List of works - Taku Nagai

17beta-estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats

scientific article published on 22 February 2007

A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.

scientific article published on 7 November 2006

A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference.

scientific article

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk

scientific article published on 22 July 2020

Acid load during total parenteral nutrition: comparison of hydrochloric acid and acetic acid on plasma acid-base balance

scientific article published on 01 April 2000

Activation of post-synaptic dopamine D₁ receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling

scientific article published on 01 December 2007

Alteration of gene expression and DNA methylation in drug-resistant gastric cancer.

scientific article

Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene

scientific article published on 26 June 2014

Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules.

scientific article

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

scientific article

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

scientific article

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes

scientific article published on 30 January 2018

Author Correction: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

scientific article published on 03 May 2019

Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1.

scientific article published on December 2008

Behavioral abnormality and pharmacologic response in social isolation-reared mice.

scientific article published on 31 March 2009

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

scientific article published on 8 September 2011

Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit

scientific journal article

Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.

scientific article published on 27 July 2011

CD38 is critical for social behaviour by regulating oxytocin secretion

scientific article published on 7 February 2007

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

scientific journal article

Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor.

scientific article published on 17 December 2013

Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine

scientific article published on 7 March 2007

Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.

scientific article

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.

scientific article published on 15 November 2002

Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice.

scientific article

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

scientific article published on 05 February 2020

Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.

scientific article published on 18 December 2014

Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence

scientific article published on 18 November 2013

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

scientific article published on 2 March 2007

Drug dependence, synaptic plasticity, and tissue plasminogen activator.

scientific article

Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment

scientific article published on 3 August 2011

Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial-cell-line-derived neurotrophic factor mutant mice.

scientific article published on 13 March 2007

Enhancement of immobility induced by repeated phencyclidine injection: association with c-Fos protein in the mouse brain.

scientific article published in September 2001

Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice

scientific article published on 23 March 2017

Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice

scientific article published on 18 November 2011

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

scientific article published on 13 May 2015

GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.

scientific article published on 12 November 2008

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

scientific article published in Scientific Reports

Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats.

scientific article published on 9 August 2007

Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.

scientific article published in November 2014

Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory

scientific article

Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes.

scientific article published on 10 September 2014

Insular neural system controls decision-making in healthy and methamphetamine-treated rats

scientific article

Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

scientific article published in September 2006

Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice

scientific article published on 14 August 2006

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.

scientific article

Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.

scientific article published on March 2014

Methylation analysis for postpartum depression: a case control study.

scientific article published on 20 June 2019

Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: the role of Girdin in the CNS.

scientific article published on March 2016

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood.

scientific article published on 10 April 2009

Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice

scientific article published on 6 October 2006

Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a.

scientific article published on 9 December 2017

Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I.

scientific article published on 21 November 2012

Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors

scientific article published in September 2000

Nicotine ameliorates impairment of working memory in methamphetamine-treated rats

scientific article

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.

scientific article published on 25 May 2013

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

scientific article

Noradrenergic refinement of glutamatergic neuronal circuits in the lateral superior olivary nucleus before hearing onset.

scientific article

Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons

scientific article published on 31 July 2014

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

scientific article published on 19 January 2016

Phosphorylation Signals in Striatal Medium Spiny Neurons.

scientific article

Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice

scientific article published on 6 September 2012

Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants.

scientific article published on 10 March 2014

Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system

scientific article published on 5 February 2007

Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex

scientific article

Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex

scientific article

Prostaglandin E receptor EP1 controls impulsive behavior under stress.

scientific article

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

scientific article published on 22 April 2019

Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits

scientific article published on 6 January 2015

Reinforcing effects of morphine are reduced in tissue plasminogen activator-knockout mice

scientific article published on 20 February 2007

Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice.

scientific article

Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol

scientific article

Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens.

scientific article published on 25 November 2007

Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.

scientific article published in March 2004

SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization

scientific article published on 16 September 2013

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus

scientific article published on 10 April 2020

Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice.

scientific article published on 28 July 2009

Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.

scientific article published on 24 October 2009

Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice

scientific article

Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene

scientific article published on 28 July 2015

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model

scientific article published on 07 March 2007

The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients

scientific article published on 27 March 2010

The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.

scientific article published on 11 July 2008

The long-lasting effects of cross-fostering on the emotional behavior in ICR mice.

scientific article published on 6 November 2008

The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1

scientific journal article

The role of tissue plasminogen activator in methamphetamine-related reward and sensitization.

scientific article published in February 2005

Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter

scientific article published on 25 October 2012

List of works by Taku Nagai

17beta-estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats

A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.

A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference.

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk

Acid load during total parenteral nutrition: comparison of hydrochloric acid and acetic acid on plasma acid-base balance

Activation of post-synaptic dopamine D₁ receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling

Alteration of gene expression and DNA methylation in drug-resistant gastric cancer.

Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene

Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules.

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes

Author Correction: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1.

Behavioral abnormality and pharmacologic response in social isolation-reared mice.

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit

Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.

CD38 is critical for social behaviour by regulating oxytocin secretion

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor.

Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine

Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.

Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice.

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.

Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Drug dependence, synaptic plasticity, and tissue plasminogen activator.

Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment

Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial-cell-line-derived neurotrophic factor mutant mice.

Enhancement of immobility induced by repeated phencyclidine injection: association with c-Fos protein in the mouse brain.

Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice

Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats.

Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.

Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory

Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes.

Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.

Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.

Methylation analysis for postpartum depression: a case control study.

Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: the role of Girdin in the CNS.

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood.

Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice

Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a.

Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I.

Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors

Nicotine ameliorates impairment of working memory in methamphetamine-treated rats

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

Noradrenergic refinement of glutamatergic neuronal circuits in the lateral superior olivary nucleus before hearing onset.

Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

Phosphorylation Signals in Striatal Medium Spiny Neurons.

Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice

Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants.

Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system

Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex

Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex

Prostaglandin E receptor EP1 controls impulsive behavior under stress.

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits

Reinforcing effects of morphine are reduced in tissue plasminogen activator-knockout mice

Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice.

Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol

Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens.

Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.

SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus

Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice.

Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.

Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice