beta-D glucosaminidase from Bufo arenarum spermatozoa

scientific article published on 01 October 2000

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

scientific article published on 19 February 2021

Antigen-driven EGR2 expression is required for exhausted CD8<sup>+</sup> T cell stability and maintenance

scientific article published on 13 May 2021

Single-Cell Applications of Next-Generation Sequencing

scientific article published on 01 October 2019

List of works by Luciano G. Martelotto

A crucial requirement for Hedgehog signaling in small cell lung cancer

Breast cancer intra-tumor heterogeneity

Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations

Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

Genomic landscape of adenoid cystic carcinoma of the breast

An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer.

The Genomic Landscape of Male Breast Cancers

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression

Gene expression analysis at the onset of aposporous apomixis in Paspalum notatum.

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury

Mechanisms of Hedgehog signalling in cancer

Uterine adenosarcomas are mesenchymal neoplasms.

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast

The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis-generating study

Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

TP53 Mutational Spectrum in Endometrioid and Serous Endometrial Cancers

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer.

Characterization of a novel inhibitory feedback of the anti-anti-sigma SpoIIAA on Spo0A activation during development in Bacillus subtilis.

Next-generation sequence analysis of cancer xenograft models.

MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene

Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing.

Expressed sequence tag analysis and development of gene associated markers in a near-isogenic plant system of Eragrostis curvula.

Genome polymorphisms and gene differential expression in a 'back-and-forth' ploidy-altered series of weeping lovegrass (Eragrostis curvula).

Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast

Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair

Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease

Visualizing renal primary cilia.

Purification and biological characterization of N-acetyl beta-D glucosaminidase from Bufo arenarum spermatozoa

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

Antigen-driven EGR2 expression is required for exhausted CD8<sup>+</sup> T cell stability and maintenance

Single-Cell Applications of Next-Generation Sequencing

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles